(36 nodes) Wnt-protein binding network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101166122	Adenomatosis polyposis coli down-regulated 1-like. (511 aa)
	Fzd8	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (573 aa)
	Fzd2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (547 aa)
	LOC101157691	Sizzled. (283 aa)
	cthrc1	Collagen triple helix repeat containing 1b. (229 aa)
	H2L9W7_ORYLA	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
	ryk	Receptor like tyrosine kinase. (642 aa)
	porcn	Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (481 aa)
	ror2	Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (938 aa)
	lrp5	Low density lipoprotein receptor-related protein 5. (1634 aa)
	ENSORLP00000026165	Kringle domain-containing protein. (94 aa)
	LOC101155505	TraB domain containing 2B. (529 aa)
	LOC101175347	Uncharacterized protein. (1552 aa)
	APCDD1	APC down-regulated 1. (628 aa)
	LOC110013320	Uncharacterized protein. (213 aa)
	wls	Wnt ligand secretion mediator. (554 aa)
	lrp6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1623 aa)
	sfrp1	Uncharacterized protein. (306 aa)
	FZD3	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (755 aa)
	fzd6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (682 aa)
	LOC101156794	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
	LOC101155172	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (450 aa)
	trabd2a	TraB domain containing 2A. (511 aa)
	LOC101171428	FZ domain-containing protein. (337 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (529 aa)
	H2M3J6_ORYLA	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
	ror1	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (954 aa)
	H2LYZ3_ORYLA	Uncharacterized protein. (267 aa)
	sfrp2	Secreted frizzled-related protein 2. (290 aa)
	sfrp5	Secreted frizzled-related protein 5. (319 aa)
	fzd3	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family. (695 aa)
	H2MKU6_ORYLA	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa)
	LOC101168409	Frizzled related protein. (314 aa)
	fzd10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (578 aa)
	fjx1	Four-jointed box kinase 1. (422 aa)
	fzd9	Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FZD3	LOC101171428	ENSORLP00000041426	ENSORLP00000013980	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	FZ domain-containing protein.	0.716
FZD3	fzd10	ENSORLP00000041426	ENSORLP00000017110	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	0.403
FZD3	fzd4	ENSORLP00000041426	ENSORLP00000013516	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.548
FZD3	fzd9	ENSORLP00000041426	ENSORLP00000014516	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family.	0.421
FZD3	lrp5	ENSORLP00000041426	ENSORLP00000026836	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Low density lipoprotein receptor-related protein 5.	0.906
FZD3	lrp6	ENSORLP00000041426	ENSORLP00000040318	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.906
FZD3	ror1	ENSORLP00000041426	ENSORLP00000012786	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.761
FZD3	ror2	ENSORLP00000041426	ENSORLP00000031374	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.761
FZD3	ryk	ENSORLP00000041426	ENSORLP00000001259	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor like tyrosine kinase.	0.922
FZD3	sfrp1	ENSORLP00000041426	ENSORLP00000040398	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.737
FZD3	sfrp2	ENSORLP00000041426	ENSORLP00000010461	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 2.	0.716
FZD3	sfrp5	ENSORLP00000041426	ENSORLP00000009550	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 5.	0.737
Fzd2	LOC101171428	ENSORLP00000005263	ENSORLP00000013980	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	FZ domain-containing protein.	0.682
Fzd2	fzd4	ENSORLP00000005263	ENSORLP00000013516	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.439
Fzd2	lrp5	ENSORLP00000005263	ENSORLP00000026836	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Low density lipoprotein receptor-related protein 5.	0.918
Fzd2	lrp6	ENSORLP00000005263	ENSORLP00000040318	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.923
Fzd2	ror1	ENSORLP00000005263	ENSORLP00000012786	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.805
Fzd2	ror2	ENSORLP00000005263	ENSORLP00000031374	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.807
Fzd2	ryk	ENSORLP00000005263	ENSORLP00000001259	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor like tyrosine kinase.	0.935
Fzd2	sfrp1	ENSORLP00000005263	ENSORLP00000040398	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.736