(82 nodes) Regulation of lymphocyte proliferation network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101161479	Interleukin 12 receptor, beta 2a. (783 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (252 aa)
	LOC101168710	TNFR-Cys domain-containing protein. (236 aa)
	card11	Caspase recruitment domain family, member 11. (1146 aa)
	H2ME57_ORYLA	V-set immunoregulatory receptor. (288 aa)
	LOC101171114	Arginase. (322 aa)
	LOC101168676	CD38 molecule. (264 aa)
	dhps	Deoxyhypusine synthase. (360 aa)
	LOC101166554	ATPase family AAA domain containing 5a. (1758 aa)
	1-sf	ZP domain-containing protein. (420 aa)
	H2M2N2_ORYLA	Uncharacterized protein. (150 aa)
	arg2	Arginase. (349 aa)
	nck1	Cytoplasmic protein. (392 aa)
	LOC101161201	Galectin. (373 aa)
	sos2	Son of sevenless homolog 2 (Drosophila). (1323 aa)
	LOC101168078	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily. (481 aa)
	tmem131l	Transmembrane 131 like. (1513 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (590 aa)
	AIF1	Allograft inflammatory factor 1. (154 aa)
	LOC101165568	Uncharacterized protein. (645 aa)
	H2LPR9_ORYLA	HERV-H LTR-associating 2a, tandem duplicate 2. (462 aa)
	glmn	Glomulin, FKBP associated protein a. (588 aa)
	LOC101154797	Solute carrier family 7 member 1a. (647 aa)
	gpnmb	Glycoprotein (transmembrane) nmb. (612 aa)
	LOC101167049	CD40 ligand; Belongs to the tumor necrosis factor family. (239 aa)
	LOC101157631	Transforming growth factor beta; Belongs to the TGF-beta family. (444 aa)
	sash3	SAM and SH3 domain containing 3. (391 aa)
	LOC101163430	Interferon regulatory factor. (293 aa)
	sh3rf1	SH3 domain containing ring finger 1. (880 aa)
	ENSORLP00000044779	Uncharacterized protein. (511 aa)
	mad1l1	Mitotic arrest deficient 1 like 1. (722 aa)
	fadd	Uncharacterized protein. (192 aa)
	LOC101167949	E3 ubiquitin-protein ligase. (879 aa)
	cd276	CD276 molecule. (302 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
	ENSORLP00000040878	Ig-like domain-containing protein. (126 aa)
	tyrobp	Uncharacterized protein. (142 aa)
	ENSORLP00000039947	Ig-like domain-containing protein. (361 aa)
	ENSORLP00000039599	Uncharacterized protein. (486 aa)
	nck2	Cytoplasmic protein. (398 aa)
	igf2	Insulin-like growth factor 2b. (212 aa)
	LOC101168658-2	Uncharacterized protein. (257 aa)
	lrrc32	Leucine rich repeat containing 32. (678 aa)
	LOC101172133	ATPase family AAA domain containing 5b. (959 aa)
	ENSORLP00000037698	Uncharacterized protein. (305 aa)
	LOC101169209	Uncharacterized protein. (283 aa)
	syk	Tyrosine-protein kinase. (624 aa)
	LOC101174746	E3 ubiquitin-protein ligase. (877 aa)
	pawr	PRKC, apoptosis, WT1, regulator. (323 aa)
	rassf5	Ras association domain family member 5. (505 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1343 aa)
	LOC101174943	Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (2042 aa)
	ENSORLP00000034778	Uncharacterized protein. (380 aa)
	SLC7A1	Solute carrier family 7 member 1. (667 aa)
	LOC100301586	CD40 molecule, TNF receptor superfamily member 5. (305 aa)
	ENSORLP00000033332	Uncharacterized protein. (377 aa)
	LOC111949120	Cytokine receptor family member B16. (310 aa)
	mpl	MPL proto-oncogene, thrombopoietin receptor. (631 aa)
	LOC101160820	SCY domain-containing protein. (131 aa)
	marchf7	Membrane-associated ring finger (C3HC4) 7. (807 aa)
	LOC101168285	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (415 aa)
	LOC101168658	Uncharacterized protein. (275 aa)
	LOC101168038	Protein kinase domain-containing protein. (509 aa)
	LOC101170171	Zeta chain of T cell receptor associated protein kinase 70. (668 aa)
	LOC101161312	Zgc:153759. (282 aa)
	LOC101159552	Galectin. (314 aa)
	ENSORLP00000027619	TAN domain-containing protein. (321 aa)
	ENSORLP00000026992	Ig-like domain-containing protein. (157 aa)
	sos1	Son of sevenless homolog 1 (Drosophila). (1297 aa)
	LOC101168159	Uncharacterized protein. (299 aa)
	gpam	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (823 aa)
	Atm	Uncharacterized protein. (147 aa)
	il6st	Uncharacterized protein. (868 aa)
	H2MWT7_ORYLA	Uncharacterized protein. (246 aa)
	LOC101173752	IGv domain-containing protein. (224 aa)
	tnfsf13b	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (252 aa)
	LOC101171005	Nuclear factor of activated T cells 2a. (893 aa)
	LOC101158138	Ring finger and CCCH-type domains 1b. (1116 aa)
	il10	Interleukin 10. (181 aa)
	tnfrsf21	Tumor necrosis factor receptor superfamily, member 21. (651 aa)
	inpp5d	Inositol polyphosphate-5-phosphatase D. (1092 aa)
	LOC101155601	CCAAT enhancer binding protein beta. (286 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIF1	LOC101169209	ENSORLP00000008655	ENSORLP00000036862	Allograft inflammatory factor 1.	Uncharacterized protein.	0.589
AIF1	il10	ENSORLP00000008655	ENSORLP00000019691	Allograft inflammatory factor 1.	Interleukin 10.	0.549
AIF1	ptprc	ENSORLP00000008655	ENSORLP00000035490	Allograft inflammatory factor 1.	Protein tyrosine phosphatase receptor type C.	0.473
AIF1	tyrobp	ENSORLP00000008655	ENSORLP00000040436	Allograft inflammatory factor 1.	Uncharacterized protein.	0.879
Atm	ENSORLP00000027619	ENSORLP00000026266	ENSORLP00000027619	Uncharacterized protein.	TAN domain-containing protein.	0.929
Atm	LOC101166554	ENSORLP00000026266	ENSORLP00000012809	Uncharacterized protein.	ATPase family AAA domain containing 5a.	0.556
Atm	LOC101172133	ENSORLP00000026266	ENSORLP00000038541	Uncharacterized protein.	ATPase family AAA domain containing 5b.	0.556
ENSORLP00000027619	Atm	ENSORLP00000027619	ENSORLP00000026266	TAN domain-containing protein.	Uncharacterized protein.	0.929
ENSORLP00000027619	LOC101166554	ENSORLP00000027619	ENSORLP00000012809	TAN domain-containing protein.	ATPase family AAA domain containing 5a.	0.556
ENSORLP00000027619	LOC101172133	ENSORLP00000027619	ENSORLP00000038541	TAN domain-containing protein.	ATPase family AAA domain containing 5b.	0.556
ENSORLP00000037698	LOC101157631	ENSORLP00000037698	ENSORLP00000001563	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.407
ENSORLP00000037698	LOC101168710	ENSORLP00000037698	ENSORLP00000017445	Uncharacterized protein.	TNFR-Cys domain-containing protein.	0.457
ENSORLP00000037698	il10	ENSORLP00000037698	ENSORLP00000019691	Uncharacterized protein.	Interleukin 10.	0.474
H2M2N2_ORYLA	LOC101167049	ENSORLP00000012678	ENSORLP00000002171	Uncharacterized protein.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.429
H2M2N2_ORYLA	LOC101169209	ENSORLP00000012678	ENSORLP00000036862	Uncharacterized protein.	Uncharacterized protein.	0.728
H2M2N2_ORYLA	il10	ENSORLP00000012678	ENSORLP00000019691	Uncharacterized protein.	Interleukin 10.	0.726
LOC100301586	LOC101167049	ENSORLP00000033631	ENSORLP00000002171	CD40 molecule, TNF receptor superfamily member 5.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.980
LOC100301586	LOC101168710	ENSORLP00000033631	ENSORLP00000017445	CD40 molecule, TNF receptor superfamily member 5.	TNFR-Cys domain-containing protein.	0.564
LOC100301586	LOC101169209	ENSORLP00000033631	ENSORLP00000036862	CD40 molecule, TNF receptor superfamily member 5.	Uncharacterized protein.	0.581
LOC100301586	LOC101173752	ENSORLP00000033631	ENSORLP00000022838	CD40 molecule, TNF receptor superfamily member 5.	IGv domain-containing protein.	0.670