(105 nodes) Negative regulation of MAPK cascade network (Oryzias latipes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DUSP26	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (197 aa)
	PAQR3	Progestin and adipoQ receptor family member IIIb. (315 aa)
	LOC101175078	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (359 aa)
	dusp10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (472 aa)
	mecom	MDS1 and EVI1 complex locus. (1234 aa)
	LOC101159679	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (198 aa)
	bmp4	Bone morphogenetic protein 4. (441 aa)
	men1	Multiple endocrine neoplasia I. (691 aa)
	emilin1	Uncharacterized protein. (1116 aa)
	LOC101161417	Ash1 (absent, small, or homeotic)-like (Drosophila). (2905 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	spry4	Sprouty homolog 4 (Drosophila). (378 aa)
	H2L8Z5_ORYLA	DUF3496 domain-containing protein. (481 aa)
	Ankrd26	CCDC144C domain-containing protein. (283 aa)
	spred3	Sprouty related EVH1 domain containing 3. (287 aa)
	SPRED2	Sprouty related EVH1 domain containing 2. (464 aa)
	LOC101161671	Tyrosine-protein phosphatase non-receptor type. (413 aa)
	dab2	DAB adaptor protein 2. (761 aa)
	LOC101162621	Neurofibromin 2b (merlin). (604 aa)
	LOC101157459	Dual specificity phosphatase 2. (315 aa)
	phb	Prohibitin. (299 aa)
	sh2b3	SH2B adaptor protein 3. (724 aa)
	LOC101174747	Inhibitor_Mig-6 domain-containing protein. (374 aa)
	LOC101171145	Sprouty RTK signaling antagonist 2. (342 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (604 aa)
	dusp7	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
	SMAD4	Mothers against decapentaplegic homolog. (510 aa)
	agt	Angiotensinogen; Belongs to the serpin family. (460 aa)
	dusp1	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (361 aa)
	LOC105356557	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (393 aa)
	sfrp2	Secreted frizzled-related protein 2. (290 aa)
	timp3	NTR domain-containing protein. (212 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (156 aa)
	LOC101167476	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (195 aa)
	LOC101173884-2	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (209 aa)
	sorl1	Sortilin-related receptor, L(DLR class) A repeats containing. (2051 aa)
	gba	Glucosylceramidase. (522 aa)
	dact1	Dishevelled binding antagonist of beta catenin 1. (870 aa)
	qars1	Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (774 aa)
	dag1	Dystroglycan 1. (868 aa)
	LOC101171428	FZ domain-containing protein. (337 aa)
	flcn	Folliculin. (558 aa)
	LOC101168659	Dual specificity phosphatase 19a. (207 aa)
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (918 aa)
	LOC101163809	Cylindromatosis (turban tumor syndrome), b. (707 aa)
	LOC101161673	Apolipoprotein Eb. (265 aa)
	ptpn1	Tyrosine-protein phosphatase non-receptor type. (432 aa)
	H2MJT0_ORYLA	Uncharacterized protein. (589 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (198 aa)
	dusp5	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (376 aa)
	SPRY3	Sprouty RTK signaling antagonist 3. (273 aa)
	LOC101160037	Elastin microfibril interfacer 1a. (1027 aa)
	LOC100125499	3-hydroxy-3-methylglutaryl coenzyme A reductase. (865 aa)
	LOC101167759	Si:ch211-153j24.3. (371 aa)
	paqr3	Progestin and adipoQ receptor family member IIIa. (310 aa)
	fktn	Fukutin. (458 aa)
	dusp6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
	atf3	Activating transcription factor 3. (212 aa)
	Nf1	Uncharacterized protein. (506 aa)
	LOC101158780	Tyrosine-protein phosphatase non-receptor type. (405 aa)
	DUSP13	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (182 aa)
	LOC101175354	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (193 aa)
	spred1	Sprouty related EVH1 domain containing 1. (542 aa)
	efna1	Ephrin-A1b; Belongs to the ephrin family. (263 aa)
	tnip1	TNFAIP3 interacting protein 1. (650 aa)
	LOC101157048	WNK lysine deficient protein kinase 2. (2286 aa)
	LOC101167443	Si:ch211-191a24.4. (282 aa)
	LOC101173649	Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. (206 aa)
	LOC101173916	Mothers against decapentaplegic homolog. (538 aa)
	ENSORLP00000030068	Uncharacterized protein. (150 aa)
	foxm1	Fork-head domain-containing protein. (674 aa)
	tmem130	Transmembrane protein 130. (311 aa)
	vrk3	VRK serine/threonine kinase 3. (510 aa)
	c13h3orf33	C18h3orf33 homolog (H. sapiens). (267 aa)
	LOC101161900	SH3 domain containing ring finger 2. (781 aa)
	aida	Axin interactor, dorsalization associated. (305 aa)
	psmd10	Proteasome 26S subunit, non-ATPase 10. (226 aa)
	LOC101169592	Dual specificity phosphatase 19b. (208 aa)
	LOC111948169	Ephrin-A1a; Belongs to the ephrin family. (222 aa)
	LOC101167197	Si:ch211-191a24.4. (360 aa)
	LOC101166327	Si:dkey-175m17.7. (881 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1343 aa)
	LOC101174746	E3 ubiquitin-protein ligase. (877 aa)
	LOC101168449	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family. (769 aa)
	nf2	Neurofibromin 2a (merlin). (610 aa)
	LOC101165732	Peptidase S72 domain-containing protein. (901 aa)
	LOC105358735	Sprouty related EVH1 domain containing 2a. (430 aa)
	dusp27	Dual specificity phosphatase 27; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (1149 aa)
	LOC101167576	Uncharacterized protein. (943 aa)
	LOC101166888	3-hydroxy-3-methylglutaryl coenzyme A reductase. (853 aa)
	zmynd11	Zinc finger, MYND-type containing 11. (640 aa)
	LOC101163346	Bone morphogenetic protein 16. (516 aa)
	errfi1	ERBB receptor feedback inhibitor 1a. (422 aa)
	PEBP4	Phosphatidylethanolamine binding protein 4. (156 aa)
	dusp13	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (206 aa)
	LOC101167949	E3 ubiquitin-protein ligase. (879 aa)
	ash1l	Uncharacterized protein. (1977 aa)
	ENSORLP00000043858	Si:ch211-272n13.3. (250 aa)
	PRDM15	PR/SET domain 15. (1119 aa)
	LOC101166399	Apolipoprotein Ea. (262 aa)
	LOC101163504	Mothers against decapentaplegic homolog. (528 aa)
	cdk5rap3	CDK5 regulatory subunit associated protein 3. (500 aa)
	ENSORLP00000045591	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (130 aa)
	prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (466 aa)
	dusp4	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (372 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ankrd26	ENSORLP00000043858	ENSORLP00000002329	ENSORLP00000043858	CCDC144C domain-containing protein.	Si:ch211-272n13.3.	0.893
Ankrd26	H2L8Z5_ORYLA	ENSORLP00000002329	ENSORLP00000002328	CCDC144C domain-containing protein.	DUF3496 domain-containing protein.	0.880
DUSP13	vrk3	ENSORLP00000026413	ENSORLP00000030866	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	VRK serine/threonine kinase 3.	0.491
DUSP26	vrk3	ENSORLP00000043178	ENSORLP00000030866	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	VRK serine/threonine kinase 3.	0.491
ENSORLP00000030068	H2MJT0_ORYLA	ENSORLP00000030068	ENSORLP00000018929	Uncharacterized protein.	Uncharacterized protein.	0.612
ENSORLP00000030068	Nf1	ENSORLP00000030068	ENSORLP00000026133	Uncharacterized protein.	Uncharacterized protein.	0.612
ENSORLP00000030068	spred3	ENSORLP00000030068	ENSORLP00000002839	Uncharacterized protein.	Sprouty related EVH1 domain containing 3.	0.917
ENSORLP00000043858	Ankrd26	ENSORLP00000043858	ENSORLP00000002329	Si:ch211-272n13.3.	CCDC144C domain-containing protein.	0.893
ENSORLP00000043858	H2L8Z5_ORYLA	ENSORLP00000043858	ENSORLP00000002328	Si:ch211-272n13.3.	DUF3496 domain-containing protein.	0.825
ENSORLP00000045591	LOC101165732	ENSORLP00000045591	ENSORLP00000037673	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Peptidase S72 domain-containing protein.	0.484
ENSORLP00000045591	cav3	ENSORLP00000045591	ENSORLP00000000896	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.555
ENSORLP00000045591	dag1	ENSORLP00000045591	ENSORLP00000013717	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Dystroglycan 1.	0.484
ENSORLP00000045591	sfrp2	ENSORLP00000045591	ENSORLP00000010461	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Secreted frizzled-related protein 2.	0.498
H2L8Z5_ORYLA	Ankrd26	ENSORLP00000002328	ENSORLP00000002329	DUF3496 domain-containing protein.	CCDC144C domain-containing protein.	0.880
H2L8Z5_ORYLA	ENSORLP00000043858	ENSORLP00000002328	ENSORLP00000043858	DUF3496 domain-containing protein.	Si:ch211-272n13.3.	0.825
H2MJT0_ORYLA	ENSORLP00000030068	ENSORLP00000018929	ENSORLP00000030068	Uncharacterized protein.	Uncharacterized protein.	0.612
H2MJT0_ORYLA	LOC105358735	ENSORLP00000018929	ENSORLP00000038410	Uncharacterized protein.	Sprouty related EVH1 domain containing 2a.	0.822
H2MJT0_ORYLA	Nf1	ENSORLP00000018929	ENSORLP00000026133	Uncharacterized protein.	Uncharacterized protein.	0.943
H2MJT0_ORYLA	SPRED2	ENSORLP00000018929	ENSORLP00000003022	Uncharacterized protein.	Sprouty related EVH1 domain containing 2.	0.822
H2MJT0_ORYLA	spred1	ENSORLP00000018929	ENSORLP00000028048	Uncharacterized protein.	Sprouty related EVH1 domain containing 1.	0.834