(77 nodes) Response to purine-containing compound network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSORLP00000045758	Uncharacterized protein. (409 aa)
	LOC101159216	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (527 aa)
	ryr1	Ryanodine receptor 1b (skeletal). (4677 aa)
	LOC101159013	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1106 aa)
	LOC101166974	Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family. (429 aa)
	crhbp	Corticotropin releasing hormone binding protein. (319 aa)
	LOC101157923	Insulin-like growth factor binding protein 5a. (253 aa)
	LOC101158674	cAMP responsive element binding protein 1. (315 aa)
	aqp8	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (258 aa)
	LOC101156980	Uncharacterized protein. (356 aa)
	HCN2	Hyperpolarization activated cyclic nucleotide-gated potassium channel 2b. (1028 aa)
	hsp90b1	Heat shock protein 90, beta (grp94), member 1. (796 aa)
	aanat2	Arylalkylamine N-acetyltransferase 2. (208 aa)
	LOC101164337	Ryanodine receptor 2b (cardiac). (4732 aa)
	duox1	Dual oxidase. (1477 aa)
	H2LLS9_ORYLA	Si:dkey-23i12.7. (111 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (454 aa)
	LOC101167529	RAP1A, member of RAS oncogene family b. (185 aa)
	p2ry1	Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	LOC101168057	Hyperpolarization activated cyclic nucleotide-gated potassium channel 1. (921 aa)
	p2rx2	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (412 aa)
	pik3cg	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1121 aa)
	cited1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1. (158 aa)
	H2M3H1_ORYLA	Si:dkey-6n21.13; Belongs to the G-protein coupled receptor 1 family. (385 aa)
	p2rx1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (419 aa)
	LOC101173001	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (461 aa)
	wt1	Uncharacterized protein. (435 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (860 aa)
	H2MD80_ORYLA	Hyperpolarization activated cyclic nucleotide-gated potassium channel 4. (1429 aa)
	LOC101165456	Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family. (381 aa)
	NT5E	5'-nucleotidase, ecto (CD73); Belongs to the 5'-nucleotidase family. (577 aa)
	LOC101172279	Cyclic nucleotide-binding domain-containing protein. (1151 aa)
	LOC101159259	Cyclic nucleotide-binding domain-containing protein. (1173 aa)
	LOC101158525	Rap guanine nucleotide exchange factor (GEF) 3. (798 aa)
	p2rx4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (464 aa)
	rapgef1	Uncharacterized protein. (881 aa)
	H2MR15_ORYLA	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (514 aa)
	kcnj8	Potassium inwardly-rectifying channel, subfamily J, member 8. (417 aa)
	LOC101172864	Uncharacterized protein. (255 aa)
	NT5E-2	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (581 aa)
	aqp1	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (261 aa)
	H2MVY7_ORYLA	Uncharacterized protein. (1008 aa)
	DGKQ	Diacylglycerol kinase. (908 aa)
	akap7	Uncharacterized protein. (501 aa)
	aanat	N-acetyltransferase domain-containing protein. (216 aa)
	rapgef2	Rap guanine nucleotide exchange factor (GEF) 2. (1630 aa)
	nox5	NADPH oxidase, EF-hand calcium binding domain 5. (807 aa)
	LOC101158464	Rap guanine nucleotide exchange factor (GEF) 1b. (1184 aa)
	LOC101164105	cAMP responsive element binding protein 1b. (329 aa)
	fosl1	FOS-like antigen 1a. (340 aa)
	ENSORLP00000031669	BZIP domain-containing protein. (91 aa)
	ENSORLP00000033268	Ins145_P3_rec domain-containing protein. (135 aa)
	LOC101157708	Hyperpolarization activated cyclic nucleotide-gated potassium channel 3. (622 aa)
	ENSORLP00000033307	Uncharacterized protein. (126 aa)
	bckdhb	Branched chain keto acid dehydrogenase E1 subunit beta. (389 aa)
	LOC101166715	Uncharacterized protein; Belongs to the potassium channel family. (719 aa)
	LOC101169121	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta. (924 aa)
	p2rx3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
	aanat1b	Arylalkylamine N-acetyltransferase 1b. (226 aa)
	LOC101158796	Cyclic nucleotide-binding domain-containing protein. (1445 aa)
	wt1-2	Uncharacterized protein. (418 aa)
	P2RY6	Pyrimidinergic receptor P2Y6. (379 aa)
	ndufs4	NADH:ubiquinone oxidoreductase subunit S4. (178 aa)
	p2ry12	Purinergic receptor P2Y12. (359 aa)
	akap6	A kinase (PRKA) anchor protein 6. (2292 aa)
	xrn1	5'-3' exoribonuclease 1. (1731 aa)
	ENSORLP00000041349	Ins145_P3_rec domain-containing protein. (123 aa)
	LOC101155067	Insulin-like growth factor binding protein 5a. (266 aa)
	LOC101171247	RAP1A, member of RAS oncogene family a. (202 aa)
	Kcnj11	Potassium inwardly-rectifying channel, subfamily J, member 11. (269 aa)
	LOC101161327	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (462 aa)
	eef2k	Eukaryotic elongation factor 2 kinase. (758 aa)
	Ryr3	B30.2/SPRY domain-containing protein. (298 aa)
	LOC101161541	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (695 aa)
	LOC101157884	BZIP domain-containing protein. (177 aa)
	gata-1	Hematopietic transcription factor GATA-1. (417 aa)
	LOC101174084	KID domain-containing protein. (205 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000031669	LOC101157884	ENSORLP00000031669	ENSORLP00000045455	BZIP domain-containing protein.	BZIP domain-containing protein.	0.550
ENSORLP00000031669	LOC101158674	ENSORLP00000031669	ENSORLP00000002934	BZIP domain-containing protein.	cAMP responsive element binding protein 1.	0.553
ENSORLP00000031669	LOC101164105	ENSORLP00000031669	ENSORLP00000030602	BZIP domain-containing protein.	cAMP responsive element binding protein 1b.	0.543
ENSORLP00000031669	LOC101174084	ENSORLP00000031669	ENSORLP00000045957	BZIP domain-containing protein.	KID domain-containing protein.	0.902
ENSORLP00000033268	ENSORLP00000045758	ENSORLP00000033268	ENSORLP00000045758	Ins145_P3_rec domain-containing protein.	Uncharacterized protein.	0.888
ENSORLP00000033268	Ryr3	ENSORLP00000033268	ENSORLP00000043664	Ins145_P3_rec domain-containing protein.	B30.2/SPRY domain-containing protein.	0.933
ENSORLP00000033268	ryr1	ENSORLP00000033268	ENSORLP00000001304	Ins145_P3_rec domain-containing protein.	Ryanodine receptor 1b (skeletal).	0.747
ENSORLP00000033307	LOC101161541	ENSORLP00000033307	ENSORLP00000043809	Uncharacterized protein.	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family.	0.978
ENSORLP00000033307	LOC101166715	ENSORLP00000033307	ENSORLP00000034183	Uncharacterized protein.	Uncharacterized protein; Belongs to the potassium channel family.	0.978
ENSORLP00000041349	ENSORLP00000045758	ENSORLP00000041349	ENSORLP00000045758	Ins145_P3_rec domain-containing protein.	Uncharacterized protein.	0.795
ENSORLP00000041349	Ryr3	ENSORLP00000041349	ENSORLP00000043664	Ins145_P3_rec domain-containing protein.	B30.2/SPRY domain-containing protein.	0.929
ENSORLP00000041349	ryr1	ENSORLP00000041349	ENSORLP00000001304	Ins145_P3_rec domain-containing protein.	Ryanodine receptor 1b (skeletal).	0.920
ENSORLP00000045758	ENSORLP00000033268	ENSORLP00000045758	ENSORLP00000033268	Uncharacterized protein.	Ins145_P3_rec domain-containing protein.	0.888
ENSORLP00000045758	ENSORLP00000041349	ENSORLP00000045758	ENSORLP00000041349	Uncharacterized protein.	Ins145_P3_rec domain-containing protein.	0.795
ENSORLP00000045758	H2MVY7_ORYLA	ENSORLP00000045758	ENSORLP00000022994	Uncharacterized protein.	Uncharacterized protein.	0.920
ENSORLP00000045758	Ryr3	ENSORLP00000045758	ENSORLP00000043664	Uncharacterized protein.	B30.2/SPRY domain-containing protein.	0.900
H2MD80_ORYLA	HCN2	ENSORLP00000016520	ENSORLP00000005409	Hyperpolarization activated cyclic nucleotide-gated potassium channel 4.	Hyperpolarization activated cyclic nucleotide-gated potassium channel 2b.	0.585
H2MD80_ORYLA	LOC101157708	ENSORLP00000016520	ENSORLP00000033283	Hyperpolarization activated cyclic nucleotide-gated potassium channel 4.	Hyperpolarization activated cyclic nucleotide-gated potassium channel 3.	0.567
H2MD80_ORYLA	LOC101158796	ENSORLP00000016520	ENSORLP00000038302	Hyperpolarization activated cyclic nucleotide-gated potassium channel 4.	Cyclic nucleotide-binding domain-containing protein.	0.581
H2MD80_ORYLA	LOC101159259	ENSORLP00000016520	ENSORLP00000019258	Hyperpolarization activated cyclic nucleotide-gated potassium channel 4.	Cyclic nucleotide-binding domain-containing protein.	0.550