(59 nodes) Protease binding network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	brca2	BRCA2 DNA repair associated. (3161 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (858 aa)
	LOC101168653	RING-CH-type domain-containing protein. (922 aa)
	LOC101161410	Surfactant protein Bb. (358 aa)
	LOC105356386	DBB domain-containing protein. (589 aa)
	trip4	Thyroid hormone receptor interactor 4. (638 aa)
	cltc	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1695 aa)
	BDKRB2	Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
	itga3	Integrin, alpha 3b; Belongs to the integrin alpha chain family. (1075 aa)
	LOC101169003	Protein YIPF. (252 aa)
	LOC101158686	MALT paracaspase 2. (843 aa)
	LOC101158194	MALT paracaspase 3. (557 aa)
	derl1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (253 aa)
	timp4	TIMP metallopeptidase inhibitor 4, tandem duplicate 2. (224 aa)
	BFAR	Bifunctional apoptosis regulator. (457 aa)
	fadd	Uncharacterized protein. (192 aa)
	rnf139	Ring finger protein 139. (703 aa)
	nfrkb	Nuclear factor related to kappaB binding protein. (1274 aa)
	LOC101171170	MALT paracaspase 1. (811 aa)
	LOC101173230	Uncharacterized protein. (340 aa)
	prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (466 aa)
	tysnd1	Trypsin domain containing 1. (526 aa)
	LOC101155616	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (424 aa)
	MARCHF6	Membrane associated ring-CH-type finger 6. (898 aa)
	timp-2b	Tissue inhibitor of metalloproteinase-2b. (220 aa)
	LOC101164095	Uncharacterized protein. (286 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (590 aa)
	timp3	NTR domain-containing protein. (212 aa)
	LOC101164440	Cystatin domain-containing protein. (98 aa)
	LOC101172843	Uncharacterized protein. (543 aa)
	LOC101172593	Tumor necrosis factor a (TNF superfamily, member 2). (279 aa)
	serpine1	SERPIN domain-containing protein; Belongs to the serpin family. (447 aa)
	timp2	Tissue inhibitor of metalloproteinase-2a. (221 aa)
	flot2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (432 aa)
	psap	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (532 aa)
	fbxo45	F-box protein 45. (288 aa)
	twnk	Twinkle mtDNA helicase. (724 aa)
	polg	Polymerase (DNA directed), gamma. (1202 aa)
	amfr	Autocrine motility factor receptor b. (635 aa)
	LOC101168028	BCL2 like 10. (192 aa)
	LOC101157726	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (465 aa)
	LOC101157554	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1677 aa)
	stil	SERPIN domain-containing protein; Belongs to the serpin family. (1406 aa)
	H2MJP6_ORYLA	Uncharacterized protein. (428 aa)
	chmp3	Charged multivesicular body protein 3. (220 aa)
	pink1	PTEN induced kinase 1. (577 aa)
	cflar	FLICE-like inhibitory protein; Belongs to the peptidase C14A family. (460 aa)
	bcl2	BCL2 apoptosis regulator b. (202 aa)
	casp8ap2	Uncharacterized protein. (1602 aa)
	LOC101173752	IGv domain-containing protein. (224 aa)
	serpinf2	SERPIN domain-containing protein; Belongs to the serpin family. (476 aa)
	f3	Coagulation factor IIIa. (284 aa)
	riok3	Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (506 aa)
	cltcl1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1658 aa)
	LOC101164618	CASP2 and RIPK1 domain containing adaptor with death domain. (203 aa)
	fn1	Fibronectin-1. (2503 aa)
	LOC101164911	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
	yipf5	Protein YIPF. (254 aa)
	H2L3P1_ORYLA	Extracellular matrix protein 1a. (122 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BFAR	LOC101164618	ENSORLP00000043268	ENSORLP00000023990	Bifunctional apoptosis regulator.	CASP2 and RIPK1 domain containing adaptor with death domain.	0.489
H2L3P1_ORYLA	timp3	ENSORLP00000000367	ENSORLP00000011559	Extracellular matrix protein 1a.	NTR domain-containing protein.	0.402
LOC101155616	LOC101157726	ENSORLP00000008720	ENSORLP00000016266	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.544
LOC101155616	LOC101164911	ENSORLP00000008720	ENSORLP00000002427	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.590
LOC101155616	flot2	ENSORLP00000008720	ENSORLP00000014302	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.586
LOC101157554	LOC101157726	ENSORLP00000016578	ENSORLP00000016266	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.558
LOC101157554	LOC101161410	ENSORLP00000016578	ENSORLP00000029280	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Surfactant protein Bb.	0.417
LOC101157554	cltc	ENSORLP00000016578	ENSORLP00000033788	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.900
LOC101157554	cltcl1	ENSORLP00000016578	ENSORLP00000002883	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.900
LOC101157554	flot2	ENSORLP00000016578	ENSORLP00000014302	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.558
LOC101157554	psap	ENSORLP00000016578	ENSORLP00000014346	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.	0.417
LOC101157726	LOC101155616	ENSORLP00000016266	ENSORLP00000008720	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.544
LOC101157726	LOC101157554	ENSORLP00000016266	ENSORLP00000016578	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.558
LOC101157726	LOC101164911	ENSORLP00000016266	ENSORLP00000002427	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.591
LOC101157726	cltc	ENSORLP00000016266	ENSORLP00000033788	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.563
LOC101157726	flot2	ENSORLP00000016266	ENSORLP00000014302	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.597
LOC101161410	LOC101157554	ENSORLP00000029280	ENSORLP00000016578	Surfactant protein Bb.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.417
LOC101161410	cltc	ENSORLP00000029280	ENSORLP00000033788	Surfactant protein Bb.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.417
LOC101161410	cltcl1	ENSORLP00000029280	ENSORLP00000002883	Surfactant protein Bb.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.417
LOC101161410	psap	ENSORLP00000029280	ENSORLP00000014346	Surfactant protein Bb.	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.	0.900