(16 nodes) Telomere maintenance via recombination network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (627 aa)
	ercc4	Excision repair cross-complementation group 4. (889 aa)
	smc5	Structural maintenance of chromosomes 5. (1072 aa)
	LOC101163867	Si:dkey-119f1.1. (1129 aa)
	rad51d	RAD51 paralog D. (332 aa)
	ercc1	Excision repair cross-complementation group 1. (341 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (396 aa)
	H2MVD7_ORYLA	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (308 aa)
	LOC111946820	Structural maintenance of chromosomes 6. (1041 aa)
	Rad51c	RAD51 paralog C. (307 aa)
	tprkb	Tp53rk binding protein; Belongs to the CGI121/TPRKB family. (174 aa)
	nsmce2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (230 aa)
	Tep1	Uncharacterized protein. (83 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1311 aa)
	ENSORLP00000040907	TROVE domain-containing protein. (289 aa)
	brca2	BRCA2 DNA repair associated. (3161 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000040907	Tep1	ENSORLP00000040907	ENSORLP00000030111	TROVE domain-containing protein.	Uncharacterized protein.	0.741
H2MVD7_ORYLA	Rad51c	ENSORLP00000022767	ENSORLP00000024828	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	RAD51 paralog C.	0.998
H2MVD7_ORYLA	brca2	ENSORLP00000022767	ENSORLP00000039367	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	BRCA2 DNA repair associated.	0.954
H2MVD7_ORYLA	ercc1	ENSORLP00000022767	ENSORLP00000020313	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	Excision repair cross-complementation group 1.	0.730
H2MVD7_ORYLA	ercc4	ENSORLP00000022767	ENSORLP00000003684	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	Excision repair cross-complementation group 4.	0.781
H2MVD7_ORYLA	nsmce2	ENSORLP00000022767	ENSORLP00000028087	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	0.489
H2MVD7_ORYLA	rad50	ENSORLP00000022767	ENSORLP00000037867	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	RAD50 homolog, double strand break repair protein.	0.854
H2MVD7_ORYLA	rad51	ENSORLP00000022767	ENSORLP00000022299	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.983
H2MVD7_ORYLA	rad51d	ENSORLP00000022767	ENSORLP00000019089	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	RAD51 paralog D.	0.987
H2MVD7_ORYLA	smc5	ENSORLP00000022767	ENSORLP00000008253	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	Structural maintenance of chromosomes 5.	0.613
H2MVD7_ORYLA	xrcc1	ENSORLP00000022767	ENSORLP00000039866	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.664
LOC101163867	LOC111946820	ENSORLP00000017434	ENSORLP00000023062	Si:dkey-119f1.1.	Structural maintenance of chromosomes 6.	0.559
LOC101163867	nsmce2	ENSORLP00000017434	ENSORLP00000028087	Si:dkey-119f1.1.	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	0.985
LOC101163867	rad50	ENSORLP00000017434	ENSORLP00000037867	Si:dkey-119f1.1.	RAD50 homolog, double strand break repair protein.	0.434
LOC101163867	rad51	ENSORLP00000017434	ENSORLP00000022299	Si:dkey-119f1.1.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.725
LOC101163867	rad51d	ENSORLP00000017434	ENSORLP00000019089	Si:dkey-119f1.1.	RAD51 paralog D.	0.592
LOC101163867	smc5	ENSORLP00000017434	ENSORLP00000008253	Si:dkey-119f1.1.	Structural maintenance of chromosomes 5.	0.989
LOC111946820	LOC101163867	ENSORLP00000023062	ENSORLP00000017434	Structural maintenance of chromosomes 6.	Si:dkey-119f1.1.	0.559
LOC111946820	nsmce2	ENSORLP00000023062	ENSORLP00000028087	Structural maintenance of chromosomes 6.	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	0.985
LOC111946820	rad50	ENSORLP00000023062	ENSORLP00000037867	Structural maintenance of chromosomes 6.	RAD50 homolog, double strand break repair protein.	0.434