(47 nodes) Regulation of cellular ketone metabolic process network (Oryzias latipes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ncor1	Nuclear receptor corepressor 1. (2380 aa)
	ENSORLP00000045591	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (130 aa)
	lpgat1	Lysophosphatidylglycerol acyltransferase 1. (539 aa)
	ENSORLP00000043858	Si:ch211-272n13.3. (250 aa)
	ENSORLP00000042504	Dickkopf WNT signaling pathway inhibitor 3b. (307 aa)
	ppara	Uncharacterized protein. (480 aa)
	h6pd	Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase). (810 aa)
	pdk1	Protein-serine/threonine kinase. (413 aa)
	LOC101169209	Uncharacterized protein. (283 aa)
	pparg	Uncharacterized protein. (549 aa)
	pdk4	Protein-serine/threonine kinase. (410 aa)
	coq3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (328 aa)
	scap	SREBF chaperone. (1355 aa)
	ppard	Uncharacterized protein. (517 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (469 aa)
	wdtc1	WD and tetratricopeptide repeats 1. (674 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (311 aa)
	DGKQ	Diacylglycerol kinase. (908 aa)
	LOC101169237	ATCAY kinesin light chain interacting caytaxin b. (305 aa)
	LOC101164549	ATCAY kinesin light chain interacting caytaxin a. (369 aa)
	cln3	Battenin. (437 aa)
	LOC101163111	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (304 aa)
	fh	Fumarate hydratase. (499 aa)
	etfbkmt	Electron transfer flavoprotein subunit beta lysine methyltransferase. (335 aa)
	PPTC7	Protein phosphatase; Belongs to the PP2C family. (297 aa)
	mlycd	Malonyl-CoA decarboxylase. (502 aa)
	LOC101169721	Apolipoprotein A-Ib. (323 aa)
	LOC101174341	Nuclear receptor subfamily 1, group D, member 4b. (568 aa)
	ncor2	Nuclear receptor corepressor 2. (2180 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (680 aa)
	sirt5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (332 aa)
	LOC101175202	Protein-serine/threonine kinase. (408 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (485 aa)
	ptgs2	EGF-like domain-containing protein. (607 aa)
	LOC101169795	Protein phosphatase; Belongs to the PP2C family. (297 aa)
	LOC101173669	ATP-binding cassette, sub-family D (ALD), member 2. (734 aa)
	pdk3	Protein-serine/threonine kinase. (406 aa)
	LOC101157602	Dickkopf WNT signaling pathway inhibitor 3a. (266 aa)
	tysnd1	Trypsin domain containing 1. (526 aa)
	pibf1	Progesterone immunomodulatory binding factor 1. (749 aa)
	brca1	Uncharacterized protein. (1292 aa)
	dab2	DAB adaptor protein 2. (761 aa)
	Ankrd26	CCDC144C domain-containing protein. (283 aa)
	H2L8Z5_ORYLA	DUF3496 domain-containing protein. (481 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (462 aa)
	prmt3	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (524 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ankrd26	ENSORLP00000043858	ENSORLP00000002329	ENSORLP00000043858	CCDC144C domain-containing protein.	Si:ch211-272n13.3.	0.893
Ankrd26	H2L8Z5_ORYLA	ENSORLP00000002329	ENSORLP00000002328	CCDC144C domain-containing protein.	DUF3496 domain-containing protein.	0.880
ENSORLP00000042504	dab2	ENSORLP00000042504	ENSORLP00000003668	Dickkopf WNT signaling pathway inhibitor 3b.	DAB adaptor protein 2.	0.424
ENSORLP00000043858	Ankrd26	ENSORLP00000043858	ENSORLP00000002329	Si:ch211-272n13.3.	CCDC144C domain-containing protein.	0.893
ENSORLP00000043858	H2L8Z5_ORYLA	ENSORLP00000043858	ENSORLP00000002328	Si:ch211-272n13.3.	DUF3496 domain-containing protein.	0.825
H2L8Z5_ORYLA	Ankrd26	ENSORLP00000002328	ENSORLP00000002329	DUF3496 domain-containing protein.	CCDC144C domain-containing protein.	0.880
H2L8Z5_ORYLA	ENSORLP00000043858	ENSORLP00000002328	ENSORLP00000043858	DUF3496 domain-containing protein.	Si:ch211-272n13.3.	0.825
LOC101157602	dab2	ENSORLP00000009363	ENSORLP00000003668	Dickkopf WNT signaling pathway inhibitor 3a.	DAB adaptor protein 2.	0.424
LOC101163111	ncor1	ENSORLP00000021504	ENSORLP00000015017	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Nuclear receptor corepressor 1.	0.465
LOC101163111	ncor2	ENSORLP00000021504	ENSORLP00000017559	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Nuclear receptor corepressor 2.	0.465
LOC101163111	sirt4	ENSORLP00000021504	ENSORLP00000024755	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.506
LOC101169209	ptgs2	ENSORLP00000036862	ENSORLP00000011865	Uncharacterized protein.	EGF-like domain-containing protein.	0.751
LOC101169209	sirt1	ENSORLP00000036862	ENSORLP00000017142	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.445
LOC101174341	ncor1	ENSORLP00000019274	ENSORLP00000015017	Nuclear receptor subfamily 1, group D, member 4b.	Nuclear receptor corepressor 1.	0.929
LOC101174341	ncor2	ENSORLP00000019274	ENSORLP00000017559	Nuclear receptor subfamily 1, group D, member 4b.	Nuclear receptor corepressor 2.	0.929
LOC101175202	h6pd	ENSORLP00000015232	ENSORLP00000040383	Protein-serine/threonine kinase.	Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase).	0.517
LOC101175202	tysnd1	ENSORLP00000015232	ENSORLP00000008523	Protein-serine/threonine kinase.	Trypsin domain containing 1.	0.427
PPARA	ncor1	ENSORLP00000029840	ENSORLP00000015017	Peroxisome proliferator-activated receptor alpha b.	Nuclear receptor corepressor 1.	0.806
PPARA	ncor2	ENSORLP00000029840	ENSORLP00000017559	Peroxisome proliferator-activated receptor alpha b.	Nuclear receptor corepressor 2.	0.806
PPARA	nr1h3	ENSORLP00000029840	ENSORLP00000001581	Peroxisome proliferator-activated receptor alpha b.	Nuclear receptor subfamily 1, group H, member 3.	0.531