(94 nodes) Segmentation network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	axin1	Axin 1. (854 aa)
	tdrd1	Tudor domain-containing protein 1; Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of corr [...] (1141 aa)
	LOC101161131	Lysine (K)-specific demethylase 6A, like. (1465 aa)
	SMAD4	Mothers against decapentaplegic homolog. (510 aa)
	LOC101162949	Iroquois homeobox 1a. (500 aa)
	LOC101165094	Cordon-bleu WH2 repeat protein. (1444 aa)
	dctn2	Dynactin 2 (p50). (404 aa)
	LOC101167529	RAP1A, member of RAS oncogene family b. (185 aa)
	TBX6	T-box transcription factor 6. (242 aa)
	LOC101172518	Dickkopf WNT signaling pathway inhibitor 1a. (244 aa)
	lef1	Lymphoid enhancer-binding factor 1. (379 aa)
	scube2	Signal peptide, CUB domain, EGF-like 2. (1020 aa)
	LOC101172864	Uncharacterized protein. (255 aa)
	LOC101171257	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
	LOC101161576	RNA binding motif protein 24b. (237 aa)
	sfrp2	Secreted frizzled-related protein 2. (290 aa)
	naa50	N(alpha)-acetyltransferase 50, NatE catalytic subunit. (169 aa)
	chrd	Chordin; Belongs to the chordin family. (946 aa)
	LOC101170217	Abl-interactor 1b. (496 aa)
	LOC101164979	Transcription activation suppressor b. (1819 aa)
	hes7	BHLH domain-containing protein. (268 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
	LOC100049520	POU domain protein. (469 aa)
	LOC101171428	FZ domain-containing protein. (337 aa)
	rbm24	RNA binding motif protein 24a. (232 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (765 aa)
	ccdc80	Coiled-coil domain containing 80. (840 aa)
	H2ME95_ORYLA	Lysine (K)-specific demethylase 6A. (806 aa)
	irx3	Iroquois homeobox 3a. (423 aa)
	efhc2	EF-hand domain (C-terminal) containing 2. (734 aa)
	me-t	Me-Tam. (419 aa)
	LOC101155782	Iroquois homeobox 1b. (452 aa)
	rfng	Beta-1,3-N-acetylglucosaminyltransferase. (376 aa)
	cyp26a1	Cytochrome P450 26A1; Belongs to the cytochrome P450 family. (488 aa)
	LOC101162828	Mesoderm posterior ba. (262 aa)
	H2MIJ3_ORYLA	Uncharacterized protein. (781 aa)
	cactin	Cactin. (847 aa)
	cdh2	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (908 aa)
	LOC101158262	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (921 aa)
	notch1	Notch receptor 1b. (2507 aa)
	pofut1	Uncharacterized protein. (395 aa)
	LOC101160197	E1A binding protein p300 a. (2781 aa)
	VANGL2	Vang-like protein. (525 aa)
	LOC101162818	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
	LOC101164139	Protein tyrosine phosphatase receptor type Ub. (1397 aa)
	Atm	Uncharacterized protein. (147 aa)
	LOC101171501	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	supt6h	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1747 aa)
	naa35	N(alpha)-acetyltransferase 35, NatC auxiliary subunit. (753 aa)
	LOC101159406	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa; Belongs to the semaphorin family. (789 aa)
	ENSORLP00000027619	TAN domain-containing protein. (321 aa)
	LOC101161906	Transmembrane p24 trafficking protein 2. (207 aa)
	churc1	Churchill domain containing 1. (158 aa)
	meox2	Mesenchyme homeobox 2a. (366 aa)
	kif22	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (619 aa)
	LOC101173916	Mothers against decapentaplegic homolog. (538 aa)
	tdrd7	Tudor domain containing 7 b. (1136 aa)
	prrc1	Proline-rich coiled-coil 1. (420 aa)
	mthfsd	Methenyltetrahydrofolate synthetase domain containing. (467 aa)
	LOC101169997	Si:dkeyp-93d12.1. (1705 aa)
	LOC101168870	E1A binding protein p300 b. (2760 aa)
	foxh1	Forkhead box H1. (511 aa)
	mib1	Mindbomb E3 ubiquitin protein ligase 1. (1081 aa)
	LOC101167461	NK3 homeobox 1. (188 aa)
	ENSORLP00000035938	Uncharacterized protein. (521 aa)
	LOC101174543	Uncharacterized protein. (733 aa)
	crim1	Uncharacterized protein. (931 aa)
	pld6	Phospholipase D family, member 6. (205 aa)
	LOC101160158	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb; Belongs to the semaphorin family. (796 aa)
	ABI1	Abl-interactor 1a. (641 aa)
	ENSORLP00000037465	Uncharacterized protein. (548 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (398 aa)
	LOC101155494	Uncharacterized protein. (883 aa)
	nle1	Notchless homolog 1 (Drosophila). (478 aa)
	LOC101159120	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (229 aa)
	ENSORLP00000039316	Uncharacterized protein. (281 aa)
	sema3c	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Belongs to the semaphorin family. (763 aa)
	amh-2	Uncharacterized protein. (2436 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (229 aa)
	pdlim7	PDZ and LIM domain 7. (491 aa)
	LOC101159505	Titin-cap (telethonin). (179 aa)
	poglut1	Protein O-glucosyltransferase 1. (387 aa)
	taf10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (186 aa)
	xrcc2	X-ray repair cross complementing 2. (313 aa)
	LOC101172782	Ripply transcriptional repressor 2. (122 aa)
	LOC101163504	Mothers against decapentaplegic homolog. (528 aa)
	tdrkh	Tudor and KH domain containing. (545 aa)
	palb2	PALB2_WD40 domain-containing protein. (1311 aa)
	calcrl	Calcitonin receptor-like a; Belongs to the G-protein coupled receptor 2 family. (476 aa)
	tdrd5	Uncharacterized protein. (932 aa)
	LOC101171247	RAP1A, member of RAS oncogene family a. (202 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	LOC101171596	Notch receptor 1a. (2476 aa)
	rps19	Ribosomal protein S19. (191 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABI1	LOC101170217	ENSORLP00000037107	ENSORLP00000011940	Abl-interactor 1a.	Abl-interactor 1b.	0.901
Atm	ENSORLP00000027619	ENSORLP00000026266	ENSORLP00000027619	Uncharacterized protein.	TAN domain-containing protein.	0.929
Atm	palb2	ENSORLP00000026266	ENSORLP00000043989	Uncharacterized protein.	PALB2_WD40 domain-containing protein.	0.680
Atm	xrcc2	ENSORLP00000026266	ENSORLP00000045844	Uncharacterized protein.	X-ray repair cross complementing 2.	0.682
CHUK	mib1	ENSORLP00000016017	ENSORLP00000034874	Component of inhibitor of nuclear factor kappa B kinase complex.	Mindbomb E3 ubiquitin protein ligase 1.	0.412
ENSORLP00000027619	Atm	ENSORLP00000027619	ENSORLP00000026266	TAN domain-containing protein.	Uncharacterized protein.	0.929
ENSORLP00000027619	palb2	ENSORLP00000027619	ENSORLP00000043989	TAN domain-containing protein.	PALB2_WD40 domain-containing protein.	0.680
ENSORLP00000027619	xrcc2	ENSORLP00000027619	ENSORLP00000045844	TAN domain-containing protein.	X-ray repair cross complementing 2.	0.682
ENSORLP00000035938	xrcc2	ENSORLP00000035938	ENSORLP00000045844	Uncharacterized protein.	X-ray repair cross complementing 2.	0.493
ENSORLP00000037465	amh-2	ENSORLP00000037465	ENSORLP00000039628	Uncharacterized protein.	Uncharacterized protein.	0.487
ENSORLP00000039316	H2ME95_ORYLA	ENSORLP00000039316	ENSORLP00000016899	Uncharacterized protein.	Lysine (K)-specific demethylase 6A.	0.970
ENSORLP00000039316	LOC101161131	ENSORLP00000039316	ENSORLP00000006127	Uncharacterized protein.	Lysine (K)-specific demethylase 6A, like.	0.657
ENSORLP00000039316	palb2	ENSORLP00000039316	ENSORLP00000043989	Uncharacterized protein.	PALB2_WD40 domain-containing protein.	0.425
ENSORLP00000039316	supt6h	ENSORLP00000039316	ENSORLP00000027236	Uncharacterized protein.	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family.	0.613
H2ME95_ORYLA	ENSORLP00000039316	ENSORLP00000016899	ENSORLP00000039316	Lysine (K)-specific demethylase 6A.	Uncharacterized protein.	0.970
H2ME95_ORYLA	LOC101161131	ENSORLP00000016899	ENSORLP00000006127	Lysine (K)-specific demethylase 6A.	Lysine (K)-specific demethylase 6A, like.	0.665
H2ME95_ORYLA	palb2	ENSORLP00000016899	ENSORLP00000043989	Lysine (K)-specific demethylase 6A.	PALB2_WD40 domain-containing protein.	0.425
H2ME95_ORYLA	supt6h	ENSORLP00000016899	ENSORLP00000027236	Lysine (K)-specific demethylase 6A.	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family.	0.613
H2MIJ3_ORYLA	pld6	ENSORLP00000018475	ENSORLP00000036905	Uncharacterized protein.	Phospholipase D family, member 6.	0.448
LOC100049520	foxh1	ENSORLP00000013122	ENSORLP00000032891	POU domain protein.	Forkhead box H1.	0.617