(42 nodes) Morphogenesis of an epithelial sheet network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	arhgap24	Rho GTPase activating protein 24. (824 aa)
	LOC101165469	Phosphatase and actin regulator. (622 aa)
	LOC101165277	ADAM metallopeptidase domain 17b. (844 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	LOC101167618	Uncharacterized protein. (193 aa)
	phactr4	Phosphatase and actin regulator. (836 aa)
	LOC101166746	Phosphatase and actin regulator. (584 aa)
	LOC101171872	ADAM metallopeptidase domain 17a. (850 aa)
	LOC101165732	Peptidase S72 domain-containing protein. (901 aa)
	ajuba	Ajuba. (694 aa)
	vax2	Ventral anterior homeobox 2. (306 aa)
	LOC101161908	T-box transcription factor 5a. (525 aa)
	LOC101160539	Uncharacterized protein. (218 aa)
	flrt3	Fibronectin leucine rich transmembrane 3. (650 aa)
	LOC105358811	MADS-box domain-containing protein. (552 aa)
	bves	Blood vessel epicardial substance. (356 aa)
	LOC101158607	Uncharacterized protein. (193 aa)
	LOC101159348	Link domain-containing protein. (402 aa)
	LOC101163415	Myocardin related transcription factor Aa. (1117 aa)
	slc39a6	Solute carrier family 39 member 6. (709 aa)
	MPP5	Membrane palmitoylated protein 5; Belongs to the MAGUK family. (667 aa)
	pitx2	Homeobox protein. (366 aa)
	LOC101173444	Uncharacterized protein. (193 aa)
	LOC105355710	Si:ch211-247j9.1. (672 aa)
	prmt7	Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (685 aa)
	srf	Serum response factor b. (611 aa)
	LOC101157704	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (765 aa)
	H2MBJ4_ORYLA	Uncharacterized protein. (306 aa)
	RHOB	Ras homolog family member B. (191 aa)
	LOC101158357	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (514 aa)
	mpp5	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (646 aa)
	dag1	Dystroglycan 1. (868 aa)
	ccn1	Cellular communication network factor 1. (376 aa)
	LOC100049520	POU domain protein. (469 aa)
	LOC101174784	Uncharacterized protein. (822 aa)
	LOC101162937	Phosphatase and actin regulator 4a. (1122 aa)
	LOC101155194	Uncharacterized protein. (193 aa)
	mab21l2	Mab-21-like 2. (359 aa)
	LOC100049251	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (514 aa)
	mab21l1	Mab-21-like 1. (359 aa)
	vax1	Ventral anterior homeobox 1. (323 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100049251	LOC101158357	ENSORLP00000008829	ENSORLP00000015542	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.	0.901
LOC100049520	LOC101159348	ENSORLP00000013122	ENSORLP00000029068	POU domain protein.	Link domain-containing protein.	0.559
LOC101158357	LOC100049251	ENSORLP00000015542	ENSORLP00000008829	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.	0.901
LOC101159348	LOC100049520	ENSORLP00000029068	ENSORLP00000013122	Link domain-containing protein.	POU domain protein.	0.559
LOC101159348	fgf8	ENSORLP00000029068	ENSORLP00000042553	Link domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.565
LOC101161908	pitx2	ENSORLP00000034931	ENSORLP00000025501	T-box transcription factor 5a.	Homeobox protein.	0.431
LOC101161908	vax2	ENSORLP00000034931	ENSORLP00000036208	T-box transcription factor 5a.	Ventral anterior homeobox 2.	0.514
LOC101163415	LOC105358811	ENSORLP00000027839	ENSORLP00000031967	Myocardin related transcription factor Aa.	MADS-box domain-containing protein.	0.908
LOC101163415	srf	ENSORLP00000027839	ENSORLP00000016334	Myocardin related transcription factor Aa.	Serum response factor b.	0.908
LOC101165277	LOC101171872	ENSORLP00000043138	ENSORLP00000039739	ADAM metallopeptidase domain 17b.	ADAM metallopeptidase domain 17a.	0.902
LOC101165732	dag1	ENSORLP00000037673	ENSORLP00000013717	Peptidase S72 domain-containing protein.	Dystroglycan 1.	0.902
LOC101171872	LOC101165277	ENSORLP00000039739	ENSORLP00000043138	ADAM metallopeptidase domain 17a.	ADAM metallopeptidase domain 17b.	0.902
LOC105358811	LOC101163415	ENSORLP00000031967	ENSORLP00000027839	MADS-box domain-containing protein.	Myocardin related transcription factor Aa.	0.908
LOC105358811	pitx2	ENSORLP00000031967	ENSORLP00000025501	MADS-box domain-containing protein.	Homeobox protein.	0.677
LOC105358811	srf	ENSORLP00000031967	ENSORLP00000016334	MADS-box domain-containing protein.	Serum response factor b.	0.905
MPP5	mpp5	ENSORLP00000026030	ENSORLP00000014773	Membrane palmitoylated protein 5; Belongs to the MAGUK family.	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family.	0.901
dag1	LOC101165732	ENSORLP00000013717	ENSORLP00000037673	Dystroglycan 1.	Peptidase S72 domain-containing protein.	0.902
fgf8	LOC101159348	ENSORLP00000042553	ENSORLP00000029068	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Link domain-containing protein.	0.565
fgf8	flrt3	ENSORLP00000042553	ENSORLP00000034138	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibronectin leucine rich transmembrane 3.	0.727
fgf8	pitx2	ENSORLP00000042553	ENSORLP00000025501	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein.	0.467