STRINGSTRING
trim33 trim33 yap1 yap1 sh2b3 sh2b3 etnppl etnppl phykpl phykpl LOC101175434 LOC101175434 rps24 rps24 H2LSI7_ORYLA H2LSI7_ORYLA ncoa2 ncoa2 PRKCB PRKCB LOC101159746 LOC101159746 chrd chrd LOC101172340 LOC101172340 LOC100125511 LOC100125511 ism1 ism1 lclat1 lclat1 PRKCA PRKCA H2MFW7_ORYLA H2MFW7_ORYLA ccdc134 ccdc134 slc40a1 slc40a1 LOC101170140 LOC101170140 tbx20 tbx20 cftr cftr myct1 myct1 LOC101161464 LOC101161464 tll1 tll1 hhex hhex hdac9 hdac9 ENSORLP00000033990 ENSORLP00000033990 LOC100049501 LOC100049501 LOC101164921 LOC101164921 atf4 atf4 LOC101174785 LOC101174785 TGFBR2 TGFBR2 LOC101174459 LOC101174459 lmo2 lmo2 med1 med1 gata-1 gata-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
trim33Tripartite motif containing 33. (1180 aa)
yap1Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. (440 aa)
sh2b3SH2B adaptor protein 3. (724 aa)
etnpplEthanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (488 aa)
phykpl5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (475 aa)
LOC101175434Nuclear receptor coactivator. (1496 aa)
rps2440S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family. (132 aa)
H2LSI7_ORYLABmi1 polycomb ring finger oncogene 1a. (332 aa)
ncoa2Nuclear receptor coactivator. (1498 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
LOC101159746Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
chrdChordin; Belongs to the chordin family. (946 aa)
LOC101172340Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family. (311 aa)
LOC100125511Metalloendopeptidase. (970 aa)
ism1Isthmin 1. (453 aa)
lclat1Lysocardiolipin acyltransferase 1. (385 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (709 aa)
H2MFW7_ORYLABHLH domain-containing protein. (113 aa)
ccdc134Si:dkey-167k11.5. (229 aa)
slc40a1Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (562 aa)
LOC101170140Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (392 aa)
tbx20T-box transcription factor 20. (439 aa)
cftrCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1502 aa)
myct1Myc target 1a. (196 aa)
LOC101161464Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
tll1Metalloendopeptidase. (1023 aa)
hhexHomeobox domain-containing protein. (469 aa)
hdac9Histone deacetylase 9b. (668 aa)
ENSORLP00000033990NOP10 ribonucleoprotein homolog (yeast). (64 aa)
LOC1000495015-aminolevulinate synthase. (591 aa)
LOC101164921Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
atf4BZIP domain-containing protein. (438 aa)
LOC101174785TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (587 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
LOC101174459T-cell acute lymphocytic leukemia 1. (394 aa)
lmo2LIM domain only 2 (rhombotin-like 1). (160 aa)
med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1782 aa)
gata-1Hematopietic transcription factor GATA-1. (417 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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