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srd5a1 srd5a1 LOC101164311 LOC101164311 kyat1 kyat1 cyp17a2 cyp17a2 coq2 coq2 kmo kmo cbr1 cbr1 LOC100125474 LOC100125474 ubiad1 ubiad1 LOC101169805 LOC101169805 LOC101165489 LOC101165489 vkorc1 vkorc1 coq4 coq4 LOC101155532 LOC101155532 got2 got2 LOC101161407 LOC101161407 ednr ednr LOC101165021 LOC101165021 LOC101165274 LOC101165274 LOC101167965 LOC101167965 LOC101158386 LOC101158386 H2M6L1_ORYLA H2M6L1_ORYLA afmid afmid kynu kynu glod4 glod4 park7 park7 LOC101156869 LOC101156869 coq8a coq8a HAGHL HAGHL hsd17b3 hsd17b3 LOC101155688 LOC101155688 LOC101170381 LOC101170381 vkorc1l1 vkorc1l1 coq5 coq5 coq3 coq3 nqo1 nqo1 hsd17b10 hsd17b10 pdss2 pdss2 LOC101175554 LOC101175554 AIFM2 AIFM2 LOC100125532 LOC100125532 pdss1 pdss1 coq6 coq6 aadat aadat ENSORLP00000026404 ENSORLP00000026404 gatd1 gatd1 coq10b coq10b cryzl1 cryzl1 tdo2 tdo2 LOC101175460 LOC101175460 cyp17 cyp17 LOC111946266 LOC111946266 LOC100049225 LOC100049225 kdsr kdsr aldh8a1 aldh8a1 LOC101173380 LOC101173380 ndufa9 ndufa9 coq9 coq9 sirt6 sirt6 GLO1 GLO1 coq7 coq7 tpi1 tpi1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
srd5a13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (264 aa)
LOC101164311Si:ch73-141c7.1. (235 aa)
kyat1Kynurenine aminotransferase 1. (446 aa)
cyp17a2Cytochrome P450 family 17 polypeptide 2; Belongs to the cytochrome P450 family. (521 aa)
coq24-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (375 aa)
kmoKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (505 aa)
cbr1Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (324 aa)
LOC100125474Hydroxysteroid (11-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (407 aa)
ubiad1UbiA prenyltransferase domain containing 1. (405 aa)
LOC101169805Uncharacterized protein. (418 aa)
LOC101165489Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (248 aa)
vkorc1Vitamin K epoxide reductase complex, subunit 1. (167 aa)
coq4Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. (274 aa)
LOC101155532Coenzyme Q8B. (638 aa)
got2Aspartate aminotransferase. (428 aa)
LOC101161407Hydroxyacylglutathione hydrolase. (309 aa)
ednrG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (413 aa)
LOC101165021Uncharacterized protein. (507 aa)
LOC101165274Uncharacterized protein. (507 aa)
LOC101167965Indoleamine 2,3-dioxygenase 1. (420 aa)
LOC101158386Endothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (419 aa)
H2M6L1_ORYLASi:ch73-71c20.5. (150 aa)
afmidArylformamidase. (291 aa)
kynuKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (464 aa)
glod4Glyoxalase domain containing 4. (285 aa)
park7DJ-1. (189 aa)
LOC1011568693-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (253 aa)
coq8aCoenzyme Q8A, genome duplicate a. (655 aa)
HAGHLHydroxyacylglutathione hydrolase like. (282 aa)
hsd17b3Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (349 aa)
LOC101155688Coenzyme Q10A. (252 aa)
LOC101170381Flavodoxin_2 domain-containing protein. (292 aa)
vkorc1l1Vitamin K epoxide reductase complex, subunit 1-like 1. (226 aa)
coq52-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (338 aa)
coq3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (328 aa)
nqo1Flavodoxin_2 domain-containing protein. (270 aa)
hsd17b10Hydroxysteroid (17-beta) dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)
pdss2Prenyl (decaprenyl) diphosphate synthase, subunit 2; Belongs to the FPP/GGPP synthase family. (384 aa)
LOC101175554PNKD metallo-beta-lactamase domain containing. (360 aa)
AIFM2Apoptosis inducing factor mitochondria associated 2. (372 aa)
LOC1001255323-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (294 aa)
pdss1Prenyl (decaprenyl) diphosphate synthase, subunit 1; Belongs to the FPP/GGPP synthase family. (419 aa)
coq6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (496 aa)
aadatAminoadipate aminotransferase. (431 aa)
ENSORLP00000026404Uncharacterized protein. (204 aa)
gatd1Glutamine amidotransferase like class 1 domain containing 1. (213 aa)
coq10bCoenzyme Q10B. (238 aa)
cryzl1Crystallin, zeta (quinone reductase)-like 1. (348 aa)
tdo2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (468 aa)
LOC101175460Coenzyme Q8A, genome duplicate b. (564 aa)
cyp17Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction; Belongs to the cytochrome P450 family. (595 aa)
LOC111946266NAD(P)H dehydrogenase, quinone 1. (230 aa)
LOC100049225Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family. (427 aa)
kdsr3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (332 aa)
aldh8a1Aldehyde dehydrogenase 8 family, member A1; Belongs to the aldehyde dehydrogenase family. (490 aa)
LOC101173380Kynurenine aminotransferase 3. (448 aa)
ndufa9NADH:ubiquinone oxidoreductase subunit A9a. (421 aa)
coq9Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. (357 aa)
sirt6Sirtuin 6. (347 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (179 aa)
coq7Coenzyme Q7 homolog, ubiquinone (yeast). (248 aa)
tpi1Triosephosphate isomerase. (247 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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