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pik3r5 pik3r5 map2k5 map2k5 H2L9W7_ORYLA H2L9W7_ORYLA LOC101159013 LOC101159013 LOC101165892 LOC101165892 Fgf1 Fgf1 spry4 spry4 LOC101157631 LOC101157631 cav3 cav3 LOC101164385 LOC101164385 tsg101 tsg101 ENSORLP00000045591 ENSORLP00000045591 cdk5rap3 cdk5rap3 trib2 trib2 LOC101166399 LOC101166399 LOC105356874 LOC105356874 tnfrsf11a tnfrsf11a il34 il34 LOC101174103 LOC101174103 LOC111949269 LOC111949269 LOC101163346 LOC101163346 LOC101166888 LOC101166888 fgf18 fgf18 LOC101155494 LOC101155494 LOC101155444 LOC101155444 ajuba ajuba map3k4 map3k4 LOC101166855 LOC101166855 LOC101169209 LOC101169209 ENSORLP00000036607 ENSORLP00000036607 dtnbp1 dtnbp1 pdgfc pdgfc ptprc ptprc LOC101166327 LOC101166327 pdcd10 pdcd10 LOC101169592 LOC101169592 SAMD5-2 SAMD5-2 LOC100301586 LOC100301586 aida aida map2k7 map2k7 tpd52l1 tpd52l1 map3k13 map3k13 tmem130 tmem130 vegfa vegfa LOC101160820 LOC101160820 LOC101166028 LOC101166028 lime1 lime1 map3k7 map3k7 pdgfb pdgfb Nf1 Nf1 LOC101173120 LOC101173120 lrrk2 lrrk2 LOC101173126 LOC101173126 paqr3 paqr3 LOC100125499 LOC100125499 nek10 nek10 SPRY3 SPRY3 PIK3R5 PIK3R5 H2MJT0_ORYLA H2MJT0_ORYLA fgfr1 fgfr1 sash1 sash1 LOC101161673 LOC101161673 LOC101168659 LOC101168659 LOC101165149 LOC101165149 bmp4 bmp4 LOC101160746 LOC101160746 dusp10 dusp10 PAQR3 PAQR3 LOC101171428 LOC101171428 nox4 nox4 fzd4 fzd4 LOC101172593 LOC101172593 LOC101171139 LOC101171139 H2M3J6_ORYLA H2M3J6_ORYLA gba gba sorl1 sorl1 pik3cg pik3cg edn1 edn1 ern1 ern1 LOC101162428 LOC101162428 pdgfa pdgfa tenm1 tenm1 sfrp2 sfrp2 htr2b htr2b hgs hgs LOC101172518 LOC101172518 LOC101161650 LOC101161650 agt agt axin1 axin1 Fzd8 Fzd8 smpd1 smpd1 LOC101171145 LOC101171145 sh2b3 sh2b3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pik3r5Phosphoinositide-3-kinase, regulatory subunit 5. (883 aa)
map2k5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (445 aa)
H2L9W7_ORYLAUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
LOC101159013Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1106 aa)
LOC101165892EGF-like domain-containing protein. (162 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (159 aa)
spry4Sprouty homolog 4 (Drosophila). (378 aa)
LOC101157631Transforming growth factor beta; Belongs to the TGF-beta family. (444 aa)
cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
LOC101164385Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (383 aa)
tsg101Tumor susceptibility 101a. (384 aa)
ENSORLP00000045591Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (130 aa)
cdk5rap3CDK5 regulatory subunit associated protein 3. (500 aa)
trib2Tribbles pseudokinase 2. (345 aa)
LOC101166399Apolipoprotein Ea. (262 aa)
LOC105356874Protein kinase domain-containing protein. (501 aa)
tnfrsf11aTumor necrosis factor receptor superfamily, member 11a, NFKB activator. (639 aa)
il34Interleukin 34. (236 aa)
LOC101174103Si:dkey-70p6.1. (432 aa)
LOC111949269Uncharacterized protein. (927 aa)
LOC101163346Bone morphogenetic protein 16. (516 aa)
LOC1011668883-hydroxy-3-methylglutaryl coenzyme A reductase. (853 aa)
fgf18Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
LOC101155494Uncharacterized protein. (883 aa)
LOC101155444Uncharacterized protein. (1910 aa)
ajubaAjuba. (694 aa)
map3k4Mitogen-activated protein kinase kinase kinase 4. (1590 aa)
LOC101166855Transforming growth factor, alpha. (254 aa)
LOC101169209Uncharacterized protein. (283 aa)
ENSORLP00000036607Uncharacterized protein. (251 aa)
dtnbp1Dystrobrevin binding protein 1b. (259 aa)
pdgfcPlatelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (342 aa)
ptprcProtein tyrosine phosphatase receptor type C. (1343 aa)
LOC101166327Si:dkey-175m17.7. (881 aa)
pdcd10Programmed cell death 10b. (210 aa)
LOC101169592Dual specificity phosphatase 19b. (208 aa)
SAMD5-2SAM domain-containing protein. (178 aa)
LOC100301586CD40 molecule, TNF receptor superfamily member 5. (305 aa)
aidaAxin interactor, dorsalization associated. (305 aa)
map2k7Mitogen-activated protein kinase kinase 7. (477 aa)
tpd52l1Tpd52 like 1. (220 aa)
map3k13Mitogen-activated protein kinase kinase kinase. (1002 aa)
tmem130Transmembrane protein 130. (311 aa)
vegfaVascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
LOC101160820SCY domain-containing protein. (131 aa)
LOC101166028Zgc:123278. (182 aa)
lime1Uncharacterized protein. (553 aa)
map3k7Mitogen-activated protein kinase kinase kinase 7. (595 aa)
pdgfbPlatelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (553 aa)
Nf1Uncharacterized protein. (506 aa)
LOC101173120G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (390 aa)
lrrk2Leucine-rich repeat kinase 2. (2241 aa)
LOC101173126Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family. (382 aa)
paqr3Progestin and adipoQ receptor family member IIIa. (310 aa)
LOC1001254993-hydroxy-3-methylglutaryl coenzyme A reductase. (865 aa)
nek10NIMA-related kinase 10. (998 aa)
SPRY3Sprouty RTK signaling antagonist 3. (273 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (861 aa)
H2MJT0_ORYLAUncharacterized protein. (589 aa)
fgfr1Fibroblast growth factor receptor. (833 aa)
sash1SAM and SH3 domain containing 1a. (1225 aa)
LOC101161673Apolipoprotein Eb. (265 aa)
LOC101168659Dual specificity phosphatase 19a. (207 aa)
LOC101165149Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (510 aa)
bmp4Bone morphogenetic protein 4. (441 aa)
LOC101160746Tribbles pseudokinase 1. (363 aa)
dusp10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (472 aa)
PAQR3Progestin and adipoQ receptor family member IIIb. (315 aa)
LOC101171428FZ domain-containing protein. (337 aa)
nox4FAD-binding FR-type domain-containing protein. (556 aa)
fzd4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (529 aa)
LOC101172593Tumor necrosis factor a (TNF superfamily, member 2). (279 aa)
LOC101171139Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (199 aa)
H2M3J6_ORYLAUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
gbaGlucosylceramidase. (522 aa)
sorl1Sortilin-related receptor, L(DLR class) A repeats containing. (2051 aa)
pik3cgPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1121 aa)
edn1Endothelin 1. (220 aa)
ern1Uncharacterized protein. (1071 aa)
LOC101162428Endoplasmic reticulum to nucleus signaling 2. (963 aa)
pdgfaPlatelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (227 aa)
tenm1Teneurin transmembrane protein 1. (2760 aa)
sfrp2Secreted frizzled-related protein 2. (290 aa)
htr2b5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (473 aa)
hgsHepatocyte growth factor-regulated tyrosine kinase substrate. (766 aa)
LOC101172518Dickkopf WNT signaling pathway inhibitor 1a. (244 aa)
LOC101161650Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (157 aa)
agtAngiotensinogen; Belongs to the serpin family. (460 aa)
axin1Axin 1. (854 aa)
Fzd8Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (573 aa)
smpd1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (604 aa)
LOC101171145Sprouty RTK signaling antagonist 2. (342 aa)
sh2b3SH2B adaptor protein 3. (724 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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