(30 nodes) Regulation of necrotic cell death network (Oryzias latipes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	MUTYH	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (522 aa)
	hebp3	Heme-binding protein 3. (213 aa)
	LOC101166217	RanBP-type and C3HC4-type zinc finger containing 1. (518 aa)
	LOC101162956	Si:dkey-181m9.8. (768 aa)
	LOC101168078	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily. (481 aa)
	spata2	Spermatogenesis associated 2. (568 aa)
	LOC100125536	Uncharacterized protein; Belongs to the peptidase C14A family. (389 aa)
	casp8	Uncharacterized protein; Belongs to the peptidase C14A family. (481 aa)
	LOC101174057	Uncharacterized protein. (1112 aa)
	atg9a	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (850 aa)
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (918 aa)
	LOC101163809	Cylindromatosis (turban tumor syndrome), b. (707 aa)
	cflar	FLICE-like inhibitory protein; Belongs to the peptidase C14A family. (460 aa)
	ripk1	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (675 aa)
	LOC101155382	Uncharacterized protein. (1085 aa)
	LOC101163059	Uncharacterized protein. (192 aa)
	ENSORLP00000029335	Nuclear protein 1a. (76 aa)
	LOC101168038	Protein kinase domain-containing protein. (509 aa)
	asah1	N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family. (392 aa)
	LOC101168285	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (415 aa)
	LOC101163130	Heme binding protein 2. (192 aa)
	LOC101168449	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family. (769 aa)
	ucn	Urotensin 1. (132 aa)
	adprhl2	ADP-ribosylhydrolase like 2. (378 aa)
	LOC101154833	Uncharacterized protein. (192 aa)
	LOC101167576	Uncharacterized protein. (943 aa)
	LOC101175197	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (809 aa)
	fadd	Uncharacterized protein. (192 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (292 aa)
	ENSORLP00000045591	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (130 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP6	LOC100125536	ENSORLP00000044560	ENSORLP00000013993	Caspase 6; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.951
CASP6	LOC101168038	ENSORLP00000044560	ENSORLP00000029474	Caspase 6; Belongs to the peptidase C14A family.	Protein kinase domain-containing protein.	0.460
CASP6	LOC101168078	ENSORLP00000044560	ENSORLP00000011349	Caspase 6; Belongs to the peptidase C14A family.	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily.	0.460
CASP6	LOC101168285	ENSORLP00000044560	ENSORLP00000029843	Caspase 6; Belongs to the peptidase C14A family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.460
CASP6	casp8	ENSORLP00000044560	ENSORLP00000014046	Caspase 6; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.976
CASP6	fadd	ENSORLP00000044560	ENSORLP00000043356	Caspase 6; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.551
CASP6	ripk1	ENSORLP00000044560	ENSORLP00000026458	Caspase 6; Belongs to the peptidase C14A family.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.408
LOC100125536	CASP6	ENSORLP00000013993	ENSORLP00000044560	Uncharacterized protein; Belongs to the peptidase C14A family.	Caspase 6; Belongs to the peptidase C14A family.	0.951
LOC100125536	LOC101163809	ENSORLP00000013993	ENSORLP00000017400	Uncharacterized protein; Belongs to the peptidase C14A family.	Cylindromatosis (turban tumor syndrome), b.	0.918
LOC100125536	LOC101167576	ENSORLP00000013993	ENSORLP00000038710	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.918
LOC100125536	LOC101168038	ENSORLP00000013993	ENSORLP00000029474	Uncharacterized protein; Belongs to the peptidase C14A family.	Protein kinase domain-containing protein.	0.983
LOC100125536	LOC101168078	ENSORLP00000013993	ENSORLP00000011349	Uncharacterized protein; Belongs to the peptidase C14A family.	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily.	0.985
LOC100125536	LOC101168285	ENSORLP00000013993	ENSORLP00000029843	Uncharacterized protein; Belongs to the peptidase C14A family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.983
LOC100125536	LOC101168449	ENSORLP00000013993	ENSORLP00000036637	Uncharacterized protein; Belongs to the peptidase C14A family.	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family.	0.918
LOC100125536	casp8	ENSORLP00000013993	ENSORLP00000014046	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.905
LOC100125536	cflar	ENSORLP00000013993	ENSORLP00000020363	Uncharacterized protein; Belongs to the peptidase C14A family.	FLICE-like inhibitory protein; Belongs to the peptidase C14A family.	0.994
LOC100125536	cyld	ENSORLP00000013993	ENSORLP00000017385	Uncharacterized protein; Belongs to the peptidase C14A family.	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	0.918
LOC100125536	fadd	ENSORLP00000013993	ENSORLP00000043356	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.996
LOC100125536	ripk1	ENSORLP00000013993	ENSORLP00000026458	Uncharacterized protein; Belongs to the peptidase C14A family.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.996
LOC101155382	LOC101162956	ENSORLP00000026609	ENSORLP00000010289	Uncharacterized protein.	Si:dkey-181m9.8.	0.904