STRINGSTRING
rspo2 rspo2 LOC101157631 LOC101157631 Fgf1 Fgf1 sars1 sars1 LOC101174677 LOC101174677 ppp3r1 ppp3r1 nfatc4 nfatc4 LOC101171361 LOC101171361 ILK ILK LOC101171145 LOC101171145 LOC101172012 LOC101172012 SMAD4 SMAD4 LOC101161650 LOC101161650 lef1 lef1 hhip hhip ednra ednra gdnf gdnf msc msc ar-alpha ar-alpha sfrp2 sfrp2 edn1 edn1 LOC100049233 LOC100049233 nrarp nrarp LOC101168287 LOC101168287 ENSORLP00000045928 ENSORLP00000045928 LOC101163504 LOC101163504 dag1 dag1 LOC101171428 LOC101171428 greb1 greb1 wt1 wt1 srf srf mks1 mks1 wnt6 wnt6 pkd1 pkd1 lrp5 lrp5 LOC101168674 LOC101168674 LOC101167695 LOC101167695 ctsh ctsh LOC101173916 LOC101173916 gbx2 gbx2 tcf21 tcf21 LOC105358811 LOC105358811 timeless timeless LOC101174943 LOC101174943 LOC101167461 LOC101167461 LOC101165732 LOC101165732 ctsz ctsz wt1-2 wt1-2 lrp6 lrp6 LOC101174785 LOC101174785 TGFBR2 TGFBR2 med1 med1 LOC101172686 LOC101172686
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rspo2R-spondin-2. (245 aa)
LOC101157631Transforming growth factor beta; Belongs to the TGF-beta family. (444 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (159 aa)
sars1Seryl-tRNA synthetase. (516 aa)
LOC101174677Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (464 aa)
ppp3r1Uncharacterized protein. (170 aa)
nfatc4Nuclear factor of activated T cells 4. (806 aa)
LOC101171361Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (305 aa)
ILKIntegrin linked kinase. (452 aa)
LOC101171145Sprouty RTK signaling antagonist 2. (342 aa)
LOC101172012Uncharacterized protein. (452 aa)
SMAD4Mothers against decapentaplegic homolog. (510 aa)
LOC101161650Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (157 aa)
lef1Lymphoid enhancer-binding factor 1. (379 aa)
hhipHedgehog interacting protein. (703 aa)
ednraEndothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (439 aa)
gdnfGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (265 aa)
mscMusculin (activated B-cell factor-1). (166 aa)
ar-alphaUncharacterized protein. (687 aa)
sfrp2Secreted frizzled-related protein 2. (290 aa)
edn1Endothelin 1. (220 aa)
LOC100049233Androgen receptor beta subtype. (744 aa)
nrarpNOTCH regulated ankyrin repeat protein a. (112 aa)
LOC101168287Colony stimulating factor 1b (macrophage). (301 aa)
ENSORLP00000045928Catenin, beta interacting protein 1. (83 aa)
LOC101163504Mothers against decapentaplegic homolog. (528 aa)
dag1Dystroglycan 1. (868 aa)
LOC101171428FZ domain-containing protein. (337 aa)
greb1Growth regulating estrogen receptor binding 1. (1927 aa)
wt1Uncharacterized protein. (435 aa)
srfSerum response factor b. (611 aa)
mks1MKS transition zone complex subunit 1. (563 aa)
wnt6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
pkd1Uncharacterized protein. (4114 aa)
lrp5Low density lipoprotein receptor-related protein 5. (1634 aa)
LOC101168674Uncharacterized protein. (179 aa)
LOC101167695Transmembrane protein 59-like. (338 aa)
ctshCathepsin H; Belongs to the peptidase C1 family. (324 aa)
LOC101173916Mothers against decapentaplegic homolog. (538 aa)
gbx2Gastrulation brain homeobox 2. (350 aa)
tcf21Transcription factor 21. (171 aa)
LOC105358811MADS-box domain-containing protein. (552 aa)
timelessTimeless circadian clock. (1244 aa)
LOC101174943Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (2042 aa)
LOC101167461NK3 homeobox 1. (188 aa)
LOC101165732Peptidase S72 domain-containing protein. (901 aa)
ctszCathepsin Z; Belongs to the peptidase C1 family. (355 aa)
wt1-2Uncharacterized protein. (418 aa)
lrp6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1623 aa)
LOC101174785TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (587 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1782 aa)
LOC101172686Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (445 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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