(29 nodes) Intracellular steroid hormone receptor signaling pathway network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101171584	Uncharacterized protein; Belongs to the DEAD box helicase family. (630 aa)
	nr3c1	Glucocorticoid receptor GR1a. (793 aa)
	phb	Prohibitin. (299 aa)
	LOC100302444	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (790 aa)
	SRC	Tyrosine-protein kinase. (544 aa)
	LOC101173499	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (491 aa)
	LOC105356557	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (393 aa)
	ar-alpha	Uncharacterized protein. (687 aa)
	LOC100049233	Androgen receptor beta subtype. (744 aa)
	LOC101158507	DEAD-box helicase 17; Belongs to the DEAD box helicase family. (648 aa)
	LOC101160075	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family. (624 aa)
	LOC101165876	Ubiquitin protein ligase E3A. (814 aa)
	esr2	Uncharacterized protein. (574 aa)
	esr2-2	Uncharacterized protein. (541 aa)
	LOC105355612	Uncharacterized protein. (762 aa)
	rwdd1	RWD domain containing 1. (240 aa)
	trip4	Thyroid hormone receptor interactor 4. (638 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (894 aa)
	LOC101167464	Death-domain associated protein. (729 aa)
	pgr	Uncharacterized protein. (667 aa)
	LOC101169121	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta. (924 aa)
	LOC105356389	Uncharacterized protein. (1013 aa)
	LOC101167461	NK3 homeobox 1. (188 aa)
	LOC101164480	Tyrosine-protein kinase. (551 aa)
	ubr5	Ubiquitin protein ligase E3 component n-recognin 5. (2859 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (634 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1782 aa)
	tmf1	TATA element modulatory factor 1. (1146 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (631 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX5	LOC101160075	ENSORLP00000045748	ENSORLP00000018923	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family.	0.901
DDX5	esr1	ENSORLP00000045748	ENSORLP00000042539	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.541
DDX5	esr2	ENSORLP00000045748	ENSORLP00000022181	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.541
DDX5	esr2-2	ENSORLP00000045748	ENSORLP00000022556	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.541
LOC100049233	LOC100302444	ENSORLP00000011941	ENSORLP00000007570	Androgen receptor beta subtype.	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).	0.482
LOC100049233	LOC101164480	ENSORLP00000011941	ENSORLP00000036233	Androgen receptor beta subtype.	Tyrosine-protein kinase.	0.549
LOC100049233	LOC101167461	ENSORLP00000011941	ENSORLP00000035844	Androgen receptor beta subtype.	NK3 homeobox 1.	0.494
LOC100049233	LOC101167464	ENSORLP00000011941	ENSORLP00000033835	Androgen receptor beta subtype.	Death-domain associated protein.	0.441
LOC100049233	SRC	ENSORLP00000011941	ENSORLP00000008431	Androgen receptor beta subtype.	Tyrosine-protein kinase.	0.549
LOC100049233	ar-alpha	ENSORLP00000011941	ENSORLP00000010323	Androgen receptor beta subtype.	Uncharacterized protein.	0.908
LOC100049233	esr1	ENSORLP00000011941	ENSORLP00000042539	Androgen receptor beta subtype.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.647
LOC100049233	med1	ENSORLP00000011941	ENSORLP00000043584	Androgen receptor beta subtype.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.576
LOC100049233	nr3c1	ENSORLP00000011941	ENSORLP00000001939	Androgen receptor beta subtype.	Glucocorticoid receptor GR1a.	0.482
LOC100049233	pgr	ENSORLP00000011941	ENSORLP00000034899	Androgen receptor beta subtype.	Uncharacterized protein.	0.615
LOC100302444	LOC100049233	ENSORLP00000007570	ENSORLP00000011941	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).	Androgen receptor beta subtype.	0.482
LOC100302444	LOC101167464	ENSORLP00000007570	ENSORLP00000033835	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).	Death-domain associated protein.	0.478
LOC100302444	ar-alpha	ENSORLP00000007570	ENSORLP00000010323	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).	Uncharacterized protein.	0.511
LOC100302444	med1	ENSORLP00000007570	ENSORLP00000043584	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.623
LOC100302444	nr3c1	ENSORLP00000007570	ENSORLP00000001939	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).	Glucocorticoid receptor GR1a.	0.903
LOC100302444	pgr	ENSORLP00000007570	ENSORLP00000034899	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).	Uncharacterized protein.	0.611