(140 nodes) Apical junction complex network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101158954	Cingulin b. (1173 aa)
	LOC101160050	Uncharacterized protein. (1412 aa)
	H2L4Q8_ORYLA	Uncharacterized protein. (259 aa)
	LOC101163423	MARVEL domain containing 2a. (556 aa)
	LOC101166566	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	LOC101174288	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (781 aa)
	LOC101159211	Uncharacterized protein. (172 aa)
	H2L717_ORYLA	Uncharacterized protein. (182 aa)
	LOC101159688	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
	H2L729_ORYLA	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (237 aa)
	H2L737_ORYLA	Uncharacterized protein. (151 aa)
	H2L7D2_ORYLA	Uncharacterized protein. (176 aa)
	pard3	Par-3 family cell polarity regulator alpha, b. (1389 aa)
	frmpd2	FERM and PDZ domain containing 2. (776 aa)
	H2LCI4_ORYLA	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (271 aa)
	H2LCK0_ORYLA	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (198 aa)
	H2LCK1_ORYLA	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (109 aa)
	H2LCK7_ORYLA	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (201 aa)
	MTDH	Uncharacterized protein. (537 aa)
	H2LCN0_ORYLA	Zgc:136892. (282 aa)
	cldn11	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
	tjap1	Tight junction associated protein 1 (peripheral). (537 aa)
	H2LE16_ORYLA	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (275 aa)
	H2LE26_ORYLA	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (256 aa)
	H2LE29_ORYLA	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
	LOC101161011	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
	H2LES7_ORYLA	Uncharacterized protein. (585 aa)
	LOC101172061	Si:busm1-52i16.2. (343 aa)
	nphp1	Nephronophthisis 1. (532 aa)
	MPDZ	Multiple PDZ domain crumbs cell polarity complex component. (1695 aa)
	LOC101174465	FERM domain-containing protein. (423 aa)
	LOC101156528	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (212 aa)
	MPDZ-2	Uncharacterized protein. (1911 aa)
	LOC101156758	Uncharacterized protein. (382 aa)
	LOC101168608	Lin-7 homolog C (C. elegans); Belongs to the eukaryotic ribosomal protein P1/P2 family. (287 aa)
	LOC101165134	Pleckstrin homology domain containing, family A member 7b. (1359 aa)
	LOC101165395	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	sapcd2	Suppressor APC domain containing 2. (453 aa)
	tbcd	Tubulin folding cofactor D. (1195 aa)
	LOC101160155	Membrane associated guanylate kinase, WW and PDZ domain containing 3b. (1467 aa)
	cgnl1	Cingulin-like 1. (1300 aa)
	vcl	Vinculin b. (1066 aa)
	crb1	Crumbs cell polarity complex component 1. (1325 aa)
	H2LZ82_ORYLA	Uncharacterized protein. (708 aa)
	LOC101170697	Nectin cell adhesion molecule 3b. (587 aa)
	LOC101168988	Uncharacterized protein; Belongs to the MAGUK family. (539 aa)
	frmd4a	FERM domain containing 4A. (1056 aa)
	LOC101158790	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (212 aa)
	ccdc85c	Coiled-coil domain containing 85C. (404 aa)
	PMP22	Peripheral myelin protein 22b. (152 aa)
	H2M6P6_ORYLA	Claudin 23a. (252 aa)
	LOC101166173	Claudin 11a. (219 aa)
	pdcd6ip	Programmed cell death 6 interacting protein. (882 aa)
	mpp5	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (646 aa)
	cldn19	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
	cxadr	CXADR Ig-like cell adhesion molecule. (375 aa)
	LOC101156666	Uncharacterized protein. (1426 aa)
	ildr2	Immunoglobulin-like domain containing receptor 2. (621 aa)
	clmp	Uncharacterized protein. (384 aa)
	frmd4b	FERM domain containing 4Bb. (978 aa)
	LOC101165637	Matrix-remodelling associated 8b. (443 aa)
	LOC105356918	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (241 aa)
	H2MJP6_ORYLA	Uncharacterized protein. (428 aa)
	H2MK39_ORYLA	Uncharacterized protein. (1388 aa)
	H2MKK9_ORYLA	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (262 aa)
	LOC101162919	Tight junction protein 3; Belongs to the MAGUK family. (1334 aa)
	amotl2	Angiomotin like 2a. (697 aa)
	LOC101169283	Uncharacterized protein. (428 aa)
	magi2	Membrane associated guanylate kinase, WW and PDZ domain containing 2a. (1331 aa)
	LOC101159857	Angiomotin like 2b. (688 aa)
	marveld2	MARVEL domain containing 2b. (583 aa)
	CLDN20	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (242 aa)
	prkci	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (554 aa)
	LOC101168439	Par-6 family cell polarity regulator alpha. (390 aa)
	LOC101155569	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
	arhgef2	Rho/rac guanine nucleotide exchange factor (GEF) 2. (896 aa)
	mpp7	Membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7); Belongs to the MAGUK family. (594 aa)
	MPP5	Membrane palmitoylated protein 5; Belongs to the MAGUK family. (667 aa)
	tjp2	Tight junction protein 2a (zona occludens 2); Belongs to the MAGUK family. (1255 aa)
	Cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (109 aa)
	pard6b	Par-6 partitioning defective 6 homolog beta (C. elegans). (399 aa)
	LOC101174779	Uncharacterized protein. (395 aa)
	LOC101159702	Lipolysis stimulated lipoprotein receptor. (608 aa)
	SHROOM2	Shroom family member 2. (1645 aa)
	LOC101160233	Tight junction protein 1b; Belongs to the MAGUK family. (1856 aa)
	LOC101166512	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (254 aa)
	LOC101158679	IG domain-containing protein. (763 aa)
	LOC101158948	Uncharacterized protein. (394 aa)
	LOC101173650	FERM domain-containing protein. (565 aa)
	LOC101166369	Tight junction protein 1a; Belongs to the MAGUK family. (1748 aa)
	pof1b	POF1B actin binding protein. (659 aa)
	LOC101163521	Zgc:154006. (518 aa)
	ect2	Epithelial cell transforming 2. (1098 aa)
	lin7b	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (220 aa)
	LOC101173457	DUF3338 domain-containing protein. (616 aa)
	LOC101170762	Cytohesin 1a. (418 aa)
	ENSORLP00000031308	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
	ctnnb1	Catenin (cadherin-associated protein), beta 1. (783 aa)
	bves	Blood vessel epicardial substance. (356 aa)
	PARD3	Par-3 family cell polarity regulator. (1373 aa)
	LOC101174688	Junctional adhesion molecule 3b. (302 aa)
	LOC101169307	Angiomotin. (1061 aa)
	magi1	Membrane associated guanylate kinase, WW and PDZ domain containing 1b. (1724 aa)
	ENSORLP00000033296	Claudin b. (205 aa)
	rab13	Uncharacterized protein. (242 aa)
	ENSORLP00000033341	PDZ domain-containing protein. (108 aa)
	LOC101171613	Cytohesin 1b. (420 aa)
	lin7a	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (217 aa)
	jam3	Junctional adhesion molecule 3a. (315 aa)
	LOC101169477	Shroom family member 1. (1569 aa)
	ENSORLP00000034823	PDZ domain-containing protein. (101 aa)
	jam2	Junctional adhesion molecule 2a. (406 aa)
	LOC101173221	Membrane associated guanylate kinase, WW and PDZ domain containing 2b. (1528 aa)
	ENSORLP00000035543	PDZ domain-containing protein. (151 aa)
	cgn	Cingulin a. (1223 aa)
	plekha7	Pleckstrin homology domain containing, family A member 7a. (1389 aa)
	LOC101169467	Par-6 family cell polarity regulator gamma b. (448 aa)
	crb2	Uncharacterized protein. (1464 aa)
	ENSORLP00000037368	Uncharacterized protein. (187 aa)
	LOC101168460	Membrane associated guanylate kinase, WW and PDZ domain containing 1a. (1585 aa)
	ENSORLP00000039435	PDZ domain-containing protein. (523 aa)
	ENSORLP00000039853	ASD2 domain-containing protein. (127 aa)
	LOC101172101	Vinculin a. (1135 aa)
	ENSORLP00000039963	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (174 aa)
	LOC101159504	Uncharacterized protein. (1413 aa)
	ENSORLP00000040420	Uncharacterized protein. (70 aa)
	LOC101163115	SH3-domain binding protein 1. (756 aa)
	ENSORLP00000040831	Par3_HAL_N_term domain-containing protein. (72 aa)
	LOC101169436	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (545 aa)
	c1qtnf5	C1q and TNF related 5. (283 aa)
	cyth2	Cytohesin 2. (416 aa)
	ENSORLP00000042011	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
	LOC101164537	Uncharacterized protein. (1179 aa)
	ENSORLP00000042461	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (180 aa)
	LOC101158670	Uncharacterized protein. (767 aa)
	LOC101163673	Occludin a. (497 aa)
	frmd6	FERM domain containing 6. (602 aa)
	nectin1	Nectin cell adhesion molecule 1b. (526 aa)
	esam	Endothelial cell adhesion molecule a. (451 aa)
	LOC105355609	F11 receptor, tandem duplicate 1. (298 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLDN20	Cldn5	ENSORLP00000021675	ENSORLP00000026956	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.667
CLDN20	ENSORLP00000031308	ENSORLP00000021675	ENSORLP00000031308	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.659
CLDN20	ENSORLP00000033296	ENSORLP00000021675	ENSORLP00000033296	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin b.	0.657
CLDN20	ENSORLP00000042011	ENSORLP00000021675	ENSORLP00000042011	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
CLDN20	ENSORLP00000042461	ENSORLP00000021675	ENSORLP00000042461	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.677
CLDN20	H2L717_ORYLA	ENSORLP00000021675	ENSORLP00000001625	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.667
CLDN20	H2L729_ORYLA	ENSORLP00000021675	ENSORLP00000001637	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
CLDN20	H2L737_ORYLA	ENSORLP00000021675	ENSORLP00000001645	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.657
CLDN20	H2L7D2_ORYLA	ENSORLP00000021675	ENSORLP00000001743	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.724
CLDN20	H2LCI4_ORYLA	ENSORLP00000021675	ENSORLP00000003622	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
CLDN20	H2LCK1_ORYLA	ENSORLP00000021675	ENSORLP00000003640	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
CLDN20	H2LCK7_ORYLA	ENSORLP00000021675	ENSORLP00000003646	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
CLDN20	H2LCN0_ORYLA	ENSORLP00000021675	ENSORLP00000003670	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Zgc:136892.	0.664
CLDN20	H2LE26_ORYLA	ENSORLP00000021675	ENSORLP00000004193	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.667
CLDN20	H2LE29_ORYLA	ENSORLP00000021675	ENSORLP00000004196	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.691
CLDN20	H2M6P6_ORYLA	ENSORLP00000021675	ENSORLP00000014143	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin 23a.	0.737
CLDN20	LOC101155569	ENSORLP00000021675	ENSORLP00000025334	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.667
CLDN20	LOC101156528	ENSORLP00000021675	ENSORLP00000005747	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.670
CLDN20	LOC101158790	ENSORLP00000021675	ENSORLP00000012777	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.667
CLDN20	LOC101159211	ENSORLP00000021675	ENSORLP00000001623	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.667