(61 nodes) Regulation of T cell differentiation network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	lag3	Uncharacterized protein. (472 aa)
	sh3rf1	SH3 domain containing ring finger 1. (880 aa)
	H2L4N6_ORYLA	Uncharacterized protein. (780 aa)
	H2L4S9_ORYLA	Fibrinogen C-terminal domain-containing protein. (213 aa)
	LOC101163430	Interferon regulatory factor. (293 aa)
	sash3	SAM and SH3 domain containing 3. (391 aa)
	LOC101157631	Transforming growth factor beta; Belongs to the TGF-beta family. (444 aa)
	kat2a	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (810 aa)
	LOC101174272-2	PRELI domain containing 1a. (210 aa)
	nfkbid	ANK_REP_REGION domain-containing protein. (453 aa)
	lef1	Lymphoid enhancer-binding factor 1. (379 aa)
	mettl3	Methyltransferase like 3; Belongs to the MT-A70-like family. (584 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (590 aa)
	tmem131l	Transmembrane 131 like. (1513 aa)
	sos2	Son of sevenless homolog 2 (Drosophila). (1323 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (270 aa)
	LOC101170530	Ring finger and CCCH-type domains 2. (1143 aa)
	slc46a2	Solute carrier family 46 member 2. (446 aa)
	dusp10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (472 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (387 aa)
	prdm1b	Prdm1b. (775 aa)
	H2ME57_ORYLA	V-set immunoregulatory receptor. (288 aa)
	card11	Caspase recruitment domain family, member 11. (1146 aa)
	ambra1	Autophagy/beclin-1 regulator 1b. (1376 aa)
	LOC101170545	Zinc finger CCCH-type containing 12A. (621 aa)
	cd83	Ig-like domain-containing protein. (223 aa)
	prdm1	Prdm1a. (845 aa)
	zbtb1	Zinc finger and BTB domain containing 1. (684 aa)
	LOC101158138	Ring finger and CCCH-type domains 1b. (1116 aa)
	myb	Uncharacterized protein. (592 aa)
	gata3	Uncharacterized protein. (440 aa)
	LOC101173598	Si:ch211-203k16.3. (340 aa)
	LOC101173752	IGv domain-containing protein. (224 aa)
	ENSORLP00000025959	PR domain containing 1b, with ZNF domain. (606 aa)
	sos1	Son of sevenless homolog 1 (Drosophila). (1297 aa)
	xbp1	X-box binding protein 1. (259 aa)
	LOC101170171	Zeta chain of T cell receptor associated protein kinase 70. (668 aa)
	bad	BCL2 associated agonist of cell death b. (164 aa)
	LOC101160820	SCY domain-containing protein. (131 aa)
	ENSORLP00000030535	Fibronectin type-III domain-containing protein. (383 aa)
	drosha	Drosha ribonuclease III. (1317 aa)
	fgl2	Fibrinogen-like 2a. (496 aa)
	tbx21	T-box transcription factor 21. (619 aa)
	SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (763 aa)
	LOC101164954	PRELI/MSF1 domain-containing protein. (221 aa)
	LOC101166327	Si:dkey-175m17.7. (881 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1343 aa)
	LOC100125524	Forkhead box N1. (574 aa)
	syk	Tyrosine-protein kinase. (624 aa)
	tcf7	Transcription factor 7. (536 aa)
	LOC101158686	MALT paracaspase 2. (843 aa)
	ENSORLP00000039947	Ig-like domain-containing protein. (361 aa)
	LOC101171157	Si:ch211-157b11.8. (423 aa)
	LOC101158194	MALT paracaspase 3. (557 aa)
	LOC101162039	KRAP_IP3R_bind domain-containing protein. (667 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
	LOC101172571	FA complementation group D2. (1518 aa)
	socs1	Suppressor of cytokine signaling 1. (199 aa)
	cbfb	Core-binding factor subunit beta. (188 aa)
	LOC101171170	MALT paracaspase 1. (811 aa)
	ENSORLP00000045949	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta. (274 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000030535	lag3	ENSORLP00000030535	ENSORLP00000034716	Fibronectin type-III domain-containing protein.	Uncharacterized protein.	0.407
ENSORLP00000030535	ptprc	ENSORLP00000030535	ENSORLP00000035490	Fibronectin type-III domain-containing protein.	Protein tyrosine phosphatase receptor type C.	0.668
ENSORLP00000030535	tbx21	ENSORLP00000030535	ENSORLP00000032374	Fibronectin type-III domain-containing protein.	T-box transcription factor 21.	0.408
ENSORLP00000045949	LOC101163430	ENSORLP00000045949	ENSORLP00000001396	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta.	Interferon regulatory factor.	0.486
ENSORLP00000045949	LOC101170545	ENSORLP00000045949	ENSORLP00000018100	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta.	Zinc finger CCCH-type containing 12A.	0.423
ENSORLP00000045949	ZC3H12A	ENSORLP00000045949	ENSORLP00000011872	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta.	Zinc finger CCCH-type containing 12A.	0.423
ENSORLP00000045949	socs1	ENSORLP00000045949	ENSORLP00000042740	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta.	Suppressor of cytokine signaling 1.	0.499
H2L4N6_ORYLA	ripk2	ENSORLP00000000732	ENSORLP00000010554	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 2.	0.435
LOC100125524	LOC101170171	ENSORLP00000036050	ENSORLP00000028913	Forkhead box N1.	Zeta chain of T cell receptor associated protein kinase 70.	0.419
LOC100125524	gata3	ENSORLP00000036050	ENSORLP00000021422	Forkhead box N1.	Uncharacterized protein.	0.470
LOC100125524	myb	ENSORLP00000036050	ENSORLP00000020749	Forkhead box N1.	Uncharacterized protein.	0.472
LOC101157631	TGFBR2	ENSORLP00000001563	ENSORLP00000041955	Transforming growth factor beta; Belongs to the TGF-beta family.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.998
LOC101157631	cbfb	ENSORLP00000001563	ENSORLP00000044119	Transforming growth factor beta; Belongs to the TGF-beta family.	Core-binding factor subunit beta.	0.479
LOC101158138	LOC101170530	ENSORLP00000020077	ENSORLP00000012569	Ring finger and CCCH-type domains 1b.	Ring finger and CCCH-type domains 2.	0.673
LOC101158194	card11	ENSORLP00000040489	ENSORLP00000016969	MALT paracaspase 3.	Caspase recruitment domain family, member 11.	0.865
LOC101158686	card11	ENSORLP00000039932	ENSORLP00000016969	MALT paracaspase 2.	Caspase recruitment domain family, member 11.	0.865
LOC101160820	ptprc	ENSORLP00000030164	ENSORLP00000035490	SCY domain-containing protein.	Protein tyrosine phosphatase receptor type C.	0.445
LOC101162039	tcf7	ENSORLP00000041127	ENSORLP00000037664	KRAP_IP3R_bind domain-containing protein.	Transcription factor 7.	0.559
LOC101163430	ENSORLP00000045949	ENSORLP00000001396	ENSORLP00000045949	Interferon regulatory factor.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta.	0.486
LOC101163430	ptprc	ENSORLP00000001396	ENSORLP00000035490	Interferon regulatory factor.	Protein tyrosine phosphatase receptor type C.	0.413