(18 nodes) Neuromast development network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	slc44a4	Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (714 aa)
	abhd12	Abhydrolase domain containing 12. (375 aa)
	VANGL2	Vang-like protein. (525 aa)
	rspo3	R-spondin-3. (328 aa)
	LOC101160069	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (448 aa)
	lrrc1	Leucine rich repeat containing 1. (497 aa)
	LOC101165493	Transmembrane O-methyltransferase. (259 aa)
	H2MA54_ORYLA	Uncharacterized protein. (489 aa)
	LOC101158452	Transmembrane channel-like protein. (917 aa)
	znrf3	Zinc and ring finger 3. (871 aa)
	tmem132e	Transmembrane protein 132E. (1081 aa)
	llgl2	LLGL scribble cell polarity complex component 2. (1024 aa)
	LOC101162818	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
	neurog1	Neurogenin 1. (195 aa)
	neurod1	Neurogenic differentiation factor. (350 aa)
	LOC101160003	Mothers against decapentaplegic homolog. (464 aa)
	wnt5b	Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). (436 aa)
	LOC101158573	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2MA54_ORYLA	VANGL2	ENSORLP00000015402	ENSORLP00000003569	Uncharacterized protein.	Vang-like protein.	0.596
LOC101160069	VANGL2	ENSORLP00000011063	ENSORLP00000003569	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Vang-like protein.	0.600
LOC101160069	wnt5b	ENSORLP00000011063	ENSORLP00000032981	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).	0.901
VANGL2	H2MA54_ORYLA	ENSORLP00000003569	ENSORLP00000015402	Vang-like protein.	Uncharacterized protein.	0.596
VANGL2	LOC101160069	ENSORLP00000003569	ENSORLP00000011063	Vang-like protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.600
VANGL2	lrrc1	ENSORLP00000003569	ENSORLP00000012353	Vang-like protein.	Leucine rich repeat containing 1.	0.596
VANGL2	wnt5b	ENSORLP00000003569	ENSORLP00000032981	Vang-like protein.	Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).	0.482
lrrc1	VANGL2	ENSORLP00000012353	ENSORLP00000003569	Leucine rich repeat containing 1.	Vang-like protein.	0.596
rspo3	znrf3	ENSORLP00000007233	ENSORLP00000044251	R-spondin-3.	Zinc and ring finger 3.	0.985
wnt5b	LOC101160069	ENSORLP00000032981	ENSORLP00000011063	Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901
wnt5b	VANGL2	ENSORLP00000032981	ENSORLP00000003569	Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).	Vang-like protein.	0.482
znrf3	rspo3	ENSORLP00000044251	ENSORLP00000007233	Zinc and ring finger 3.	R-spondin-3.	0.985