(98 nodes) Mitotic DNA damage checkpoint signaling network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSORLP00000031910	Uncharacterized protein. (93 aa)
	ENSORLP00000031965	Reverse transcriptase domain-containing protein. (1239 aa)
	mfsd11	Major facilitator superfamily domain containing 11. (450 aa)
	ENSORLP00000032456	Reverse transcriptase domain-containing protein. (1248 aa)
	ENSORLP00000032655	Reverse transcriptase domain-containing protein. (1262 aa)
	ENSORLP00000032709	Reverse transcriptase domain-containing protein. (444 aa)
	chek2	Checkpoint kinase 2. (526 aa)
	ENSORLP00000032954	Reverse transcriptase domain-containing protein. (1115 aa)
	ENSORLP00000034014	Reverse transcriptase domain-containing protein. (1314 aa)
	ENSORLP00000034031	Reverse transcriptase domain-containing protein. (1278 aa)
	ENSORLP00000034408	Reverse transcriptase domain-containing protein. (961 aa)
	ENSORLP00000034792	Reverse transcriptase domain-containing protein. (845 aa)
	ENSORLP00000035462	Reverse transcriptase domain-containing protein. (855 aa)
	ENSORLP00000035982	Reverse transcriptase domain-containing protein. (1283 aa)
	ENSORLP00000036064	Reverse transcriptase domain-containing protein. (1025 aa)
	ENSORLP00000036193	Reverse transcriptase domain-containing protein. (1249 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (656 aa)
	ENSORLP00000037118	annotation not available (1248 aa)
	ENSORLP00000037248	Reverse transcriptase domain-containing protein. (938 aa)
	ENSORLP00000037357	Reverse transcriptase domain-containing protein. (1203 aa)
	ENSORLP00000037560	Reverse transcriptase domain-containing protein. (772 aa)
	ENSORLP00000037569	Reverse transcriptase domain-containing protein. (1153 aa)
	ENSORLP00000037754	Reverse transcriptase domain-containing protein. (923 aa)
	hus1	Checkpoint protein; Belongs to the HUS1 family. (299 aa)
	ENSORLP00000039392	Reverse transcriptase domain-containing protein. (1262 aa)
	uimc1	Uncharacterized protein. (838 aa)
	ENSORLP00000040440	Reverse transcriptase domain-containing protein. (1236 aa)
	xpc	Xeroderma pigmentosum, complementation group C. (925 aa)
	ENSORLP00000041309	Reverse transcriptase domain-containing protein. (800 aa)
	ENSORLP00000041457	Reverse transcriptase domain-containing protein. (891 aa)
	ENSORLP00000041938	Reverse transcriptase domain-containing protein. (1249 aa)
	ENSORLP00000042234	Reverse transcriptase domain-containing protein. (1248 aa)
	LOC101172571	FA complementation group D2. (1518 aa)
	ENSORLP00000043225	Reverse transcriptase domain-containing protein. (968 aa)
	ENSORLP00000043737	Reverse transcriptase domain-containing protein. (1243 aa)
	ENSORLP00000043739	Reverse transcriptase domain-containing protein. (805 aa)
	ENSORLP00000044186	Reverse transcriptase domain-containing protein. (1243 aa)
	LOC101155230	Protein kinase domain-containing protein. (1255 aa)
	rad9b	RAD9 checkpoint clamp component B. (402 aa)
	abraxas1	Abraxas 1, BRCA1 A complex subunit. (387 aa)
	cdk5rap3	CDK5 regulatory subunit associated protein 3. (500 aa)
	ENSORLP00000045767	Reverse transcriptase domain-containing protein. (1239 aa)
	LOC101169236	WW domain-containing protein. (544 aa)
	ENSORLP00000027785	Reverse transcriptase domain-containing protein. (902 aa)
	ENSORLP00000027695	Reverse transcriptase domain-containing protein. (1076 aa)
	ENSORLP00000027619	TAN domain-containing protein. (321 aa)
	ENSORLP00000027276	Reverse transcriptase domain-containing protein. (1441 aa)
	ENSORLP00000027128	Reverse transcriptase domain-containing protein. (851 aa)
	blm	Uncharacterized protein. (1393 aa)
	ENSORLP00000026921	Reverse transcriptase domain-containing protein. (1102 aa)
	Atm	Uncharacterized protein. (147 aa)
	donson	Uncharacterized protein. (596 aa)
	cdk1	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C- terminus of RNA polymerase II. Catalytic component of MPF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (303 aa)
	LOC101164618	CASP2 and RIPK1 domain containing adaptor with death domain. (203 aa)
	tipin	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (311 aa)
	babam2	BRISC and BRCA1 A complex member 2. (386 aa)
	cdca7	Cell division cycle associated 7a. (391 aa)
	ZNF830	Zinc finger protein 830. (324 aa)
	H2MR50_ORYLA	Uncharacterized protein. (156 aa)
	FZR1	Fizzy/cell division cycle 20 related 1a. (498 aa)
	Brcc3	BRCA1/BRCA2-containing complex, subunit 3. (296 aa)
	eme1	Essential meiotic structure-specific endonuclease 1. (459 aa)
	rint1	RAD50 interactor 1. (780 aa)
	topbp1	DNA topoisomerase II binding protein 1. (1460 aa)
	dtl	Denticleless E3 ubiquitin protein ligase homolog (Drosophila). (646 aa)
	casp2	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (501 aa)
	foxn3	Checkpoint suppressor 1. (478 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
	LOC101174862	Fizzy/cell division cycle 20 related 1b. (492 aa)
	CLSPN	Claspin. (1282 aa)
	babam1	BRISC and BRCA1 A complex member 1. (377 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (450 aa)
	LOC101160676	TAO kinase 3b. (379 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (694 aa)
	LOC101168864	P53-induced death domain protein 1. (1004 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (454 aa)
	prkdc	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3962 aa)
	LOC101166893	Protein kinase domain-containing protein. (943 aa)
	LOC101171668	Uncharacterized protein. (446 aa)
	brca1	Uncharacterized protein. (1292 aa)
	wac	WW domain containing adaptor with coiled-coil a. (544 aa)
	CDCA7L	zf-4CXXC_R1 domain-containing protein. (414 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (388 aa)
	LOC101163990	Protein kinase domain-containing protein. (1015 aa)
	ticrr	Treslin_N domain-containing protein. (1831 aa)
	taok3	TAO kinase 3a. (900 aa)
	rfwd3	Ring finger and WD repeat domain 3. (702 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	LOC101169206	TAO kinase 2a. (1139 aa)
	ENSORLP00000028101	Reverse transcriptase domain-containing protein. (1240 aa)
	ENSORLP00000028253	Reverse transcriptase domain-containing protein. (1038 aa)
	EME2	ERCC4 domain-containing protein. (443 aa)
	ENSORLP00000028582	Reverse transcriptase domain-containing protein. (1003 aa)
	ENSORLP00000029266	Reverse transcriptase domain-containing protein. (1253 aa)
	ENSORLP00000029565	Reverse transcriptase domain-containing protein. (925 aa)
	ENSORLP00000030024	Reverse transcriptase domain-containing protein. (1000 aa)
	fbxo31	F-box protein 31. (585 aa)
	ENSORLP00000031530	Reverse transcriptase domain-containing protein. (1095 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atm	Brcc3	ENSORLP00000026266	ENSORLP00000018748	Uncharacterized protein.	BRCA1/BRCA2-containing complex, subunit 3.	0.576
Atm	CDCA7L	ENSORLP00000026266	ENSORLP00000004925	Uncharacterized protein.	zf-4CXXC_R1 domain-containing protein.	0.742
Atm	CLSPN	ENSORLP00000026266	ENSORLP00000012274	Uncharacterized protein.	Claspin.	0.470
Atm	ENSORLP00000027619	ENSORLP00000026266	ENSORLP00000027619	Uncharacterized protein.	TAN domain-containing protein.	0.929
Atm	LOC101168864	ENSORLP00000026266	ENSORLP00000007907	Uncharacterized protein.	P53-induced death domain protein 1.	0.661
Atm	LOC101172571	ENSORLP00000026266	ENSORLP00000042398	Uncharacterized protein.	FA complementation group D2.	0.609
Atm	babam1	ENSORLP00000026266	ENSORLP00000011165	Uncharacterized protein.	BRISC and BRCA1 A complex member 1.	0.561
Atm	babam2	ENSORLP00000026266	ENSORLP00000022800	Uncharacterized protein.	BRISC and BRCA1 A complex member 2.	0.618
Atm	blm	ENSORLP00000026266	ENSORLP00000027048	Uncharacterized protein.	Uncharacterized protein.	0.890
Atm	brca1	ENSORLP00000026266	ENSORLP00000005763	Uncharacterized protein.	Uncharacterized protein.	0.993
Atm	cdca7	ENSORLP00000026266	ENSORLP00000021845	Uncharacterized protein.	Cell division cycle associated 7a.	0.742
Atm	cdk1	ENSORLP00000026266	ENSORLP00000024000	Uncharacterized protein.	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C- terminus of RNA polymerase II. Catalytic component of MPF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	0.562
Atm	chek1	ENSORLP00000026266	ENSORLP00000007199	Uncharacterized protein.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.977
Atm	chek2	ENSORLP00000026266	ENSORLP00000032936	Uncharacterized protein.	Checkpoint kinase 2.	0.993
Atm	eme1	ENSORLP00000026266	ENSORLP00000018481	Uncharacterized protein.	Essential meiotic structure-specific endonuclease 1.	0.594
Atm	hus1	ENSORLP00000026266	ENSORLP00000039054	Uncharacterized protein.	Checkpoint protein; Belongs to the HUS1 family.	0.773
Atm	mre11	ENSORLP00000026266	ENSORLP00000009106	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.997
Atm	msh2	ENSORLP00000026266	ENSORLP00000012873	Uncharacterized protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.674
Atm	mus81	ENSORLP00000026266	ENSORLP00000036282	Uncharacterized protein.	MUS81 structure-specific endonuclease subunit.	0.717
Atm	prkdc	ENSORLP00000026266	ENSORLP00000006867	Uncharacterized protein.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.687