(22 nodes) Response to gamma radiation network (Oryzias latipes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	LOC101172571	FA complementation group D2. (1518 aa)
	xrcc6	X-ray repair complementing defective repair in Chinese hamster cells 6. (611 aa)
	LOC101169800	Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family. (161 aa)
	men1	Multiple endocrine neoplasia I. (691 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2160 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (860 aa)
	LOC101168074	Mitogen-activated protein kinase kinase kinase 20. (666 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (467 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (725 aa)
	bcl2	BCL2 apoptosis regulator b. (202 aa)
	xrcc2	X-ray repair cross complementing 2. (313 aa)
	LOC101165887	ETS transcription factor ELK1. (571 aa)
	map3k20	Uncharacterized protein. (802 aa)
	Atm	Uncharacterized protein. (147 aa)
	ENSORLP00000027619	TAN domain-containing protein. (321 aa)
	chek2	Checkpoint kinase 2. (526 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1343 aa)
	dcun1d3	DCN1-like protein. (325 aa)
	lig4	DNA ligase. (912 aa)
	brca2	BRCA2 DNA repair associated. (3161 aa)
	LOC101168687	Zgc:153993. (293 aa)
	ercc6	Excision repair cross-complementation group 6. (1342 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atm	ENSORLP00000027619	ENSORLP00000026266	ENSORLP00000027619	Uncharacterized protein.	TAN domain-containing protein.	0.929
Atm	LOC101172571	ENSORLP00000026266	ENSORLP00000042398	Uncharacterized protein.	FA complementation group D2.	0.609
Atm	atr	ENSORLP00000026266	ENSORLP00000015251	Uncharacterized protein.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.968
Atm	brca2	ENSORLP00000026266	ENSORLP00000039367	Uncharacterized protein.	BRCA2 DNA repair associated.	0.832
Atm	chek2	ENSORLP00000026266	ENSORLP00000032936	Uncharacterized protein.	Checkpoint kinase 2.	0.993
Atm	lig4	ENSORLP00000026266	ENSORLP00000037330	Uncharacterized protein.	DNA ligase.	0.620
Atm	xrcc2	ENSORLP00000026266	ENSORLP00000045844	Uncharacterized protein.	X-ray repair cross complementing 2.	0.682
Atm	xrcc5	ENSORLP00000026266	ENSORLP00000020528	Uncharacterized protein.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.890
Atm	xrcc6	ENSORLP00000026266	ENSORLP00000003026	Uncharacterized protein.	X-ray repair complementing defective repair in Chinese hamster cells 6.	0.907
ENSORLP00000027619	Atm	ENSORLP00000027619	ENSORLP00000026266	TAN domain-containing protein.	Uncharacterized protein.	0.929
ENSORLP00000027619	LOC101172571	ENSORLP00000027619	ENSORLP00000042398	TAN domain-containing protein.	FA complementation group D2.	0.609
ENSORLP00000027619	atr	ENSORLP00000027619	ENSORLP00000015251	TAN domain-containing protein.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.968
ENSORLP00000027619	brca2	ENSORLP00000027619	ENSORLP00000039367	TAN domain-containing protein.	BRCA2 DNA repair associated.	0.832
ENSORLP00000027619	chek2	ENSORLP00000027619	ENSORLP00000032936	TAN domain-containing protein.	Checkpoint kinase 2.	0.938
ENSORLP00000027619	lig4	ENSORLP00000027619	ENSORLP00000037330	TAN domain-containing protein.	DNA ligase.	0.620
ENSORLP00000027619	xrcc2	ENSORLP00000027619	ENSORLP00000045844	TAN domain-containing protein.	X-ray repair cross complementing 2.	0.682
ENSORLP00000027619	xrcc5	ENSORLP00000027619	ENSORLP00000020528	TAN domain-containing protein.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.890
ENSORLP00000027619	xrcc6	ENSORLP00000027619	ENSORLP00000003026	TAN domain-containing protein.	X-ray repair complementing defective repair in Chinese hamster cells 6.	0.907
LOC101168074	map3k20	ENSORLP00000018072	ENSORLP00000021833	Mitogen-activated protein kinase kinase kinase 20.	Uncharacterized protein.	0.902
LOC101168687	bcl2	ENSORLP00000040142	ENSORLP00000021005	Zgc:153993.	BCL2 apoptosis regulator b.	0.856