(12 nodes) One carbon pool by folate network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SHMT2	Serine hydroxymethyltransferase 2. (528 aa)
	shmt2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (501 aa)
	mthfd2	Uncharacterized protein. (338 aa)
	gart	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1007 aa)
	LOC101155190	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (175 aa)
	mthfd1l	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (966 aa)
	LOC101174548	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (881 aa)
	mthfr	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (657 aa)
	mtr	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1270 aa)
	gldc	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1031 aa)
	amt	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (414 aa)
	LOC101165643	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (348 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101155190	LOC101165643	ENSORLP00000011711	ENSORLP00000045156	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.799
LOC101155190	LOC101174548	ENSORLP00000011711	ENSORLP00000021416	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b.	0.437
LOC101155190	SHMT2	ENSORLP00000011711	ENSORLP00000004789	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Serine hydroxymethyltransferase 2.	0.979
LOC101155190	amt	ENSORLP00000011711	ENSORLP00000030030	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.998
LOC101155190	gart	ENSORLP00000011711	ENSORLP00000007887	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.875
LOC101155190	gldc	ENSORLP00000011711	ENSORLP00000029139	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.999
LOC101155190	mthfd1l	ENSORLP00000011711	ENSORLP00000018107	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.437
LOC101155190	mthfd2	ENSORLP00000011711	ENSORLP00000007827	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Uncharacterized protein.	0.799
LOC101155190	mthfr	ENSORLP00000011711	ENSORLP00000023652	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.931
LOC101155190	mtr	ENSORLP00000011711	ENSORLP00000026510	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.567
LOC101155190	shmt2	ENSORLP00000011711	ENSORLP00000006970	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.979
LOC101165643	LOC101155190	ENSORLP00000045156	ENSORLP00000011711	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.799
LOC101165643	LOC101174548	ENSORLP00000045156	ENSORLP00000021416	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b.	0.968
LOC101165643	SHMT2	ENSORLP00000045156	ENSORLP00000004789	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	Serine hydroxymethyltransferase 2.	0.983
LOC101165643	amt	ENSORLP00000045156	ENSORLP00000030030	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.988
LOC101165643	gart	ENSORLP00000045156	ENSORLP00000007887	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.999
LOC101165643	gldc	ENSORLP00000045156	ENSORLP00000029139	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.962
LOC101165643	mthfd1l	ENSORLP00000045156	ENSORLP00000018107	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.968
LOC101165643	mthfd2	ENSORLP00000045156	ENSORLP00000007827	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	Uncharacterized protein.	0.901
LOC101165643	mthfr	ENSORLP00000045156	ENSORLP00000023652	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.992