(20 nodes) DNA damage response, signal transduction by p53 class mediator network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	acer2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (277 aa)
	LOC101168864	P53-induced death domain protein 1. (1004 aa)
	LOC101175405	Transcription factor AP-4 (activating enhancer binding protein 4). (330 aa)
	foxm1	Fork-head domain-containing protein. (674 aa)
	usp10	Ubiquitin carboxyl-terminal hydrolase. (882 aa)
	chek2	Checkpoint kinase 2. (526 aa)
	brca2	BRCA2 DNA repair associated. (3161 aa)
	ppm1d	Protein phosphatase, Mg2+/Mn2+ dependent, 1Da. (544 aa)
	LOC101165012	Ribosomal protein S6 kinase. (734 aa)
	atrx	ATRX chromatin remodeler. (2095 aa)
	LOC101164618	CASP2 and RIPK1 domain containing adaptor with death domain. (203 aa)
	myo6	Myosin VIa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1203 aa)
	TFAP4	Transcription factor AP-4 (activating enhancer binding protein 4). (332 aa)
	LOC101175525	Myosin VIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1253 aa)
	LOC101158988	E2F transcription factor 7. (795 aa)
	casp2	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (501 aa)
	LOC101156348	Protein phosphatase, Mg2+/Mn2+ dependent, 1Db. (566 aa)
	LOC101171430	Uncharacterized protein. (1871 aa)
	batf	Basic leucine zipper transcription factor, ATF-like. (121 aa)
	hdx	Ribosomal protein S6 kinase. (783 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101156348	chek2	ENSORLP00000012568	ENSORLP00000032936	Protein phosphatase, Mg2+/Mn2+ dependent, 1Db.	Checkpoint kinase 2.	0.578
LOC101156348	ppm1d	ENSORLP00000012568	ENSORLP00000029022	Protein phosphatase, Mg2+/Mn2+ dependent, 1Db.	Protein phosphatase, Mg2+/Mn2+ dependent, 1Da.	0.903
LOC101158988	foxm1	ENSORLP00000015398	ENSORLP00000030204	E2F transcription factor 7.	Fork-head domain-containing protein.	0.556
LOC101164618	LOC101168864	ENSORLP00000023990	ENSORLP00000007907	CASP2 and RIPK1 domain containing adaptor with death domain.	P53-induced death domain protein 1.	0.983
LOC101164618	casp2	ENSORLP00000023990	ENSORLP00000015114	CASP2 and RIPK1 domain containing adaptor with death domain.	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.961
LOC101168864	LOC101164618	ENSORLP00000007907	ENSORLP00000023990	P53-induced death domain protein 1.	CASP2 and RIPK1 domain containing adaptor with death domain.	0.983
LOC101168864	casp2	ENSORLP00000007907	ENSORLP00000015114	P53-induced death domain protein 1.	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.978
LOC101171430	brca2	ENSORLP00000011523	ENSORLP00000039367	Uncharacterized protein.	BRCA2 DNA repair associated.	0.402
atrx	brca2	ENSORLP00000007639	ENSORLP00000039367	ATRX chromatin remodeler.	BRCA2 DNA repair associated.	0.402
brca2	LOC101171430	ENSORLP00000039367	ENSORLP00000011523	BRCA2 DNA repair associated.	Uncharacterized protein.	0.402
brca2	atrx	ENSORLP00000039367	ENSORLP00000007639	BRCA2 DNA repair associated.	ATRX chromatin remodeler.	0.402
brca2	chek2	ENSORLP00000039367	ENSORLP00000032936	BRCA2 DNA repair associated.	Checkpoint kinase 2.	0.747
casp2	LOC101164618	ENSORLP00000015114	ENSORLP00000023990	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	CASP2 and RIPK1 domain containing adaptor with death domain.	0.961
casp2	LOC101168864	ENSORLP00000015114	ENSORLP00000007907	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	P53-induced death domain protein 1.	0.978
chek2	LOC101156348	ENSORLP00000032936	ENSORLP00000012568	Checkpoint kinase 2.	Protein phosphatase, Mg2+/Mn2+ dependent, 1Db.	0.578
chek2	brca2	ENSORLP00000032936	ENSORLP00000039367	Checkpoint kinase 2.	BRCA2 DNA repair associated.	0.747
chek2	ppm1d	ENSORLP00000032936	ENSORLP00000029022	Checkpoint kinase 2.	Protein phosphatase, Mg2+/Mn2+ dependent, 1Da.	0.578
foxm1	LOC101158988	ENSORLP00000030204	ENSORLP00000015398	Fork-head domain-containing protein.	E2F transcription factor 7.	0.556
ppm1d	LOC101156348	ENSORLP00000029022	ENSORLP00000012568	Protein phosphatase, Mg2+/Mn2+ dependent, 1Da.	Protein phosphatase, Mg2+/Mn2+ dependent, 1Db.	0.903
ppm1d	chek2	ENSORLP00000029022	ENSORLP00000032936	Protein phosphatase, Mg2+/Mn2+ dependent, 1Da.	Checkpoint kinase 2.	0.578