(135 nodes) Negative regulation of cell migration network (Oryzias latipes)

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101163409	SLIT-ROBO Rho GTPase activating protein 1a. (1024 aa)
	emilin1	Uncharacterized protein. (1116 aa)
	LOC101159216	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (527 aa)
	LOC101166566	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	LOC101157631	Transforming growth factor beta; Belongs to the TGF-beta family. (444 aa)
	H2L7K0_ORYLA	Thyroglobulin type-1 domain-containing protein. (232 aa)
	map2k5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (445 aa)
	LOC101157923	Insulin-like growth factor binding protein 5a. (253 aa)
	LOC101170271	Nerve growth factor receptor a (TNFR superfamily, member 16). (389 aa)
	ripor3	RIPOR family member 3. (787 aa)
	LOC101163907	Uncharacterized protein. (386 aa)
	ptger4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (443 aa)
	H2LLT1_ORYLA	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	RAP2B	RAP2B, member of RAS oncogene family. (186 aa)
	nexmif	Neurite extension and migration factor b. (1490 aa)
	LOC101168024	Ig-like domain-containing protein. (271 aa)
	LOC111946296	Ig-like domain-containing protein. (291 aa)
	gtpbp4	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa)
	LOC101166301	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (321 aa)
	H2LPQ5_ORYLA	G_PROTEIN_RECEP_F1_2 domain-containing protein. (209 aa)
	tbxa2r	Thromboxane A2 receptor. (352 aa)
	AIF1	Allograft inflammatory factor 1. (154 aa)
	LOC101155575	Uncharacterized protein. (1806 aa)
	sfrp2	Secreted frizzled-related protein 2. (290 aa)
	LOC101162072	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (478 aa)
	gna12	G protein subunit alpha 12. (385 aa)
	arid2	AT rich interactive domain 2 (ARID, RFX-like). (1631 aa)
	LOC101167454	Abhydrolase domain containing 6b. (340 aa)
	LOC101172593	Tumor necrosis factor a (TNF superfamily, member 2). (279 aa)
	serpine1	SERPIN domain-containing protein; Belongs to the serpin family. (447 aa)
	LOC101172976	SIN3-HDAC complex associated factor. (274 aa)
	WDR63	WD repeat domain 63. (857 aa)
	dag1	Dystroglycan 1. (868 aa)
	LOC101171428	FZ domain-containing protein. (337 aa)
	gpr18	G protein-coupled receptor 18. (337 aa)
	inppl1	Inositol polyphosphate phosphatase-like 1a. (1249 aa)
	emilin2	Elastin microfibril interfacer 2b. (977 aa)
	flcn	Folliculin. (558 aa)
	mmp28	Matrix metallopeptidase 28. (485 aa)
	LOC101161311	Protein kinase C binding protein 1, like. (1143 aa)
	dusp10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (472 aa)
	cldn19	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
	scai	Suppressor of cancer cell invasion. (566 aa)
	LOC101173369	Junction plakoglobin a. (733 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	ripor2	RHO family interacting cell polarization regulator 2. (1127 aa)
	rgcc	Regulator of cell cycle. (154 aa)
	LOC111948766	Uncharacterized protein. (294 aa)
	bmerb1	BMERB domain containing 1. (198 aa)
	APOH	Uncharacterized protein. (364 aa)
	APOH-2	Apolipoprotein H. (362 aa)
	LOC101161673	Apolipoprotein Eb. (265 aa)
	LOC101168567	RAB guanine nucleotide exchange factor (GEF) 1. (495 aa)
	podn	Podocan. (614 aa)
	adipor1	Adiponectin receptor 1a. (371 aa)
	H2MJT0_ORYLA	Uncharacterized protein. (589 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (198 aa)
	dcn	Decorin; May affect the rate of fibrils formation. (367 aa)
	bmp10	Bone morphogenetic protein 10. (488 aa)
	LOC101166419	C2 NT-type domain-containing protein. (369 aa)
	magi2	Membrane associated guanylate kinase, WW and PDZ domain containing 2a. (1331 aa)
	ADORA1	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (346 aa)
	LOC101160037	Elastin microfibril interfacer 1a. (1027 aa)
	tnn	Tenascin N. (834 aa)
	VASH1	Vasohibin 1. (335 aa)
	bcl2	BCL2 apoptosis regulator b. (202 aa)
	H2MR15_ORYLA	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (514 aa)
	IGFBP3	Insulin like growth factor binding protein 3. (292 aa)
	srgap1	SLIT-ROBO Rho GTPase activating protein 1b. (1173 aa)
	LOC101159749	Guanine nucleotide binding protein (G protein), alpha 13b. (359 aa)
	c5	Uncharacterized protein. (1211 aa)
	nfe2l2	Nuclear factor, erythroid 2-like 2a. (605 aa)
	LOC101167075	Apolipoprotein Da, duplicate 1; Belongs to the calycin superfamily. Lipocalin family. (186 aa)
	llgl2	LLGL scribble cell polarity complex component 2. (1024 aa)
	LOC101162018	Uncharacterized protein. (360 aa)
	tnfaip6	Tumor necrosis factor, alpha-induced protein 6. (256 aa)
	abhd6	AB hydrolase-1 domain-containing protein. (337 aa)
	nisch	Nischarin. (1429 aa)
	H2MZU7_ORYLA	Uncharacterized protein. (279 aa)
	limch1	LIM and calponin homology domains 1b. (1051 aa)
	ptprg	Carbonic anhydrase XVI b. (1050 aa)
	LOC101155569	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
	Nf1	Uncharacterized protein. (506 aa)
	LOC101174364	RAB guanine nucleotide exchange factor (GEF) 1, like. (501 aa)
	rap2c	RAP2C, member of RAS oncogene family. (183 aa)
	Cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (109 aa)
	srgap3	SLIT-ROBO Rho GTPase activating protein 3. (1101 aa)
	LOC110017569	SIN3-HDAC complex associated factor, like. (230 aa)
	LOC101162800	VPS9 domain-containing protein. (1038 aa)
	vash2	Vasohibin 2. (371 aa)
	churc1	Churchill domain containing 1. (158 aa)
	meox2	Mesenchyme homeobox 2a. (366 aa)
	LOC101167443	Si:ch211-191a24.4. (282 aa)
	fam102a	Family with sequence similarity 102 member Aa. (384 aa)
	LOC101160003	Mothers against decapentaplegic homolog. (464 aa)
	LOC101170718	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family. (232 aa)
	LOC101167532	Interleukin 19 like. (163 aa)
	LOC101162133	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (471 aa)
	PTPRM	Uncharacterized protein. (1041 aa)
	LOC101170232	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family. (195 aa)
	LOC101158188	Protein tyrosine phosphatase receptor type T. (1505 aa)
	MYOCD	Myocardin. (884 aa)
	LOC101161561	BMERB domain-containing protein. (177 aa)
	Cxcl13	SCY domain-containing protein. (91 aa)
	LOC105355769	EGF-like domain-containing protein. (520 aa)
	LOC101165913	EMI domain-containing protein. (800 aa)
	LOC101167197	Si:ch211-191a24.4. (360 aa)
	ushbp1	Usher syndrome 1C binding protein 1. (693 aa)
	LOC101174943	Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (2042 aa)
	LOC101166327	Si:dkey-175m17.7. (881 aa)
	LOC101173221	Membrane associated guanylate kinase, WW and PDZ domain containing 2b. (1528 aa)
	adipor2	Adiponectin receptor 2. (374 aa)
	LOC101165732	Peptidase S72 domain-containing protein. (901 aa)
	ptpn23	Protein tyrosine phosphatase, non-receptor type 23, a. (1885 aa)
	LOC101167714	Stanniocalcin 1. (287 aa)
	LOC101169804	Epithelial cell adhesion molecule. (386 aa)
	RAP2A	Uncharacterized protein. (183 aa)
	afdn	Afadin, adherens junction formation factor a. (1700 aa)
	fam102b	Family with sequence similarity 102 member Bb. (378 aa)
	CCN3	Cellular communication network factor 3. (366 aa)
	miip	Migration and invasion inhibitory protein. (377 aa)
	srgap2	SLIT-ROBO Rho GTPase activating protein 2. (1117 aa)
	ptprk	Protein tyrosine phosphatase receptor type K. (1517 aa)
	LOC101160890	Uncharacterized protein. (1572 aa)
	LOC101157715	Bone morphogenetic protein 10, like. (441 aa)
	LOC101155067	Insulin-like growth factor binding protein 5a. (266 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (291 aa)
	LOC101175623	Zgc:171844. (187 aa)
	ENSORLP00000042985	G_PROTEIN_RECEP_F1_2 domain-containing protein. (473 aa)
	LOC101163116	Neuregulin 3b. (763 aa)
	CARD10	Caspase recruitment domain family member 10. (1012 aa)
	LOC101162278	Chemokine (C-C motif) ligand 25b. (96 aa)
	LOC101175626	Uncharacterized protein. (372 aa)
	LOC101166399	Apolipoprotein Ea. (262 aa)
	LOC101167186	Methyl CpG binding protein 2. (1004 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIF1	LOC101172593	ENSORLP00000008655	ENSORLP00000013121	Allograft inflammatory factor 1.	Tumor necrosis factor a (TNF superfamily, member 2).	0.498
Cldn5	LOC101155569	ENSORLP00000026956	ENSORLP00000025334	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.712
Cldn5	LOC101165913	ENSORLP00000026956	ENSORLP00000034736	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	EMI domain-containing protein.	0.405
Cldn5	LOC101166566	ENSORLP00000026956	ENSORLP00000001336	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
Cldn5	cldn19	ENSORLP00000026956	ENSORLP00000015539	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.698
Cxcl13	LOC101162278	ENSORLP00000033122	ENSORLP00000044456	SCY domain-containing protein.	Chemokine (C-C motif) ligand 25b.	0.669
H2LLT1_ORYLA	LOC101159749	ENSORLP00000006996	ENSORLP00000021734	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide binding protein (G protein), alpha 13b.	0.650
H2LLT1_ORYLA	LOC101162018	ENSORLP00000006996	ENSORLP00000023490	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.650
H2LLT1_ORYLA	LOC101175626	ENSORLP00000006996	ENSORLP00000044498	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.650
H2LLT1_ORYLA	gna12	ENSORLP00000006996	ENSORLP00000011218	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family.	G protein subunit alpha 12.	0.650
H2MJT0_ORYLA	Nf1	ENSORLP00000018929	ENSORLP00000026133	Uncharacterized protein.	Uncharacterized protein.	0.943
H2MJT0_ORYLA	RAP2A	ENSORLP00000018929	ENSORLP00000038393	Uncharacterized protein.	Uncharacterized protein.	0.576
H2MJT0_ORYLA	RAP2B	ENSORLP00000018929	ENSORLP00000007391	Uncharacterized protein.	RAP2B, member of RAS oncogene family.	0.576
H2MJT0_ORYLA	rap2c	ENSORLP00000018929	ENSORLP00000026482	Uncharacterized protein.	RAP2C, member of RAS oncogene family.	0.576
H2MZU7_ORYLA	PTPRM	ENSORLP00000024616	ENSORLP00000031291	Uncharacterized protein.	Uncharacterized protein.	0.894
IGFBP3	LOC101155067	ENSORLP00000021459	ENSORLP00000041462	Insulin like growth factor binding protein 3.	Insulin-like growth factor binding protein 5a.	0.459
IGFBP3	LOC101157923	ENSORLP00000021459	ENSORLP00000002784	Insulin like growth factor binding protein 3.	Insulin-like growth factor binding protein 5a.	0.419
LOC101155067	IGFBP3	ENSORLP00000041462	ENSORLP00000021459	Insulin-like growth factor binding protein 5a.	Insulin like growth factor binding protein 3.	0.459
LOC101155569	Cldn5	ENSORLP00000025334	ENSORLP00000026956	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.712
LOC101155569	LOC101166566	ENSORLP00000025334	ENSORLP00000001336	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.694