(43 nodes) Neuron fate commitment network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	isl1	Uncharacterized protein. (349 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
	LOC101164996	Fork-head domain-containing protein. (340 aa)
	dlx3	Distal-less homeobox 3b. (278 aa)
	axin1	Axin 1. (854 aa)
	atoh1	Atonal bHLH transcription factor 1a. (351 aa)
	SMAD4	Mothers against decapentaplegic homolog. (510 aa)
	fkbp8	Peptidylprolyl isomerase. (401 aa)
	gsx1	Developmental transcription factor. (243 aa)
	lhx3	Uncharacterized protein. (401 aa)
	foxn4	Forkhead box N4. (516 aa)
	ISL2	ISL LIM homeobox 2a. (358 aa)
	hoxc8	Homeobox C10a. (376 aa)
	zc4h2	Zinc finger, C4H2 domain containing. (224 aa)
	LOC101164249	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (406 aa)
	lhx9	LIM homeobox 9. (399 aa)
	LOC101156111	T-box transcription factor 2a. (561 aa)
	olig2	Oligodendrocyte lineage transcription factor 2. (268 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
	mnx1	Motor neuron and pancreas homeobox 1. (317 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	foxg1	Fork-head domain-containing protein. (461 aa)
	ISL2-2	Uncharacterized protein. (364 aa)
	TBX2	T-box transcription factor 2. (682 aa)
	id2	Inhibitor of DNA binding 2a. (137 aa)
	lhx2	LIM homeobox 2b. (417 aa)
	lhx4	LIM homeobox 4. (389 aa)
	gbx1	Gastrulation brain homeobox 1. (322 aa)
	LOC101163780	Oligodendrocyte transcription factor 4. (258 aa)
	H2MVL3_ORYLA	Homeobox domain-containing protein. (130 aa)
	gsx2	GS homeobox 2. (238 aa)
	LOC101175327	Atonal bHLH transcription factor 1b. (229 aa)
	LOC100301613	Forkhead box G2. (387 aa)
	LOC101173916	Mothers against decapentaplegic homolog. (538 aa)
	LOC105354225	Peptidylprolyl isomerase. (474 aa)
	thrb	Thyroid hormone receptor beta. (378 aa)
	mib1	Mindbomb E3 ubiquitin protein ligase 1. (1081 aa)
	LOC101155206	Uncharacterized protein. (350 aa)
	LOC101163504	Mothers against decapentaplegic homolog. (528 aa)
	LOC101155494	Uncharacterized protein. (883 aa)
	gdf5	Growth differentiation factor 5. (567 aa)
	LOC101171064	Growth differentiation factor 6a. (437 aa)
	ENSORLP00000041481	Oligodendrocyte transcription factor 1. (162 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000041481	atoh1	ENSORLP00000041481	ENSORLP00000006139	Oligodendrocyte transcription factor 1.	Atonal bHLH transcription factor 1a.	0.587
ISL2	lhx3	ENSORLP00000009843	ENSORLP00000008410	ISL LIM homeobox 2a.	Uncharacterized protein.	0.773
ISL2	lhx4	ENSORLP00000009843	ENSORLP00000021711	ISL LIM homeobox 2a.	LIM homeobox 4.	0.773
ISL2-2	lhx3	ENSORLP00000015476	ENSORLP00000008410	Uncharacterized protein.	Uncharacterized protein.	0.782
ISL2-2	lhx4	ENSORLP00000015476	ENSORLP00000021711	Uncharacterized protein.	LIM homeobox 4.	0.773
LOC100301613	LOC101163504	ENSORLP00000027285	ENSORLP00000045202	Forkhead box G2.	Mothers against decapentaplegic homolog.	0.459
LOC100301613	LOC101173916	ENSORLP00000027285	ENSORLP00000029700	Forkhead box G2.	Mothers against decapentaplegic homolog.	0.459
LOC100301613	SMAD4	ENSORLP00000027285	ENSORLP00000006328	Forkhead box G2.	Mothers against decapentaplegic homolog.	0.459
LOC101155494	axin1	ENSORLP00000038069	ENSORLP00000006039	Uncharacterized protein.	Axin 1.	0.552
LOC101163504	LOC100301613	ENSORLP00000045202	ENSORLP00000027285	Mothers against decapentaplegic homolog.	Forkhead box G2.	0.459
LOC101163504	LOC101164996	ENSORLP00000045202	ENSORLP00000002601	Mothers against decapentaplegic homolog.	Fork-head domain-containing protein.	0.459
LOC101163504	LOC101173916	ENSORLP00000045202	ENSORLP00000029700	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.902
LOC101163504	SMAD4	ENSORLP00000045202	ENSORLP00000006328	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.900
LOC101163504	foxg1	ENSORLP00000045202	ENSORLP00000013442	Mothers against decapentaplegic homolog.	Fork-head domain-containing protein.	0.459
LOC101164996	LOC101163504	ENSORLP00000002601	ENSORLP00000045202	Fork-head domain-containing protein.	Mothers against decapentaplegic homolog.	0.459
LOC101164996	LOC101173916	ENSORLP00000002601	ENSORLP00000029700	Fork-head domain-containing protein.	Mothers against decapentaplegic homolog.	0.459
LOC101164996	SMAD4	ENSORLP00000002601	ENSORLP00000006328	Fork-head domain-containing protein.	Mothers against decapentaplegic homolog.	0.459
LOC101164996	fgf3	ENSORLP00000002601	ENSORLP00000000370	Fork-head domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.534
LOC101173916	LOC100301613	ENSORLP00000029700	ENSORLP00000027285	Mothers against decapentaplegic homolog.	Forkhead box G2.	0.459
LOC101173916	LOC101163504	ENSORLP00000029700	ENSORLP00000045202	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.902