(115 nodes) Response to decreased oxygen levels network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	edn1	Endothelin 1. (220 aa)
	apln	Apelin. (76 aa)
	pick1	Protein interacting with prkca 1. (421 aa)
	ENSORLP00000045591	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (130 aa)
	stox1	Storkhead box 1. (1072 aa)
	LOC101167186	Methyl CpG binding protein 2. (1004 aa)
	LOC101163504	Mothers against decapentaplegic homolog. (528 aa)
	ndnf	Neuron-derived neurotrophic factor. (571 aa)
	LOC101154844	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (410 aa)
	LOC101172686	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (445 aa)
	LOC101175080	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1430 aa)
	eef2k	Eukaryotic elongation factor 2 kinase. (758 aa)
	LOC101173532	FUN14 domain containing 1. (152 aa)
	wtip	WT1 interacting protein. (699 aa)
	LOC101160327	Cytoplasmic polyadenylation element binding protein 4a. (741 aa)
	LOC101165277	ADAM metallopeptidase domain 17b. (844 aa)
	ngb	Neuroglobin; Belongs to the globin family. (185 aa)
	plekhn1	Pleckstrin homology domain containing, family N member 1. (683 aa)
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (627 aa)
	LOC101171872	ADAM metallopeptidase domain 17a. (850 aa)
	egln1	Egl-9 family hypoxia-inducible factor 1a. (385 aa)
	LOC101163391	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (371 aa)
	vegfb	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (237 aa)
	LOC101157575	2-aminoethanethiol (cysteamine) dioxygenase a. (255 aa)
	ajuba	Ajuba. (694 aa)
	vhl	Von Hippel-Lindau tumor suppressor. (166 aa)
	p2rx3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
	LOC101166204	Uncharacterized protein. (534 aa)
	hif1an	Hypoxia inducible factor 1 subunit alpha inhibitor. (359 aa)
	LOC101160921	Si:ch211-39a7.1. (616 aa)
	LOC101167461	NK3 homeobox 1. (188 aa)
	LOC101169126	Zgc:73226. (181 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (378 aa)
	LOC100049501	5-aminolevulinate synthase. (591 aa)
	LOC101161449	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (135 aa)
	tm9sf4	Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (643 aa)
	LOC101175163	Heme oxygenase 2b. (307 aa)
	MYOCD	Myocardin. (884 aa)
	hif1a	Hypoxia inducible factor 1 subunit alpha a. (750 aa)
	LOC101168870	E1A binding protein p300 b. (2760 aa)
	scap	SREBF chaperone. (1355 aa)
	fam167a	Family with sequence similarity 167 member Ab. (207 aa)
	LOC105358811	MADS-box domain-containing protein. (552 aa)
	ENSORLP00000031311	Uncharacterized protein. (248 aa)
	mpl	MPL proto-oncogene, thrombopoietin receptor. (631 aa)
	fam162a	Family with sequence similarity 162 member A. (150 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	epas1	Uncharacterized protein. (404 aa)
	bad	BCL2 associated agonist of cell death b. (164 aa)
	plat	Uncharacterized protein. (607 aa)
	ppard	Uncharacterized protein. (517 aa)
	LOC101173916	Mothers against decapentaplegic homolog. (538 aa)
	cpeb1	Cytoplasmic polyadenylation element binding protein 1b. (584 aa)
	mb	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (147 aa)
	ENSORLP00000028331	2-aminoethanethiol (cysteamine) dioxygenase b. (257 aa)
	ENSORLP00000027381	Lysyl oxidase-like 4. (265 aa)
	cct4	T-complex protein 1 subunit delta. (536 aa)
	ENSORLP00000027113	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (139 aa)
	txn2	Thioredoxin 2. (176 aa)
	pam	Peptidylglycine alpha-amidating monooxygenase. (1013 aa)
	fndc1	Fibronectin type III domain containing 1. (1795 aa)
	LOC101168927	Uncharacterized protein. (519 aa)
	Nf1	Uncharacterized protein. (506 aa)
	rest	RE1-silencing transcription factor. (871 aa)
	hyou1	Hypoxia up-regulated 1. (953 aa)
	egln3	Egl-9 family hypoxia-inducible factor 3. (252 aa)
	aqp1	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (261 aa)
	alkbh5	AlkB homolog 5, RNA demethylase. (361 aa)
	ddit4	DNA-damage-inducible transcript 4. (225 aa)
	LOC101155815	Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (450 aa)
	p2rx2	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (412 aa)
	H2LU26_ORYLA	Lysyl oxidase-like 4. (342 aa)
	ednra	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (439 aa)
	rbpj	Recombination signal binding protein for immunoglobulin kappa J region. (487 aa)
	LOC101164580	Egl-9 family hypoxia-inducible factor 2. (539 aa)
	bnip3	BCL2 interacting protein 3. (193 aa)
	LOC101169800	Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family. (161 aa)
	SMAD4	Mothers against decapentaplegic homolog. (510 aa)
	LIMD1	LIM domains containing 1. (544 aa)
	hsp90b1	Heat shock protein 90, beta (grp94), member 1. (796 aa)
	LOC101172602	Endothelial PAS domain protein 1b. (861 aa)
	LOC101162456	Si:ch73-380n15.2. (560 aa)
	LOC101160197	E1A binding protein p300 a. (2781 aa)
	lonp1	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (964 aa)
	LOC101155037	Transforming growth factor beta; Belongs to the TGF-beta family. (420 aa)
	vegfc	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (494 aa)
	LOC101165163	Hypoxia inducible factor 1 subunit alpha, like. (652 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1023 aa)
	nfe2l2	Nuclear factor, erythroid 2-like 2a. (605 aa)
	bcl2	BCL2 apoptosis regulator b. (202 aa)
	tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (405 aa)
	cpeb2	Cytoplasmic polyadenylation element binding protein 2. (755 aa)
	pink1	PTEN induced kinase 1. (577 aa)
	usf1	Upstream transcription factor 1. (346 aa)
	LOC101163641	Heme oxygenase 2a. (332 aa)
	H2MJT0_ORYLA	Uncharacterized protein. (589 aa)
	tsc1	TSC complex subunit 1b. (1198 aa)
	tbl2	Transducin (beta)-like 2. (465 aa)
	LOC101167346	Uncharacterized protein. (527 aa)
	plau-2	Urokinase type plasminogen activator. (453 aa)
	fundc1	Uncharacterized protein. (165 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (680 aa)
	rgcc	Regulator of cell cycle. (154 aa)
	srf	Serum response factor b. (611 aa)
	LOC101168600	Si:cabz01100188.1. (905 aa)
	H2L4B7_ORYLA	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (737 aa)
	arnt	Aryl hydrocarbon receptor nuclear translocator. (780 aa)
	scfd1	Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (631 aa)
	ak4	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (224 aa)
	LOC101155633	Uncharacterized protein. (617 aa)
	aifm1	Apoptosis inducing factor mitochondrion associated 1. (708 aa)
	ptgs2	EGF-like domain-containing protein. (607 aa)
	plau	Plasminogen activator, urokinase a; Belongs to the peptidase S1 family. (388 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (156 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000027381	H2LU26_ORYLA	ENSORLP00000027381	ENSORLP00000009599	Lysyl oxidase-like 4.	Lysyl oxidase-like 4.	0.893
ENSORLP00000028331	LOC101157575	ENSORLP00000028331	ENSORLP00000037384	2-aminoethanethiol (cysteamine) dioxygenase b.	2-aminoethanethiol (cysteamine) dioxygenase a.	0.902
ENSORLP00000031311	H2L4B7_ORYLA	ENSORLP00000031311	ENSORLP00000000606	Uncharacterized protein.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.850
ENSORLP00000031311	LOC101169800	ENSORLP00000031311	ENSORLP00000007409	Uncharacterized protein.	Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family.	0.550
ENSORLP00000031311	Mtor	ENSORLP00000031311	ENSORLP00000000608	Uncharacterized protein.	Serine/threonine-protein kinase TOR.	0.850
ENSORLP00000031311	cct4	ENSORLP00000031311	ENSORLP00000027193	Uncharacterized protein.	T-complex protein 1 subunit delta.	0.559
ENSORLP00000031311	ddit4	ENSORLP00000031311	ENSORLP00000011504	Uncharacterized protein.	DNA-damage-inducible transcript 4.	0.926
ENSORLP00000031311	hyou1	ENSORLP00000031311	ENSORLP00000024083	Uncharacterized protein.	Hypoxia up-regulated 1.	0.719
ENSORLP00000031311	lonp1	ENSORLP00000031311	ENSORLP00000003055	Uncharacterized protein.	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	0.593
ENSORLP00000031311	pink1	ENSORLP00000031311	ENSORLP00000020035	Uncharacterized protein.	PTEN induced kinase 1.	0.549
ENSORLP00000031311	tsc1	ENSORLP00000031311	ENSORLP00000018027	Uncharacterized protein.	TSC complex subunit 1b.	0.545
H2L4B7_ORYLA	ENSORLP00000031311	ENSORLP00000000606	ENSORLP00000031311	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.850
H2L4B7_ORYLA	Mtor	ENSORLP00000000606	ENSORLP00000000608	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.968
H2L4B7_ORYLA	hsp90b1	ENSORLP00000000606	ENSORLP00000005467	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Heat shock protein 90, beta (grp94), member 1.	0.571
H2L4B7_ORYLA	sirt1	ENSORLP00000000606	ENSORLP00000017142	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Deacetylase sirtuin-type domain-containing protein.	0.597
H2L4B7_ORYLA	tsc1	ENSORLP00000000606	ENSORLP00000018027	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	TSC complex subunit 1b.	0.850
H2LU26_ORYLA	ENSORLP00000027381	ENSORLP00000009599	ENSORLP00000027381	Lysyl oxidase-like 4.	Lysyl oxidase-like 4.	0.893
H2MJT0_ORYLA	Nf1	ENSORLP00000018929	ENSORLP00000026133	Uncharacterized protein.	Uncharacterized protein.	0.943
H2MJT0_ORYLA	tbl2	ENSORLP00000018929	ENSORLP00000018012	Uncharacterized protein.	Transducin (beta)-like 2.	0.443
LIMD1	LOC101164580	ENSORLP00000005761	ENSORLP00000008745	LIM domains containing 1.	Egl-9 family hypoxia-inducible factor 2.	0.539