(45 nodes) Negative regulation of autophagy network (Oryzias latipes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	phf23	PHD finger protein 23b. (334 aa)
	lepa	Leptin-A; May function as part of a signaling pathway that acts to regulate the size of the body fat depot. (185 aa)
	dap	Death-associated protein. (107 aa)
	H2L4B7_ORYLA	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (737 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1023 aa)
	LOC101160321	Forkhead box K2. (606 aa)
	tmem39a	Transmembrane protein 39A. (495 aa)
	htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (473 aa)
	ctsa	Carboxypeptidase; Belongs to the peptidase S10 family. (471 aa)
	poldip2	Polymerase (DNA-directed), delta interacting protein 2. (375 aa)
	scfd1	Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (631 aa)
	TSC2	TSC complex subunit 2. (1608 aa)
	nrbp2	Nuclear receptor binding protein 2b. (512 aa)
	LOC101160853	Uncharacterized protein. (591 aa)
	klhl22	Kelch-like family member 22. (621 aa)
	tsc1	TSC complex subunit 1b. (1198 aa)
	il10	Interleukin 10. (181 aa)
	cptp	Ceramide-1-phosphate transfer protein. (218 aa)
	pink1	PTEN induced kinase 1. (577 aa)
	bcl2	BCL2 apoptosis regulator b. (202 aa)
	fez2	Si:ch211-57i17.1. (398 aa)
	tmem39b	Transmembrane protein 39B. (488 aa)
	fez1	Fasciculation and elongation protein zeta 1 (zygin I). (405 aa)
	H2MY57_ORYLA	FATC domain-containing protein. (287 aa)
	Smg1	SMG1_N domain-containing protein. (764 aa)
	tspo	Translocator protein. (161 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2241 aa)
	clec16a	C-type lectin domain containing 16A. (1094 aa)
	wdr6	WD repeat domain 6. (1379 aa)
	foxk1	Uncharacterized protein. (676 aa)
	ENSORLP00000029335	Nuclear protein 1a. (76 aa)
	LOC101162799	Zgc:154055. (558 aa)
	ENSORLP00000031311	Uncharacterized protein. (248 aa)
	Tsc2	DUF3384 domain-containing protein. (164 aa)
	lzts1	Leucine zipper, putative tumor suppressor 1. (651 aa)
	dapl1	Uncharacterized protein. (146 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (378 aa)
	mtmr9	Myotubularin related protein 9. (549 aa)
	rubcn	Rubicon autophagy regulator. (973 aa)
	ENSORLP00000036489	Uncharacterized protein. (148 aa)
	bmf	Uncharacterized protein. (169 aa)
	LOC101155054	Si:dkey-288i20.2. (365 aa)
	LOC101168356	Carboxypeptidase; Belongs to the peptidase S10 family. (459 aa)
	lepr	Leptin recepter. (1074 aa)
	ENSORLP00000043605	Uncharacterized protein. (173 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000031311	H2L4B7_ORYLA	ENSORLP00000031311	ENSORLP00000000606	Uncharacterized protein.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.850
ENSORLP00000031311	H2MY57_ORYLA	ENSORLP00000031311	ENSORLP00000023915	Uncharacterized protein.	FATC domain-containing protein.	0.632
ENSORLP00000031311	Mtor	ENSORLP00000031311	ENSORLP00000000608	Uncharacterized protein.	Serine/threonine-protein kinase TOR.	0.850
ENSORLP00000031311	Smg1	ENSORLP00000031311	ENSORLP00000023938	Uncharacterized protein.	SMG1_N domain-containing protein.	0.632
ENSORLP00000031311	TSC2	ENSORLP00000031311	ENSORLP00000014632	Uncharacterized protein.	TSC complex subunit 2.	0.968
ENSORLP00000031311	Tsc2	ENSORLP00000031311	ENSORLP00000032706	Uncharacterized protein.	DUF3384 domain-containing protein.	0.993
ENSORLP00000031311	pink1	ENSORLP00000031311	ENSORLP00000020035	Uncharacterized protein.	PTEN induced kinase 1.	0.549
ENSORLP00000031311	tsc1	ENSORLP00000031311	ENSORLP00000018027	Uncharacterized protein.	TSC complex subunit 1b.	0.545
ENSORLP00000043605	bcl2	ENSORLP00000043605	ENSORLP00000021005	Uncharacterized protein.	BCL2 apoptosis regulator b.	0.796
H2L4B7_ORYLA	ENSORLP00000031311	ENSORLP00000000606	ENSORLP00000031311	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.850
H2L4B7_ORYLA	H2MY57_ORYLA	ENSORLP00000000606	ENSORLP00000023915	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	FATC domain-containing protein.	0.894
H2L4B7_ORYLA	Mtor	ENSORLP00000000606	ENSORLP00000000608	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.968
H2L4B7_ORYLA	Smg1	ENSORLP00000000606	ENSORLP00000023938	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	SMG1_N domain-containing protein.	0.895
H2L4B7_ORYLA	TSC2	ENSORLP00000000606	ENSORLP00000014632	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	TSC complex subunit 2.	0.786
H2L4B7_ORYLA	Tsc2	ENSORLP00000000606	ENSORLP00000032706	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	DUF3384 domain-containing protein.	0.786
H2L4B7_ORYLA	tsc1	ENSORLP00000000606	ENSORLP00000018027	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	TSC complex subunit 1b.	0.850
H2MY57_ORYLA	ENSORLP00000031311	ENSORLP00000023915	ENSORLP00000031311	FATC domain-containing protein.	Uncharacterized protein.	0.632
H2MY57_ORYLA	H2L4B7_ORYLA	ENSORLP00000023915	ENSORLP00000000606	FATC domain-containing protein.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.894
H2MY57_ORYLA	Smg1	ENSORLP00000023915	ENSORLP00000023938	FATC domain-containing protein.	SMG1_N domain-containing protein.	0.934
H2MY57_ORYLA	TSC2	ENSORLP00000023915	ENSORLP00000014632	FATC domain-containing protein.	TSC complex subunit 2.	0.649