STRINGSTRING
atr atr topbp1 topbp1 kdm1a kdm1a cop1 cop1 sirt1 sirt1 LOC101168074 LOC101168074 zmpste24 zmpste24 Brcc3 Brcc3 stk11 stk11 IKBIP IKBIP bard1 bard1 ercc1 ercc1 xrcc5 xrcc5 bcl2 bcl2 LOC101165887 LOC101165887 SPIDR SPIDR map3k20 map3k20 cdca7 cdca7 rad51 rad51 ino80 ino80 babam2 babam2 Atm Atm ENSORLP00000026921 ENSORLP00000026921 blm blm ENSORLP00000027128 ENSORLP00000027128 ENSORLP00000027276 ENSORLP00000027276 ENSORLP00000027619 ENSORLP00000027619 ENSORLP00000027695 ENSORLP00000027695 ENSORLP00000027785 ENSORLP00000027785 xrcc2 xrcc2 ENSORLP00000045767 ENSORLP00000045767 ENSORLP00000028101 ENSORLP00000028101 LOC101157631 LOC101157631 abraxas1 abraxas1 rad9b rad9b tank tank ENSORLP00000044186 ENSORLP00000044186 ENSORLP00000043739 ENSORLP00000043739 ENSORLP00000043737 ENSORLP00000043737 LOC101175080 LOC101175080 smpd1 smpd1 abcg5 abcg5 LOC101171668 LOC101171668 rad1 rad1 LOC101169800 LOC101169800 ENSORLP00000043225 ENSORLP00000043225 LOC101172571 LOC101172571 ENSORLP00000042234 ENSORLP00000042234 ercc6 ercc6 ENSORLP00000041938 ENSORLP00000041938 ENSORLP00000041457 ENSORLP00000041457 ENSORLP00000041309 ENSORLP00000041309 LOC101166932 LOC101166932 ENSORLP00000040440 ENSORLP00000040440 LOC101168687 LOC101168687 uimc1 uimc1 LOC101159022 LOC101159022 ENSORLP00000039392 ENSORLP00000039392 brca2 brca2 LOC101160620 LOC101160620 ENSORLP00000037754 ENSORLP00000037754 ENSORLP00000037569 ENSORLP00000037569 ENSORLP00000037560 ENSORLP00000037560 ENSORLP00000037357 ENSORLP00000037357 lig4 lig4 ENSORLP00000037248 ENSORLP00000037248 ENSORLP00000037118 ENSORLP00000037118 ENSORLP00000036193 ENSORLP00000036193 ENSORLP00000036064 ENSORLP00000036064 ENSORLP00000035982 ENSORLP00000035982 dcun1d3 dcun1d3 rhno1 rhno1 ptprc ptprc ENSORLP00000035462 ENSORLP00000035462 ENSORLP00000034792 ENSORLP00000034792 ENSORLP00000034408 ENSORLP00000034408 ENSORLP00000034031 ENSORLP00000034031 ENSORLP00000034014 ENSORLP00000034014 tp53bp1 tp53bp1 LOC101167675 LOC101167675 ENSORLP00000032954 ENSORLP00000032954 ticrr ticrr ints3 ints3 xrcc6 xrcc6 rad9a rad9a CDCA7L CDCA7L chek2 chek2 ENSORLP00000032709 ENSORLP00000032709 itgb6 itgb6 fbxo4 fbxo4 ENSORLP00000032655 ENSORLP00000032655 ENSORLP00000032456 ENSORLP00000032456 mfsd11 mfsd11 ENSORLP00000031965 ENSORLP00000031965 ENSORLP00000031530 ENSORLP00000031530 rad51ap1 rad51ap1 ENSORLP00000030024 ENSORLP00000030024 ect2 ect2 ENSORLP00000029565 ENSORLP00000029565 ENSORLP00000029266 ENSORLP00000029266 ENSORLP00000029104 ENSORLP00000029104 ENSORLP00000028582 ENSORLP00000028582 ENSORLP00000028253 ENSORLP00000028253 ercc8 ercc8 brca1 brca1 rfwd3 rfwd3 xrra1 xrra1 kars1 kars1 sfrp2 sfrp2 LOC101170629 LOC101170629 brat1 brat1 babam1 babam1 LOC100049216 LOC100049216 msh2 msh2 LOC101171428 LOC101171428 inip inip men1 men1 rnf8 rnf8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2160 aa)
topbp1DNA topoisomerase II binding protein 1. (1460 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (860 aa)
cop1COP1 E3 ubiquitin ligase. (705 aa)
sirt1Deacetylase sirtuin-type domain-containing protein. (680 aa)
LOC101168074Mitogen-activated protein kinase kinase kinase 20. (666 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (467 aa)
Brcc3BRCA1/BRCA2-containing complex, subunit 3. (296 aa)
stk11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
IKBIPIKBKB interacting protein. (404 aa)
bard1BRCA1 associated RING domain 1. (798 aa)
ercc1Excision repair cross-complementation group 1. (341 aa)
xrcc5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (725 aa)
bcl2BCL2 apoptosis regulator b. (202 aa)
LOC101165887ETS transcription factor ELK1. (571 aa)
SPIDRScaffold protein involved in DNA repair. (885 aa)
map3k20Uncharacterized protein. (802 aa)
cdca7Cell division cycle associated 7a. (391 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (396 aa)
ino80INO80 complex ATPase subunit. (1547 aa)
babam2BRISC and BRCA1 A complex member 2. (386 aa)
AtmUncharacterized protein. (147 aa)
ENSORLP00000026921Reverse transcriptase domain-containing protein. (1102 aa)
blmUncharacterized protein. (1393 aa)
ENSORLP00000027128Reverse transcriptase domain-containing protein. (851 aa)
ENSORLP00000027276Reverse transcriptase domain-containing protein. (1441 aa)
ENSORLP00000027619TAN domain-containing protein. (321 aa)
ENSORLP00000027695Reverse transcriptase domain-containing protein. (1076 aa)
ENSORLP00000027785Reverse transcriptase domain-containing protein. (902 aa)
xrcc2X-ray repair cross complementing 2. (313 aa)
ENSORLP00000045767Reverse transcriptase domain-containing protein. (1239 aa)
ENSORLP00000028101Reverse transcriptase domain-containing protein. (1240 aa)
LOC101157631Transforming growth factor beta; Belongs to the TGF-beta family. (444 aa)
abraxas1Abraxas 1, BRCA1 A complex subunit. (387 aa)
rad9bRAD9 checkpoint clamp component B. (402 aa)
tankTRAF family member-associated NFKB activator. (345 aa)
ENSORLP00000044186Reverse transcriptase domain-containing protein. (1243 aa)
ENSORLP00000043739Reverse transcriptase domain-containing protein. (805 aa)
ENSORLP00000043737Reverse transcriptase domain-containing protein. (1243 aa)
LOC101175080DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1430 aa)
smpd1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (604 aa)
abcg5ATP-binding cassette, sub-family G (WHITE), member 5. (638 aa)
LOC101171668Uncharacterized protein. (446 aa)
rad1RAD1 homolog (S. pombe). (282 aa)
LOC101169800Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family. (161 aa)
ENSORLP00000043225Reverse transcriptase domain-containing protein. (968 aa)
LOC101172571FA complementation group D2. (1518 aa)
ENSORLP00000042234Reverse transcriptase domain-containing protein. (1248 aa)
ercc6Excision repair cross-complementation group 6. (1342 aa)
ENSORLP00000041938Reverse transcriptase domain-containing protein. (1249 aa)
ENSORLP00000041457Reverse transcriptase domain-containing protein. (891 aa)
ENSORLP00000041309Reverse transcriptase domain-containing protein. (800 aa)
LOC101166932X-ray repair complementing defective repair in Chinese hamster cells 4. (336 aa)
ENSORLP00000040440Reverse transcriptase domain-containing protein. (1236 aa)
LOC101168687Zgc:153993. (293 aa)
uimc1Uncharacterized protein. (838 aa)
LOC101159022Uncharacterized protein. (298 aa)
ENSORLP00000039392Reverse transcriptase domain-containing protein. (1262 aa)
brca2BRCA2 DNA repair associated. (3161 aa)
LOC101160620Deoxyribonuclease 1 like 4, tandem duplicate 2. (364 aa)
ENSORLP00000037754Reverse transcriptase domain-containing protein. (923 aa)
ENSORLP00000037569Reverse transcriptase domain-containing protein. (1153 aa)
ENSORLP00000037560Reverse transcriptase domain-containing protein. (772 aa)
ENSORLP00000037357Reverse transcriptase domain-containing protein. (1203 aa)
lig4DNA ligase. (912 aa)
ENSORLP00000037248Reverse transcriptase domain-containing protein. (938 aa)
ENSORLP00000037118annotation not available (1248 aa)
ENSORLP00000036193Reverse transcriptase domain-containing protein. (1249 aa)
ENSORLP00000036064Reverse transcriptase domain-containing protein. (1025 aa)
ENSORLP00000035982Reverse transcriptase domain-containing protein. (1283 aa)
dcun1d3DCN1-like protein. (325 aa)
rhno1Si:ch73-352p4.5. (266 aa)
ptprcProtein tyrosine phosphatase receptor type C. (1343 aa)
ENSORLP00000035462Reverse transcriptase domain-containing protein. (855 aa)
ENSORLP00000034792Reverse transcriptase domain-containing protein. (845 aa)
ENSORLP00000034408Reverse transcriptase domain-containing protein. (961 aa)
ENSORLP00000034031Reverse transcriptase domain-containing protein. (1278 aa)
ENSORLP00000034014Reverse transcriptase domain-containing protein. (1314 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1583 aa)
LOC101167675Deoxyribonuclease 1 like 4, tandem duplicate 2. (219 aa)
ENSORLP00000032954Reverse transcriptase domain-containing protein. (1115 aa)
ticrrTreslin_N domain-containing protein. (1831 aa)
ints3Integrator complex subunit 3. (1019 aa)
xrcc6X-ray repair complementing defective repair in Chinese hamster cells 6. (611 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (388 aa)
CDCA7Lzf-4CXXC_R1 domain-containing protein. (414 aa)
chek2Checkpoint kinase 2. (526 aa)
ENSORLP00000032709Reverse transcriptase domain-containing protein. (444 aa)
itgb6Integrin beta; Belongs to the integrin beta chain family. (757 aa)
fbxo4F-box protein 4. (405 aa)
ENSORLP00000032655Reverse transcriptase domain-containing protein. (1262 aa)
ENSORLP00000032456Reverse transcriptase domain-containing protein. (1248 aa)
mfsd11Major facilitator superfamily domain containing 11. (450 aa)
ENSORLP00000031965Reverse transcriptase domain-containing protein. (1239 aa)
ENSORLP00000031530Reverse transcriptase domain-containing protein. (1095 aa)
rad51ap1RAD51 associated protein 1. (315 aa)
ENSORLP00000030024Reverse transcriptase domain-containing protein. (1000 aa)
ect2Epithelial cell transforming 2. (1098 aa)
ENSORLP00000029565Reverse transcriptase domain-containing protein. (925 aa)
ENSORLP00000029266Reverse transcriptase domain-containing protein. (1253 aa)
ENSORLP00000029104Uncharacterized protein. (101 aa)
ENSORLP00000028582Reverse transcriptase domain-containing protein. (1003 aa)
ENSORLP00000028253Reverse transcriptase domain-containing protein. (1038 aa)
ercc8Excision repair cross-complementation group 8. (401 aa)
brca1Uncharacterized protein. (1292 aa)
rfwd3Ring finger and WD repeat domain 3. (702 aa)
xrra1X-ray radiation resistance associated 1. (602 aa)
kars1Lysine--tRNA ligase. (611 aa)
sfrp2Secreted frizzled-related protein 2. (290 aa)
LOC101170629Nucleic acid binding protein 1a. (210 aa)
brat1BRCA1-associated ATM activator 1. (872 aa)
babam1BRISC and BRCA1 A complex member 1. (377 aa)
LOC100049216Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (574 aa)
msh2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
LOC101171428FZ domain-containing protein. (337 aa)
inipInts3 and nabp interacting protein. (102 aa)
men1Multiple endocrine neoplasia I. (691 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (516 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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