(70 nodes) T cell differentiation network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	card11	Caspase recruitment domain family, member 11. (1146 aa)
	batf	Basic leucine zipper transcription factor, ATF-like. (121 aa)
	H2ME78_ORYLA	SEFIR domain-containing protein. (115 aa)
	srf	Serum response factor b. (611 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (387 aa)
	rag2	Recombination activating gene 2. (532 aa)
	rag1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1090 aa)
	gpr18	G protein-coupled receptor 18. (337 aa)
	LOC101168082	G protein-coupled receptor 183a; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	H2M3J6_ORYLA	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
	LOC101170530	Ring finger and CCCH-type domains 2. (1143 aa)
	tsc1	TSC complex subunit 1b. (1198 aa)
	LOC101157986	Sp3b transcription factor. (614 aa)
	Traf3ip2	SEFIR domain-containing protein. (116 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
	cd83	Ig-like domain-containing protein. (223 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	zbtb1	Zinc finger and BTB domain containing 1. (684 aa)
	LOC101158138	Ring finger and CCCH-type domains 1b. (1116 aa)
	SP3	Sp3a transcription factor. (668 aa)
	H2MU64_ORYLA	Chemokine (C-C motif) receptor 6b; Belongs to the G-protein coupled receptor 1 family. (413 aa)
	LOC101173752	IGv domain-containing protein. (224 aa)
	abl2	Tyrosine-protein kinase. (1185 aa)
	prr7	Proline rich 7, synaptic. (253 aa)
	LOC101170171	Zeta chain of T cell receptor associated protein kinase 70. (668 aa)
	LOC101168038	Protein kinase domain-containing protein. (509 aa)
	LOC101167831	Si:ch211-184m13.4; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	LOC101168285	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (415 aa)
	ENSORLP00000030535	Fibronectin type-III domain-containing protein. (383 aa)
	LOC101162133	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (471 aa)
	ENSORLP00000031311	Uncharacterized protein. (248 aa)
	LOC105358811	MADS-box domain-containing protein. (552 aa)
	tbx21	T-box transcription factor 21. (619 aa)
	LOC100125537	Uncharacterized protein. (246 aa)
	ENSORLP00000033333	Proteasome subunit beta. (293 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1343 aa)
	LOC100125524	Forkhead box N1. (574 aa)
	syk	Tyrosine-protein kinase. (624 aa)
	lig4	DNA ligase. (912 aa)
	tcf7	Transcription factor 7. (536 aa)
	NKX2-3	NK2 homeobox 3. (351 aa)
	ENSORLP00000038465	Uncharacterized protein. (174 aa)
	themis2	Thymocyte selection associated family member 2. (728 aa)
	lepr	Leptin recepter. (1074 aa)
	ccr6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (376 aa)
	LOC101162039	KRAP_IP3R_bind domain-containing protein. (667 aa)
	abl1	Tyrosine-protein kinase. (1106 aa)
	LOC101173653	Fibronectin type-III domain-containing protein. (588 aa)
	fadd	Uncharacterized protein. (192 aa)
	rabl3	RAB, member of RAS oncogene family-like 3. (243 aa)
	LOC101161323	Ig_4 domain-containing protein. (166 aa)
	jak1	Tyrosine-protein kinase. (1170 aa)
	LOC101168078	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily. (481 aa)
	LOC101162072	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (478 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (590 aa)
	nkx2-3	NK2 homeobox 3. (341 aa)
	lef1	Lymphoid enhancer-binding factor 1. (379 aa)
	H2LR21_ORYLA	Uncharacterized protein. (172 aa)
	agtpbp1	ATP/GTP binding protein 1. (1237 aa)
	Fzd8	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (573 aa)
	ptger4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (443 aa)
	LOC101164045	SEFIR domain-containing protein. (443 aa)
	tmem98	Transmembrane protein 98. (224 aa)
	H2L9W7_ORYLA	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
	armc5	Armadillo repeat containing 5. (1210 aa)
	LOC101157631	Transforming growth factor beta; Belongs to the TGF-beta family. (444 aa)
	sash3	SAM and SH3 domain containing 3. (391 aa)
	LOC101163430	Interferon regulatory factor. (293 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1023 aa)
	H2L4B7_ORYLA	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (737 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000030535	ENSORLP00000038465	ENSORLP00000030535	ENSORLP00000038465	Fibronectin type-III domain-containing protein.	Uncharacterized protein.	0.430
ENSORLP00000030535	H2LR21_ORYLA	ENSORLP00000030535	ENSORLP00000008518	Fibronectin type-III domain-containing protein.	Uncharacterized protein.	0.430
ENSORLP00000030535	LOC100125537	ENSORLP00000030535	ENSORLP00000032993	Fibronectin type-III domain-containing protein.	Uncharacterized protein.	0.589
ENSORLP00000030535	LOC101161323	ENSORLP00000030535	ENSORLP00000043696	Fibronectin type-III domain-containing protein.	Ig_4 domain-containing protein.	0.743
ENSORLP00000030535	jak1	ENSORLP00000030535	ENSORLP00000044142	Fibronectin type-III domain-containing protein.	Tyrosine-protein kinase.	0.695
ENSORLP00000030535	ptprc	ENSORLP00000030535	ENSORLP00000035490	Fibronectin type-III domain-containing protein.	Protein tyrosine phosphatase receptor type C.	0.668
ENSORLP00000030535	rag1	ENSORLP00000030535	ENSORLP00000014992	Fibronectin type-III domain-containing protein.	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]	0.471
ENSORLP00000030535	tbx21	ENSORLP00000030535	ENSORLP00000032374	Fibronectin type-III domain-containing protein.	T-box transcription factor 21.	0.408
ENSORLP00000031311	H2L4B7_ORYLA	ENSORLP00000031311	ENSORLP00000000606	Uncharacterized protein.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.850
ENSORLP00000031311	Mtor	ENSORLP00000031311	ENSORLP00000000608	Uncharacterized protein.	Serine/threonine-protein kinase TOR.	0.850
ENSORLP00000031311	rabl3	ENSORLP00000031311	ENSORLP00000043466	Uncharacterized protein.	RAB, member of RAS oncogene family-like 3.	0.554
ENSORLP00000031311	stk11	ENSORLP00000031311	ENSORLP00000019300	Uncharacterized protein.	Serine/threonine kinase 11; Belongs to the protein kinase superfamily.	0.549
ENSORLP00000031311	tsc1	ENSORLP00000031311	ENSORLP00000018027	Uncharacterized protein.	TSC complex subunit 1b.	0.545
ENSORLP00000038465	ENSORLP00000030535	ENSORLP00000038465	ENSORLP00000030535	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.430
ENSORLP00000038465	H2LR21_ORYLA	ENSORLP00000038465	ENSORLP00000008518	Uncharacterized protein.	Uncharacterized protein.	0.540
ENSORLP00000038465	LOC100125537	ENSORLP00000038465	ENSORLP00000032993	Uncharacterized protein.	Uncharacterized protein.	0.884
ENSORLP00000038465	LOC101161323	ENSORLP00000038465	ENSORLP00000043696	Uncharacterized protein.	Ig_4 domain-containing protein.	0.995
ENSORLP00000038465	LOC101170171	ENSORLP00000038465	ENSORLP00000028913	Uncharacterized protein.	Zeta chain of T cell receptor associated protein kinase 70.	0.862
ENSORLP00000038465	ptprc	ENSORLP00000038465	ENSORLP00000035490	Uncharacterized protein.	Protein tyrosine phosphatase receptor type C.	0.664
ENSORLP00000038465	syk	ENSORLP00000038465	ENSORLP00000036465	Uncharacterized protein.	Tyrosine-protein kinase.	0.862