(40 nodes) Positive regulation of phosphatidylinositol 3-kinase signaling network (Oryzias latipes)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	ntrk3	Tyrosine-protein kinase receptor. (815 aa)
	LOC101175634	Myocilin. (570 aa)
	LOC101155037	Transforming growth factor beta; Belongs to the TGF-beta family. (420 aa)
	H2LIM0_ORYLA	Uncharacterized protein. (726 aa)
	ntrk2	Tyrosine-protein kinase receptor. (745 aa)
	agt	Angiotensinogen; Belongs to the serpin family. (460 aa)
	LOC105356557	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (393 aa)
	pdgfa	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (227 aa)
	ror1	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (954 aa)
	LOC101171139	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (199 aa)
	unc5b	Unc-5 netrin receptor B. (949 aa)
	LOC101165149	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (510 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (680 aa)
	pik3ap1	Phosphoinositide-3-kinase adaptor protein 1. (915 aa)
	dcn	Decorin; May affect the rate of fibrils formation. (367 aa)
	LOC101165876	Ubiquitin protein ligase E3A. (814 aa)
	LOC101173752	IGv domain-containing protein. (224 aa)
	wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	fn1	Fibronectin-1. (2503 aa)
	ENSORLP00000026165	Kringle domain-containing protein. (94 aa)
	pdgfb	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (553 aa)
	ENSORLP00000027787	Neurotrophic tyrosine kinase, receptor, type 2b. (433 aa)
	ENSORLP00000029099	Uncharacterized protein. (282 aa)
	ncf1	Neutrophil cytosolic factor 1. (421 aa)
	ppard	Uncharacterized protein. (517 aa)
	ror2	Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (938 aa)
	hax1	HCLS1 associated protein X-1. (282 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (894 aa)
	LOC101170246	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (617 aa)
	LOC101167634	Coagulation factor II thrombin receptor. (440 aa)
	ENSORLP00000034659	Reelin domain-containing protein. (259 aa)
	pdgfc	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (342 aa)
	LOC101167461	NK3 homeobox 1. (188 aa)
	LOC101168685	Tyrosine-protein kinase receptor. (816 aa)
	LOC101172297	Uncharacterized protein. (488 aa)
	ntrk1	Tyrosine-protein kinase receptor. (689 aa)
	MYOC	Myocilin. (458 aa)
	ARHGAP8	Rho GTPase activating protein 8. (407 aa)
	mydgf	Myeloid-derived growth factor. (205 aa)
	lepa	Leptin-A; May function as part of a signaling pathway that acts to regulate the size of the body fat depot. (185 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000026165	ENSORLP00000027787	ENSORLP00000026165	ENSORLP00000027787	Kringle domain-containing protein.	Neurotrophic tyrosine kinase, receptor, type 2b.	0.661
ENSORLP00000026165	dcn	ENSORLP00000026165	ENSORLP00000019171	Kringle domain-containing protein.	Decorin; May affect the rate of fibrils formation.	0.411
ENSORLP00000026165	ntrk1	ENSORLP00000026165	ENSORLP00000037973	Kringle domain-containing protein.	Tyrosine-protein kinase receptor.	0.661
ENSORLP00000026165	wnt16	ENSORLP00000026165	ENSORLP00000022913	Kringle domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.422
ENSORLP00000027787	ENSORLP00000026165	ENSORLP00000027787	ENSORLP00000026165	Neurotrophic tyrosine kinase, receptor, type 2b.	Kringle domain-containing protein.	0.661
ENSORLP00000027787	LOC101171139	ENSORLP00000027787	ENSORLP00000013046	Neurotrophic tyrosine kinase, receptor, type 2b.	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family.	0.663
ENSORLP00000027787	pdgfa	ENSORLP00000027787	ENSORLP00000010619	Neurotrophic tyrosine kinase, receptor, type 2b.	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family.	0.663
ENSORLP00000027787	pdgfb	ENSORLP00000027787	ENSORLP00000026229	Neurotrophic tyrosine kinase, receptor, type 2b.	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family.	0.671
ENSORLP00000027787	pdgfc	ENSORLP00000027787	ENSORLP00000035588	Neurotrophic tyrosine kinase, receptor, type 2b.	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family.	0.687
ENSORLP00000029099	ENSORLP00000034659	ENSORLP00000029099	ENSORLP00000034659	Uncharacterized protein.	Reelin domain-containing protein.	0.944
ENSORLP00000034659	ENSORLP00000029099	ENSORLP00000034659	ENSORLP00000029099	Reelin domain-containing protein.	Uncharacterized protein.	0.944
ENSORLP00000034659	H2LIM0_ORYLA	ENSORLP00000034659	ENSORLP00000005849	Reelin domain-containing protein.	Uncharacterized protein.	0.944
H2LIM0_ORYLA	ENSORLP00000034659	ENSORLP00000005849	ENSORLP00000034659	Uncharacterized protein.	Reelin domain-containing protein.	0.944
LOC101155037	dcn	ENSORLP00000002897	ENSORLP00000019171	Transforming growth factor beta; Belongs to the TGF-beta family.	Decorin; May affect the rate of fibrils formation.	0.946
LOC101165149	LOC101171139	ENSORLP00000016816	ENSORLP00000013046	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family.	0.749
LOC101165149	pdgfa	ENSORLP00000016816	ENSORLP00000010619	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family.	0.768
LOC101165149	pdgfc	ENSORLP00000016816	ENSORLP00000035588	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family.	0.738
LOC101165876	UBE3A	ENSORLP00000019736	ENSORLP00000033300	Ubiquitin protein ligase E3A.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.901
LOC101167634	LOC101170246	ENSORLP00000034567	ENSORLP00000033975	Coagulation factor II thrombin receptor.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.997
LOC101167634	agt	ENSORLP00000034567	ENSORLP00000006991	Coagulation factor II thrombin receptor.	Angiotensinogen; Belongs to the serpin family.	0.459