(16 nodes) Resolution of meiotic recombination intermediates network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ercc4	Excision repair cross-complementation group 4. (889 aa)
	ankle1	Uncharacterized protein. (1140 aa)
	slx4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1590 aa)
	cenpx	Uncharacterized protein. (107 aa)
	top2b	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1599 aa)
	Hfm1	Helicase for meiosis 1. (785 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (656 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (720 aa)
	shoc1	Uncharacterized protein. (1417 aa)
	EME2	ERCC4 domain-containing protein. (443 aa)
	eme1	Essential meiotic structure-specific endonuclease 1. (459 aa)
	fancm	Uncharacterized protein. (1993 aa)
	rmi1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (648 aa)
	top2a	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1571 aa)
	meiob	Methionine sulfoxide reductase B1b. (462 aa)
	tex11	Testis expressed 11. (910 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EME2	eme1	ENSORLP00000028406	ENSORLP00000018481	ERCC4 domain-containing protein.	Essential meiotic structure-specific endonuclease 1.	0.844
EME2	ercc4	ENSORLP00000028406	ENSORLP00000003684	ERCC4 domain-containing protein.	Excision repair cross-complementation group 4.	0.684
EME2	fancm	ENSORLP00000028406	ENSORLP00000018174	ERCC4 domain-containing protein.	Uncharacterized protein.	0.674
EME2	mus81	ENSORLP00000028406	ENSORLP00000036282	ERCC4 domain-containing protein.	MUS81 structure-specific endonuclease subunit.	0.990
EME2	rmi1	ENSORLP00000028406	ENSORLP00000006523	ERCC4 domain-containing protein.	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae).	0.477
EME2	slx4	ENSORLP00000028406	ENSORLP00000041774	ERCC4 domain-containing protein.	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae).	0.572
Hfm1	fancm	ENSORLP00000036743	ENSORLP00000018174	Helicase for meiosis 1.	Uncharacterized protein.	0.578
Hfm1	meiob	ENSORLP00000036743	ENSORLP00000003887	Helicase for meiosis 1.	Methionine sulfoxide reductase B1b.	0.558
Hfm1	mlh1	ENSORLP00000036743	ENSORLP00000034579	Helicase for meiosis 1.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.730
Hfm1	mus81	ENSORLP00000036743	ENSORLP00000036282	Helicase for meiosis 1.	MUS81 structure-specific endonuclease subunit.	0.640
Hfm1	shoc1	ENSORLP00000036743	ENSORLP00000033921	Helicase for meiosis 1.	Uncharacterized protein.	0.454
Hfm1	tex11	ENSORLP00000036743	ENSORLP00000002407	Helicase for meiosis 1.	Testis expressed 11.	0.552
Hfm1	top2a	ENSORLP00000036743	ENSORLP00000005530	Helicase for meiosis 1.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.407
Hfm1	top2b	ENSORLP00000036743	ENSORLP00000036855	Helicase for meiosis 1.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.407
cenpx	eme1	ENSORLP00000037961	ENSORLP00000018481	Uncharacterized protein.	Essential meiotic structure-specific endonuclease 1.	0.453
cenpx	ercc4	ENSORLP00000037961	ENSORLP00000003684	Uncharacterized protein.	Excision repair cross-complementation group 4.	0.560
cenpx	fancm	ENSORLP00000037961	ENSORLP00000018174	Uncharacterized protein.	Uncharacterized protein.	0.996
cenpx	mus81	ENSORLP00000037961	ENSORLP00000036282	Uncharacterized protein.	MUS81 structure-specific endonuclease subunit.	0.549
cenpx	rmi1	ENSORLP00000037961	ENSORLP00000006523	Uncharacterized protein.	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae).	0.910
cenpx	slx4	ENSORLP00000037961	ENSORLP00000041774	Uncharacterized protein.	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae).	0.546