(41 nodes) Negative regulation of angiogenesis network (Oryzias latipes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ccn6	Cellular communication network factor 6. (320 aa)
	emilin1	Uncharacterized protein. (1116 aa)
	LOC101166566	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	sars1	Seryl-tRNA synthetase. (516 aa)
	LOC101155037	Transforming growth factor beta; Belongs to the TGF-beta family. (420 aa)
	LOC101171145	Sprouty RTK signaling antagonist 2. (342 aa)
	tbc1d31	TBC1 domain family, member 31. (1067 aa)
	hgs	Hepatocyte growth factor-regulated tyrosine kinase substrate. (766 aa)
	adgrb3	Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1541 aa)
	LOC101172593	Tumor necrosis factor a (TNF superfamily, member 2). (279 aa)
	serpine1	SERPIN domain-containing protein; Belongs to the serpin family. (447 aa)
	thbs2	Thrombospondin 2a. (1203 aa)
	cnmd	Chondromodulin-I. (316 aa)
	ism1	Isthmin 1. (453 aa)
	rgcc	Regulator of cell cycle. (154 aa)
	APOH	Uncharacterized protein. (364 aa)
	APOH-2	Apolipoprotein H. (362 aa)
	s1pr1	Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	H2MJT0_ORYLA	Uncharacterized protein. (589 aa)
	LOC101160037	Elastin microfibril interfacer 1a. (1027 aa)
	VASH1	Vasohibin 1. (335 aa)
	thbs1	Uncharacterized protein. (1172 aa)
	LOC100302438	Thrombospondin 1b. (1186 aa)
	krit1	KRIT1 ankyrin repeat containing. (740 aa)
	Nf1	Uncharacterized protein. (506 aa)
	adgrb1	Adhesion G protein-coupled receptor B1a; Belongs to the G-protein coupled receptor 2 family. (1587 aa)
	LOC101160423	Ephrin-A3a; Belongs to the ephrin family. (224 aa)
	vash2	Vasohibin 2. (371 aa)
	il-17a/f-1	Interleukin-17A/F-1. (152 aa)
	LOC101167660	Chondromodulin. (327 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (378 aa)
	LOC101172697	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1401 aa)
	adgrb2	Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1614 aa)
	tnmd	Tenomodulin. (307 aa)
	yjefn3	YjeF N-terminal domain containing 3. (247 aa)
	LOC101171679	Adhesion G protein-coupled receptor B1b; Belongs to the G-protein coupled receptor 2 family. (1522 aa)
	LOC101159737	Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (269 aa)
	il-17a/f-3	Interleukin-17A/F-3. (157 aa)
	efna3	Ephrin-A3b; Belongs to the ephrin family. (221 aa)
	LOC101167186	Methyl CpG binding protein 2. (1004 aa)
	rock1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1364 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2MJT0_ORYLA	Nf1	ENSORLP00000018929	ENSORLP00000026133	Uncharacterized protein.	Uncharacterized protein.	0.943
LOC100302438	LOC101155037	ENSORLP00000022311	ENSORLP00000002897	Thrombospondin 1b.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.455
LOC100302438	thbs1	ENSORLP00000022311	ENSORLP00000021092	Thrombospondin 1b.	Uncharacterized protein.	0.900
LOC101155037	LOC100302438	ENSORLP00000002897	ENSORLP00000022311	Transforming growth factor beta; Belongs to the TGF-beta family.	Thrombospondin 1b.	0.455
LOC101155037	LOC101172593	ENSORLP00000002897	ENSORLP00000013121	Transforming growth factor beta; Belongs to the TGF-beta family.	Tumor necrosis factor a (TNF superfamily, member 2).	0.405
LOC101155037	serpine1	ENSORLP00000002897	ENSORLP00000013133	Transforming growth factor beta; Belongs to the TGF-beta family.	SERPIN domain-containing protein; Belongs to the serpin family.	0.461
LOC101155037	thbs1	ENSORLP00000002897	ENSORLP00000021092	Transforming growth factor beta; Belongs to the TGF-beta family.	Uncharacterized protein.	0.455
LOC101155037	thbs2	ENSORLP00000002897	ENSORLP00000013451	Transforming growth factor beta; Belongs to the TGF-beta family.	Thrombospondin 2a.	0.455
LOC101159737	LOC101172593	ENSORLP00000040434	ENSORLP00000013121	Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family.	Tumor necrosis factor a (TNF superfamily, member 2).	0.678
LOC101159737	il-17a/f-3	ENSORLP00000040434	ENSORLP00000040657	Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family.	Interleukin-17A/F-3.	0.449
LOC101171145	hgs	ENSORLP00000005779	ENSORLP00000008971	Sprouty RTK signaling antagonist 2.	Hepatocyte growth factor-regulated tyrosine kinase substrate.	0.611
LOC101172593	LOC101155037	ENSORLP00000013121	ENSORLP00000002897	Tumor necrosis factor a (TNF superfamily, member 2).	Transforming growth factor beta; Belongs to the TGF-beta family.	0.405
LOC101172593	LOC101159737	ENSORLP00000013121	ENSORLP00000040434	Tumor necrosis factor a (TNF superfamily, member 2).	Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family.	0.678
LOC101172593	serpine1	ENSORLP00000013121	ENSORLP00000013133	Tumor necrosis factor a (TNF superfamily, member 2).	SERPIN domain-containing protein; Belongs to the serpin family.	0.405
LOC101172697	rock1	ENSORLP00000036846	ENSORLP00000045337	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.907
Nf1	H2MJT0_ORYLA	ENSORLP00000026133	ENSORLP00000018929	Uncharacterized protein.	Uncharacterized protein.	0.943
hgs	LOC101171145	ENSORLP00000008971	ENSORLP00000005779	Hepatocyte growth factor-regulated tyrosine kinase substrate.	Sprouty RTK signaling antagonist 2.	0.611
il-17a/f-1	il-17a/f-3	ENSORLP00000028491	ENSORLP00000040657	Interleukin-17A/F-1.	Interleukin-17A/F-3.	0.913
il-17a/f-3	LOC101159737	ENSORLP00000040657	ENSORLP00000040434	Interleukin-17A/F-3.	Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family.	0.449
il-17a/f-3	il-17a/f-1	ENSORLP00000040657	ENSORLP00000028491	Interleukin-17A/F-3.	Interleukin-17A/F-1.	0.913