(29 nodes) Response to ethanol network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ogg1	8-oxoguanine DNA glycosylase. (395 aa)
	LOC101174852	Glycine receptor, alpha 4b; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (479 aa)
	LOC101175080	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1430 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (291 aa)
	LOC101168687	Zgc:153993. (293 aa)
	LOC101174559	Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (585 aa)
	LOC101167323	Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (252 aa)
	Unc79	Uncharacterized protein. (152 aa)
	SLC10A1	Solute carrier family 10 member 1. (338 aa)
	bad	BCL2 associated agonist of cell death b. (164 aa)
	Cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (109 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	LOC101156095	Glycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (455 aa)
	LOC101166566	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	crhbp	Corticotropin releasing hormone binding protein. (319 aa)
	LOC101156980	Uncharacterized protein. (356 aa)
	psmd14	Proteasome 26S subunit, non-ATPase 14. (325 aa)
	nr0b2	Nuclear receptor subfamily 0, group B, member 2a. (280 aa)
	LOC101156528	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (212 aa)
	dmap1	DNA methyltransferase 1 associated protein 1. (484 aa)
	tbxa2r	Thromboxane A2 receptor. (352 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1216 aa)
	LOC101167573	Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (184 aa)
	glra2	Glycine receptor, alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (453 aa)
	fgfr1	Fibroblast growth factor receptor. (833 aa)
	tufm	Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (446 aa)
	glra1	Glycine receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (464 aa)
	ache	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (619 aa)
	LOC101169010	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (608 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cldn5	LOC101156528	ENSORLP00000026956	ENSORLP00000005747	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.757
Cldn5	LOC101166566	ENSORLP00000026956	ENSORLP00000001336	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
LOC101156528	Cldn5	ENSORLP00000005747	ENSORLP00000026956	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.757
LOC101156528	LOC101166566	ENSORLP00000005747	ENSORLP00000001336	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.781
LOC101166566	Cldn5	ENSORLP00000001336	ENSORLP00000026956	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
LOC101166566	LOC101156528	ENSORLP00000001336	ENSORLP00000005747	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.781
LOC101168687	bad	ENSORLP00000040142	ENSORLP00000030079	Zgc:153993.	BCL2 associated agonist of cell death b.	0.869
SLC10A1	fgf19	ENSORLP00000031015	ENSORLP00000000352	Solute carrier family 10 member 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.460
SLC10A1	nr0b2	ENSORLP00000031015	ENSORLP00000005570	Solute carrier family 10 member 1.	Nuclear receptor subfamily 0, group B, member 2a.	0.571
bad	LOC101168687	ENSORLP00000030079	ENSORLP00000040142	BCL2 associated agonist of cell death b.	Zgc:153993.	0.869
fgf19	SLC10A1	ENSORLP00000000352	ENSORLP00000031015	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Solute carrier family 10 member 1.	0.460
fgf19	fgfr1	ENSORLP00000000352	ENSORLP00000017825	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.896
fgf19	nr0b2	ENSORLP00000000352	ENSORLP00000005570	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Nuclear receptor subfamily 0, group B, member 2a.	0.574
fgfr1	fgf19	ENSORLP00000017825	ENSORLP00000000352	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.896
nr0b2	SLC10A1	ENSORLP00000005570	ENSORLP00000031015	Nuclear receptor subfamily 0, group B, member 2a.	Solute carrier family 10 member 1.	0.571
nr0b2	fgf19	ENSORLP00000005570	ENSORLP00000000352	Nuclear receptor subfamily 0, group B, member 2a.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.574