74 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2L3P1_ORYLA	Extracellular matrix protein 1a. (122 aa)
	emilin1	Uncharacterized protein. (1116 aa)
	LOC101159216	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (527 aa)
	LOC101174288	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (781 aa)
	Fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (159 aa)
	utp15	UTP15 small subunit processome component. (528 aa)
	vegfc	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (494 aa)
	MTDH	Uncharacterized protein. (537 aa)
	LOC101162456	Si:ch73-380n15.2. (560 aa)
	itgb8	Integrin beta; Belongs to the integrin beta chain family. (745 aa)
	f3	Coagulation factor IIIa. (284 aa)
	brca1	Uncharacterized protein. (1292 aa)
	LOC101161650	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (157 aa)
	tbxa2r	Thromboxane A2 receptor. (352 aa)
	cd34	Uncharacterized protein. (328 aa)
	LOC101166150	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (198 aa)
	LOC101164095	Uncharacterized protein. (286 aa)
	sfrp2	Secreted frizzled-related protein 2. (290 aa)
	H2LZ22_ORYLA	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (270 aa)
	LOC101172843	Uncharacterized protein. (543 aa)
	LOC101155633	Uncharacterized protein. (617 aa)
	angptl3	Angiopoietin-like 3. (472 aa)
	serpine1	SERPIN domain-containing protein; Belongs to the serpin family. (447 aa)
	tie1	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1. (1133 aa)
	DDAH1	Dimethylarginine dimethylaminohydrolase 1. (283 aa)
	LOC101171428	FZ domain-containing protein. (337 aa)
	emilin2	Elastin microfibril interfacer 2b. (977 aa)
	am3	Adrenomedullin 3. (168 aa)
	LOC101173369	Junction plakoglobin a. (733 aa)
	H2MBJ4_ORYLA	Uncharacterized protein. (306 aa)
	LOC101157704	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	LOC101155796	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (680 aa)
	sash1	SAM and SH3 domain containing 1a. (1225 aa)
	LOC101167346	Uncharacterized protein. (527 aa)
	LOC101170545	Zinc finger CCCH-type containing 12A. (621 aa)
	sirt6	Sirtuin 6. (347 aa)
	bmper	BMP binding endothelial regulator. (683 aa)
	LOC101158525	Rap guanine nucleotide exchange factor (GEF) 3. (798 aa)
	il10	Interleukin 10. (181 aa)
	LOC101160037	Elastin microfibril interfacer 1a. (1027 aa)
	tnn	Tenascin N. (834 aa)
	aggf1	Angiogenic factor with G patch and FHA domains 1. (785 aa)
	H2MR15_ORYLA	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (514 aa)
	c5	Uncharacterized protein. (1211 aa)
	nfe2l2	Nuclear factor, erythroid 2-like 2a. (605 aa)
	aqp1	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (261 aa)
	LOC101168927	Uncharacterized protein. (519 aa)
	xbp1	X-box binding protein 1. (259 aa)
	ctsh	Cathepsin H; Belongs to the peptidase C1 family. (324 aa)
	CXCR3	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (382 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	ENSORLP00000031846	Uncharacterized protein. (54 aa)
	btg1	B-cell translocation gene 1, anti-proliferative. (182 aa)
	LOC100301586	CD40 molecule, TNF receptor superfamily member 5. (305 aa)
	LOC101156279	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	LOC101161449	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (135 aa)
	sp1	Sp1 transcription factor. (467 aa)
	LOC101160921	Si:ch211-39a7.1. (616 aa)
	LOC101166204	Uncharacterized protein. (534 aa)
	ENSORLP00000036607	Uncharacterized protein. (251 aa)
	LOC101169209	Uncharacterized protein. (283 aa)
	vegfb	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (237 aa)
	fgf18	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	LOC101155422	Uncharacterized protein. (115 aa)
	LOC101157091	PH domain-containing protein. (761 aa)
	LOC101158865	Dimethylarginine dimethylaminohydrolase 2. (290 aa)
	gab1	GRB2-associated binding protein 1. (795 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
	s100a1	Protein S100; Belongs to the S-100 family. (99 aa)
	LOC101155470	Uncharacterized protein. (210 aa)
	mydgf	Myeloid-derived growth factor. (205 aa)
	JMJD8	Jumonji domain containing 8. (283 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000031846	H2LZ22_ORYLA	ENSORLP00000031846	ENSORLP00000011393	Uncharacterized protein.	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family.	0.873
ENSORLP00000031846	LOC101157704	ENSORLP00000031846	ENSORLP00000016295	Uncharacterized protein.	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family.	0.875
Fgf1	fgf18	ENSORLP00000001852	ENSORLP00000038417	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.595
Fgf1	gab1	ENSORLP00000001852	ENSORLP00000041732	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	GRB2-associated binding protein 1.	0.577
Fgf1	mydgf	ENSORLP00000001852	ENSORLP00000043836	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Myeloid-derived growth factor.	0.502
H2LZ22_ORYLA	ENSORLP00000031846	ENSORLP00000011393	ENSORLP00000031846	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.873
H2LZ22_ORYLA	LOC101157704	ENSORLP00000011393	ENSORLP00000016295	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family.	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family.	0.907
LOC100301586	LOC101169209	ENSORLP00000033631	ENSORLP00000036862	CD40 molecule, TNF receptor superfamily member 5.	Uncharacterized protein.	0.581
LOC100301586	il10	ENSORLP00000033631	ENSORLP00000019691	CD40 molecule, TNF receptor superfamily member 5.	Interleukin 10.	0.640
LOC101155470	am3	ENSORLP00000042859	ENSORLP00000044870	Uncharacterized protein.	Adrenomedullin 3.	0.712
LOC101155633	LOC101160921	ENSORLP00000012477	ENSORLP00000036285	Uncharacterized protein.	Si:ch211-39a7.1.	0.550
LOC101155633	LOC101162456	ENSORLP00000012477	ENSORLP00000003993	Uncharacterized protein.	Si:ch73-380n15.2.	0.553
LOC101155633	LOC101166204	ENSORLP00000012477	ENSORLP00000036519	Uncharacterized protein.	Uncharacterized protein.	0.551
LOC101155633	LOC101167346	ENSORLP00000012477	ENSORLP00000017907	Uncharacterized protein.	Uncharacterized protein.	0.551
LOC101155633	LOC101168927	ENSORLP00000012477	ENSORLP00000026327	Uncharacterized protein.	Uncharacterized protein.	0.550
LOC101157091	fgf18	ENSORLP00000040455	ENSORLP00000038417	PH domain-containing protein.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.543
LOC101157091	gab1	ENSORLP00000040455	ENSORLP00000041732	PH domain-containing protein.	GRB2-associated binding protein 1.	0.900
LOC101157704	ENSORLP00000031846	ENSORLP00000016295	ENSORLP00000031846	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.875
LOC101157704	H2LZ22_ORYLA	ENSORLP00000016295	ENSORLP00000011393	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family.	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family.	0.907
LOC101160921	LOC101155633	ENSORLP00000036285	ENSORLP00000012477	Si:ch211-39a7.1.	Uncharacterized protein.	0.550