(47 nodes) Cellular response to decreased oxygen levels network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fndc1	Fibronectin type III domain containing 1. (1795 aa)
	LOC101175080	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1430 aa)
	H2L4B7_ORYLA	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (737 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	fam162a	Family with sequence similarity 162 member A. (150 aa)
	vhl	Von Hippel-Lindau tumor suppressor. (166 aa)
	hif1an	Hypoxia inducible factor 1 subunit alpha inhibitor. (359 aa)
	LOC101167461	NK3 homeobox 1. (188 aa)
	LOC101169126	Zgc:73226. (181 aa)
	pick1	Protein interacting with prkca 1. (421 aa)
	stox1	Storkhead box 1. (1072 aa)
	ndnf	Neuron-derived neurotrophic factor. (571 aa)
	ppard	Uncharacterized protein. (517 aa)
	LOC101157575	2-aminoethanethiol (cysteamine) dioxygenase a. (255 aa)
	bad	BCL2 associated agonist of cell death b. (164 aa)
	epas1	Uncharacterized protein. (404 aa)
	mpl	MPL proto-oncogene, thrombopoietin receptor. (631 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1023 aa)
	LOC101165163	Hypoxia inducible factor 1 subunit alpha, like. (652 aa)
	LOC101172602	Endothelial PAS domain protein 1b. (861 aa)
	bnip3	BCL2 interacting protein 3. (193 aa)
	LOC101164580	Egl-9 family hypoxia-inducible factor 2. (539 aa)
	rbpj	Recombination signal binding protein for immunoglobulin kappa J region. (487 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (450 aa)
	ptgs2	EGF-like domain-containing protein. (607 aa)
	aifm1	Apoptosis inducing factor mitochondrion associated 1. (708 aa)
	ak4	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (224 aa)
	rgcc	Regulator of cell cycle. (154 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (680 aa)
	tbl2	Transducin (beta)-like 2. (465 aa)
	tsc1	TSC complex subunit 1b. (1198 aa)
	pink1	PTEN induced kinase 1. (577 aa)
	cpeb2	Cytoplasmic polyadenylation element binding protein 2. (755 aa)
	bcl2	BCL2 apoptosis regulator b. (202 aa)
	nfe2l2	Nuclear factor, erythroid 2-like 2a. (605 aa)
	aqp1	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (261 aa)
	egln3	Egl-9 family hypoxia-inducible factor 3. (252 aa)
	hyou1	Hypoxia up-regulated 1. (953 aa)
	eef2k	Eukaryotic elongation factor 2 kinase. (758 aa)
	LOC101160327	Cytoplasmic polyadenylation element binding protein 4a. (741 aa)
	egln1	Egl-9 family hypoxia-inducible factor 1a. (385 aa)
	ENSORLP00000031311	Uncharacterized protein. (248 aa)
	cpeb1	Cytoplasmic polyadenylation element binding protein 1b. (584 aa)
	ENSORLP00000028331	2-aminoethanethiol (cysteamine) dioxygenase b. (257 aa)
	fam167a	Family with sequence similarity 167 member Ab. (207 aa)
	hif1a	Hypoxia inducible factor 1 subunit alpha a. (750 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (378 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000028331	LOC101157575	ENSORLP00000028331	ENSORLP00000037384	2-aminoethanethiol (cysteamine) dioxygenase b.	2-aminoethanethiol (cysteamine) dioxygenase a.	0.902
ENSORLP00000031311	H2L4B7_ORYLA	ENSORLP00000031311	ENSORLP00000000606	Uncharacterized protein.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.850
ENSORLP00000031311	Mtor	ENSORLP00000031311	ENSORLP00000000608	Uncharacterized protein.	Serine/threonine-protein kinase TOR.	0.850
ENSORLP00000031311	hyou1	ENSORLP00000031311	ENSORLP00000024083	Uncharacterized protein.	Hypoxia up-regulated 1.	0.719
ENSORLP00000031311	pink1	ENSORLP00000031311	ENSORLP00000020035	Uncharacterized protein.	PTEN induced kinase 1.	0.549
ENSORLP00000031311	tsc1	ENSORLP00000031311	ENSORLP00000018027	Uncharacterized protein.	TSC complex subunit 1b.	0.545
H2L4B7_ORYLA	ENSORLP00000031311	ENSORLP00000000606	ENSORLP00000031311	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.850
H2L4B7_ORYLA	Mtor	ENSORLP00000000606	ENSORLP00000000608	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.968
H2L4B7_ORYLA	sirt1	ENSORLP00000000606	ENSORLP00000017142	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Deacetylase sirtuin-type domain-containing protein.	0.597
H2L4B7_ORYLA	tsc1	ENSORLP00000000606	ENSORLP00000018027	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	TSC complex subunit 1b.	0.850
LOC101157575	ENSORLP00000028331	ENSORLP00000037384	ENSORLP00000028331	2-aminoethanethiol (cysteamine) dioxygenase a.	2-aminoethanethiol (cysteamine) dioxygenase b.	0.902
LOC101160327	cpeb1	ENSORLP00000043290	ENSORLP00000029310	Cytoplasmic polyadenylation element binding protein 4a.	Cytoplasmic polyadenylation element binding protein 1b.	0.629
LOC101160327	cpeb2	ENSORLP00000043290	ENSORLP00000020310	Cytoplasmic polyadenylation element binding protein 4a.	Cytoplasmic polyadenylation element binding protein 2.	0.623
LOC101164580	LOC101165163	ENSORLP00000008745	ENSORLP00000002499	Egl-9 family hypoxia-inducible factor 2.	Hypoxia inducible factor 1 subunit alpha, like.	0.805
LOC101164580	LOC101172602	ENSORLP00000008745	ENSORLP00000004403	Egl-9 family hypoxia-inducible factor 2.	Endothelial PAS domain protein 1b.	0.805
LOC101164580	epas1	ENSORLP00000008745	ENSORLP00000030184	Egl-9 family hypoxia-inducible factor 2.	Uncharacterized protein.	0.805
LOC101164580	hif1a	ENSORLP00000008745	ENSORLP00000032596	Egl-9 family hypoxia-inducible factor 2.	Hypoxia inducible factor 1 subunit alpha a.	0.809
LOC101164580	vhl	ENSORLP00000008745	ENSORLP00000037027	Egl-9 family hypoxia-inducible factor 2.	Von Hippel-Lindau tumor suppressor.	0.774
LOC101165163	LOC101164580	ENSORLP00000002499	ENSORLP00000008745	Hypoxia inducible factor 1 subunit alpha, like.	Egl-9 family hypoxia-inducible factor 2.	0.805
LOC101165163	bcl2	ENSORLP00000002499	ENSORLP00000021005	Hypoxia inducible factor 1 subunit alpha, like.	BCL2 apoptosis regulator b.	0.461