(136 nodes) Membrane raft network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101163128	TIR domain-containing protein; Belongs to the Toll-like receptor family. (826 aa)
	LOC100125525	Uncharacterized protein. (455 aa)
	stom	Stomatin. (284 aa)
	LOC101159590	Platelet/endothelial cell adhesion molecule 1. (793 aa)
	tnfrsf1a	Tumor necrosis factor receptor superfamily, member 1a. (385 aa)
	slc1a2	Amino acid transporter. (526 aa)
	LOC101167158	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family. (430 aa)
	flot2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (432 aa)
	dag1	Dystroglycan 1. (868 aa)
	LOC101172593	Tumor necrosis factor a (TNF superfamily, member 2). (279 aa)
	LOC101168044	Uncharacterized protein. (283 aa)
	LOC101165720	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1110 aa)
	LOC101157726	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (465 aa)
	LOC111948766	Uncharacterized protein. (294 aa)
	card11	Caspase recruitment domain family, member 11. (1146 aa)
	lipe	Lipase, hormone-sensitive b. (862 aa)
	LOC101162414	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1011 aa)
	slc6a4	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (671 aa)
	htr2a	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a. (487 aa)
	plpp2	Phospholipid phosphatase 2a. (292 aa)
	serpinh1	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b; Belongs to the serpin family. (445 aa)
	LOC101156206	Caveolae associated protein 1b. (469 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (828 aa)
	LOC101174546	Uncharacterized protein. (308 aa)
	LOC101163758	Uncharacterized protein. (852 aa)
	LOC101160323	E3 ubiquitin-protein ligase. (770 aa)
	inpp5d	Inositol polyphosphate-5-phosphatase D. (1092 aa)
	LOC101155381	Toll-like receptor 18. (873 aa)
	cd36	CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (466 aa)
	mlc1	Modulator of VRAC current 1. (393 aa)
	rftn1	Uncharacterized protein. (616 aa)
	cln3	Battenin. (437 aa)
	aqp1	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (261 aa)
	lamtor3	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (132 aa)
	stoml2	Stomatin (EPB72)-like 2. (355 aa)
	cavin2	Uncharacterized protein. (392 aa)
	emp2	Epithelial membrane protein 2. (165 aa)
	il6st	Uncharacterized protein. (868 aa)
	lamtor4	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (101 aa)
	LOC101162818	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
	pikfyve	Phosphoinositide kinase, FYVE finger containing. (2070 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2241 aa)
	psen2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (421 aa)
	asah2	Neutral ceramidase. (729 aa)
	plpp3	Phospholipid phosphatase 3. (332 aa)
	pllp	Plasmolipin. (178 aa)
	LOC101166500	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
	ripk1	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (675 aa)
	LOC101164252	Caveolae associated protein 4a. (330 aa)
	cblb	Cbl proto-oncogene B, E3 ubiquitin protein ligase. (906 aa)
	LOC101171943	acidPPc domain-containing protein. (355 aa)
	scarb1	Scavenger receptor class B, member 1; Belongs to the CD36 family. (532 aa)
	ret	Ret proto-oncogene receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1144 aa)
	LOC101169731	Si:dkeyp-66d1.7. (293 aa)
	LOC105355770	Mal, T cell differentiation protein. (220 aa)
	ENSORLP00000029637	Uncharacterized protein. (323 aa)
	cavin2-2	Caveolae associated protein 2a. (591 aa)
	rtn4rl1	Reticulon 4 receptor-like 1b. (474 aa)
	LOC101167793	Zgc:77748. (283 aa)
	mal2	Mal, T cell differentiation protein 2 (gene/pseudogene). (182 aa)
	bves	Blood vessel epicardial substance. (356 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1231 aa)
	slc6a2	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (625 aa)
	LOC101156574	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (189 aa)
	ENSORLP00000033307	Uncharacterized protein. (126 aa)
	LOC101166715	Uncharacterized protein; Belongs to the potassium channel family. (719 aa)
	LOC101167634	Coagulation factor II thrombin receptor. (440 aa)
	SMURF2	E3 ubiquitin-protein ligase. (795 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1343 aa)
	LOC101169488	Transient receptor potential cation channel, subfamily C, member 5a; Belongs to the transient receptor (TC 1.A.4) family. (1089 aa)
	p2rx3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
	ENSORLP00000037049	Guanylate cyclase domain-containing protein. (171 aa)
	LOC101156966	Phospholipid phosphatase 2b. (286 aa)
	LOC101155876	Mal, T cell differentiation protein b. (152 aa)
	LOC101165732	Peptidase S72 domain-containing protein. (901 aa)
	rtn4r	Reticulon 4 receptor. (488 aa)
	fas	Uncharacterized protein. (310 aa)
	vdac1	Voltage-dependent anion channel 1. (299 aa)
	LOC101171872	ADAM metallopeptidase domain 17a. (850 aa)
	akap6	A kinase (PRKA) anchor protein 6. (2292 aa)
	LOC110014685	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (219 aa)
	neu3	Sialidase 3a. (410 aa)
	LOC101167335	BAALC binder of MAP3K1 and KLF4 b. (181 aa)
	lamtor2	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (190 aa)
	LOC101154885	Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (926 aa)
	STOML3	Stomatin (EPB72)-like 3a. (288 aa)
	LOC101174785	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (587 aa)
	unc5a	Unc-5 netrin receptor A. (903 aa)
	cd79a	CD79a molecule, immunoglobulin-associated alpha. (220 aa)
	cln6	CLN6 transmembrane ER protein a. (310 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
	LOC101163275	Plasmalemma vesicle associated protein a. (573 aa)
	LOC101164882	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (237 aa)
	lamtor1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (160 aa)
	cavin1	Caveolae associated protein 1a. (420 aa)
	smurf1	E3 ubiquitin-protein ligase. (728 aa)
	LOC101165277	ADAM metallopeptidase domain 17b. (844 aa)
	LOC101165777	Podocalyxin-like. (419 aa)
	LOC101161541	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (695 aa)
	LOC101166652	Reticulon 4 receptor-like 1a. (455 aa)
	pag1	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (452 aa)
	LOC101158476	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (557 aa)
	LOC101154844	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (410 aa)
	ENSORLP00000045591	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (130 aa)
	plvap	Plasmalemma vesicle associated protein b. (424 aa)
	ppt1	Palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile). (304 aa)
	LOC101160745	Lipase, hormone-sensitive a. (705 aa)
	LOC101164130	ATP-binding cassette, sub-family G (WHITE), member 2c. (618 aa)
	LOC101166708	NPHS2 stomatin family member, podocin. (356 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (946 aa)
	LOC101156825	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (579 aa)
	LOC101161346	Uncharacterized protein. (355 aa)
	LOC101170649	ATP-binding cassette, sub-family G (WHITE), member 2d. (667 aa)
	LOC101155616	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (424 aa)
	smpd2	Sphingomyelin phosphodiesterase 2b, neutral membrane (neutral sphingomyelinase). (442 aa)
	lamtor5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (91 aa)
	KIF18A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (915 aa)
	plpp1	Phospholipid phosphatase 1a. (282 aa)
	slc6a3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (623 aa)
	LOC101162729	Stomatin (EPB72)-like 3b. (274 aa)
	LOC101173000	Stomatin (EPB72)-like 3b. (270 aa)
	LOC101174929	Toll-like receptor 1; Belongs to the Toll-like receptor family. (795 aa)
	park7	DJ-1. (189 aa)
	trpc4	Transient receptor potential cation channel, subfamily C, member 4a; Belongs to the transient receptor (TC 1.A.4) family. (976 aa)
	LOC101156113	Mal, T cell differentiation protein. (153 aa)
	LOC101159828	acidPPc domain-containing protein. (286 aa)
	LOC101159866	Caveolae associated protein 4b. (301 aa)
	LOC101170152	Mal, T cell differentiation protein a. (155 aa)
	LOC101167488	ATP-binding cassette, sub-family G (WHITE), member 2a. (654 aa)
	LOC101162959	TIR domain-containing protein. (831 aa)
	LOC101164911	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
	LOC101156223	Si:dkey-237i9.8. (782 aa)
	LOC101167791	Amino acid transporter. (663 aa)
	H2L6E1_ORYLA	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (364 aa)
	LOC101160301	Amino acid transporter. (527 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000033307	LOC101161541	ENSORLP00000033307	ENSORLP00000043809	Uncharacterized protein.	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family.	0.978
ENSORLP00000033307	LOC101166715	ENSORLP00000033307	ENSORLP00000034183	Uncharacterized protein.	Uncharacterized protein; Belongs to the potassium channel family.	0.978
ENSORLP00000037049	H2L6E1_ORYLA	ENSORLP00000037049	ENSORLP00000001388	Guanylate cyclase domain-containing protein.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.531
ENSORLP00000037049	LOC101165720	ENSORLP00000037049	ENSORLP00000016126	Guanylate cyclase domain-containing protein.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.435
ENSORLP00000037049	LOC101166500	ENSORLP00000037049	ENSORLP00000026434	Guanylate cyclase domain-containing protein.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.434
ENSORLP00000045591	LOC100125525	ENSORLP00000045591	ENSORLP00000015999	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.508
ENSORLP00000045591	LOC101155616	ENSORLP00000045591	ENSORLP00000008720	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.738
ENSORLP00000045591	LOC101156206	ENSORLP00000045591	ENSORLP00000017990	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolae associated protein 1b.	0.722
ENSORLP00000045591	LOC101157726	ENSORLP00000045591	ENSORLP00000016266	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.730
ENSORLP00000045591	LOC101162729	ENSORLP00000045591	ENSORLP00000005958	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Stomatin (EPB72)-like 3b.	0.447
ENSORLP00000045591	LOC101162818	ENSORLP00000045591	ENSORLP00000024539	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.555
ENSORLP00000045591	LOC101164911	ENSORLP00000045591	ENSORLP00000002427	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.491
ENSORLP00000045591	LOC101165732	ENSORLP00000045591	ENSORLP00000037673	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Peptidase S72 domain-containing protein.	0.484
ENSORLP00000045591	LOC101173000	ENSORLP00000045591	ENSORLP00000005956	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Stomatin (EPB72)-like 3b.	0.447
ENSORLP00000045591	LOC110014685	ENSORLP00000045591	ENSORLP00000040165	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.973
ENSORLP00000045591	STOML3	ENSORLP00000045591	ENSORLP00000041321	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Stomatin (EPB72)-like 3a.	0.447
ENSORLP00000045591	cav3	ENSORLP00000045591	ENSORLP00000000896	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.555
ENSORLP00000045591	cavin1	ENSORLP00000045591	ENSORLP00000042915	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolae associated protein 1a.	0.722
ENSORLP00000045591	dag1	ENSORLP00000045591	ENSORLP00000013717	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Dystroglycan 1.	0.484
ENSORLP00000045591	flot2	ENSORLP00000045591	ENSORLP00000014302	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.491