(86 nodes) B cell activation network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101171170	MALT paracaspase 1. (811 aa)
	sash3	SAM and SH3 domain containing 3. (391 aa)
	LOC101167049	CD40 ligand; Belongs to the tumor necrosis factor family. (239 aa)
	cxcr5	Chemokine (C-X-C motif) receptor 5; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	LOC101160197	E1A binding protein p300 a. (2781 aa)
	phb	Prohibitin. (299 aa)
	LOC101164045	SEFIR domain-containing protein. (443 aa)
	LOC101175459	BHLH domain-containing protein. (457 aa)
	lef1	Lymphoid enhancer-binding factor 1. (379 aa)
	ung	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (298 aa)
	dock10	Dedicator of cytokinesis 10; Belongs to the DOCK family. (1989 aa)
	txn	Thioredoxin; Belongs to the thioredoxin family. (106 aa)
	nkx2-3	NK2 homeobox 3. (341 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
	LOC101159746	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
	batf	Basic leucine zipper transcription factor, ATF-like. (121 aa)
	dnajb9	DnaJ heat shock protein family (Hsp40) member B9b. (227 aa)
	LOC101166554	ATPase family AAA domain containing 5a. (1758 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
	ITM2A	Integral membrane protein 2A. (246 aa)
	LOC101172736	Galectin. (153 aa)
	H2M4R0_ORYLA	Galectin. (110 aa)
	msh6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1381 aa)
	cd79b	Ig-like domain-containing protein. (206 aa)
	rag1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1090 aa)
	rag2	Recombination activating gene 2. (532 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (516 aa)
	tpd52	Tumor protein D52. (235 aa)
	H2ME78_ORYLA	SEFIR domain-containing protein. (115 aa)
	card11	Caspase recruitment domain family, member 11. (1146 aa)
	LOC101157986	Sp3b transcription factor. (614 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (709 aa)
	Traf3ip2	SEFIR domain-containing protein. (116 aa)
	zbtb1	Zinc finger and BTB domain containing 1. (684 aa)
	ercc1	Excision repair cross-complementation group 1. (341 aa)
	bcl2	BCL2 apoptosis regulator b. (202 aa)
	SP3	Sp3a transcription factor. (668 aa)
	H2MU64_ORYLA	Chemokine (C-C motif) receptor 6b; Belongs to the G-protein coupled receptor 1 family. (413 aa)
	tnfsf13b	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (252 aa)
	CEBPG	CCAAT enhancer binding protein gamma. (162 aa)
	Atm	Uncharacterized protein. (147 aa)
	aicda	Activation-induced cytidine deaminase. (211 aa)
	ENSORLP00000027619	TAN domain-containing protein. (321 aa)
	kiaa1841	Si:ch211-189k9.2. (890 aa)
	LOC111947756	Galectin. (167 aa)
	LOC101161464	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
	LOC101169785	Galectin. (135 aa)
	pou2af1	Uncharacterized protein. (296 aa)
	ENSORLP00000030535	Fibronectin type-III domain-containing protein. (383 aa)
	ENSORLP00000030740	J domain-containing protein. (144 aa)
	LOC105356386	DBB domain-containing protein. (589 aa)
	DCAF1	DDB1 and CUL4 associated factor 1. (1456 aa)
	LOC101168870	E1A binding protein p300 b. (2760 aa)
	cmtm7	CKLF-like MARVEL transmembrane domain containing 7. (207 aa)
	exosc3	Exosome component 3. (250 aa)
	skap2	Src kinase associated phosphoprotein 2. (345 aa)
	LOC110017164	Interferon a3-like. (187 aa)
	lcp2	Lymphocyte cytosolic protein 2a. (504 aa)
	LOC100301586	CD40 molecule, TNF receptor superfamily member 5. (305 aa)
	ENSORLP00000034311	Uncharacterized protein. (147 aa)
	LOC110014574	CARD domain-containing protein. (186 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (720 aa)
	LOC110017164-2	CARD domain-containing protein. (187 aa)
	LOC101164986	Si:dkey-27c15.3. (1313 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1343 aa)
	ENSORLP00000035693	Galectin. (147 aa)
	LOC101155757	Galectin. (131 aa)
	lig4	DNA ligase. (912 aa)
	NKX2-3	NK2 homeobox 3. (351 aa)
	LOC101172133	ATPase family AAA domain containing 5b. (959 aa)
	LOC101164921	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
	gon4l	Uncharacterized protein. (1087 aa)
	Gon4l	Uncharacterized protein. (435 aa)
	LOC110013317	Galectin. (135 aa)
	LOC101158686	MALT paracaspase 2. (843 aa)
	LOC101168687	Zgc:153993. (293 aa)
	LOC101158194	MALT paracaspase 3. (557 aa)
	ccr6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (376 aa)
	LOC101162065	B cell linker. (553 aa)
	LOC101172497	Galectin. (135 aa)
	cd79a	CD79a molecule, immunoglobulin-associated alpha. (220 aa)
	LOC111947758	Galectin. (135 aa)
	itfg2	Integrin alpha FG-GAP repeat containing 2. (434 aa)
	LOC111946454	Interferon a3-like. (186 aa)
	rabl3	RAB, member of RAS oncogene family-like 3. (243 aa)
	fnip1	Folliculin interacting protein 1. (1246 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atm	ENSORLP00000027619	ENSORLP00000026266	ENSORLP00000027619	Uncharacterized protein.	TAN domain-containing protein.	0.929
Atm	LOC101166554	ENSORLP00000026266	ENSORLP00000012809	Uncharacterized protein.	ATPase family AAA domain containing 5a.	0.556
Atm	LOC101172133	ENSORLP00000026266	ENSORLP00000038541	Uncharacterized protein.	ATPase family AAA domain containing 5b.	0.556
Atm	ercc1	ENSORLP00000026266	ENSORLP00000020313	Uncharacterized protein.	Excision repair cross-complementation group 1.	0.574
Atm	lig4	ENSORLP00000026266	ENSORLP00000037330	Uncharacterized protein.	DNA ligase.	0.620
Atm	mlh1	ENSORLP00000026266	ENSORLP00000034579	Uncharacterized protein.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.768
Atm	msh2	ENSORLP00000026266	ENSORLP00000012873	Uncharacterized protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.674
Atm	msh6	ENSORLP00000026266	ENSORLP00000013893	Uncharacterized protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.667
Atm	rnf8	ENSORLP00000026266	ENSORLP00000015004	Uncharacterized protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.698
CEBPG	aicda	ENSORLP00000023313	ENSORLP00000026417	CCAAT enhancer binding protein gamma.	Activation-induced cytidine deaminase.	0.457
DCAF1	ung	ENSORLP00000031046	ENSORLP00000008939	DDB1 and CUL4 associated factor 1.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.893
ENSORLP00000027619	Atm	ENSORLP00000027619	ENSORLP00000026266	TAN domain-containing protein.	Uncharacterized protein.	0.929
ENSORLP00000027619	LOC101166554	ENSORLP00000027619	ENSORLP00000012809	TAN domain-containing protein.	ATPase family AAA domain containing 5a.	0.556
ENSORLP00000027619	LOC101172133	ENSORLP00000027619	ENSORLP00000038541	TAN domain-containing protein.	ATPase family AAA domain containing 5b.	0.556
ENSORLP00000027619	ercc1	ENSORLP00000027619	ENSORLP00000020313	TAN domain-containing protein.	Excision repair cross-complementation group 1.	0.574
ENSORLP00000027619	lig4	ENSORLP00000027619	ENSORLP00000037330	TAN domain-containing protein.	DNA ligase.	0.620
ENSORLP00000027619	mlh1	ENSORLP00000027619	ENSORLP00000034579	TAN domain-containing protein.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.768
ENSORLP00000027619	msh2	ENSORLP00000027619	ENSORLP00000012873	TAN domain-containing protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.674
ENSORLP00000027619	msh6	ENSORLP00000027619	ENSORLP00000013893	TAN domain-containing protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.667
ENSORLP00000027619	rnf8	ENSORLP00000027619	ENSORLP00000015004	TAN domain-containing protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.698