(68 nodes) Epithelial cell proliferation network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101168687	Zgc:153993. (293 aa)
	WDR77	WD repeat domain 77. (367 aa)
	LOC101157631	Transforming growth factor beta; Belongs to the TGF-beta family. (444 aa)
	LOC101166137	EGF-like domain-containing protein. (154 aa)
	LOC101157923	Insulin-like growth factor binding protein 5a. (253 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
	IGFBP4	Insulin like growth factor binding protein 4. (261 aa)
	NCSTN	Nicastrin. (677 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1056 aa)
	ift74	Intraflagellar transport 74. (581 aa)
	sdr16c5	Short chain dehydrogenase/reductase family 16C, member 5a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (306 aa)
	LOC101164972	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	LOC101173499	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (491 aa)
	nkx2-5	Homeobox domain-containing protein. (319 aa)
	H2LU26_ORYLA	Lysyl oxidase-like 4. (342 aa)
	wnt2bb	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	ar-alpha	Uncharacterized protein. (687 aa)
	NKX2-8	NK2 homeobox 8. (236 aa)
	H2LYC2_ORYLA	Fibrinogen-like 1. (323 aa)
	sav1	Salvador family WW domain containing protein 1. (391 aa)
	LOC100049233	Androgen receptor beta subtype. (744 aa)
	LOC101154988	ELL associated factor 2. (264 aa)
	nrarp	NOTCH regulated ankyrin repeat protein a. (112 aa)
	LOC101172593	Tumor necrosis factor a (TNF superfamily, member 2). (279 aa)
	flcn	Folliculin. (558 aa)
	LOC101168600	Si:cabz01100188.1. (905 aa)
	ift52	Intraflagellar transport 52 homolog (Chlamydomonas). (433 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (387 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (828 aa)
	st8sia1	Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (332 aa)
	id2	Inhibitor of DNA binding 2a. (137 aa)
	LOC101155601	CCAAT enhancer binding protein beta. (286 aa)
	H2MJT0_ORYLA	Uncharacterized protein. (589 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (198 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
	amotl2	Angiomotin like 2a. (697 aa)
	bmper	BMP binding endothelial regulator. (683 aa)
	LOC101169721	Apolipoprotein A-Ib. (323 aa)
	LOC101159857	Angiomotin like 2b. (688 aa)
	IGFBP3	Insulin like growth factor binding protein 3. (292 aa)
	wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	LOC101169757	Fibrinogen C-terminal domain-containing protein. (332 aa)
	LOC101162030	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
	phox2b	Paired like homeobox 2Bb. (285 aa)
	Nf1	Uncharacterized protein. (506 aa)
	ift80	Intraflagellar transport 80 homolog (Chlamydomonas). (786 aa)
	ENSORLP00000027381	Lysyl oxidase-like 4. (265 aa)
	xbp1	X-box binding protein 1. (259 aa)
	ENSORLP00000028183	Uncharacterized protein. (250 aa)
	scarb1	Scavenger receptor class B, member 1; Belongs to the CD36 family. (532 aa)
	ehf	Ets homologous factor. (274 aa)
	ppard	Uncharacterized protein. (517 aa)
	bad	BCL2 associated agonist of cell death b. (164 aa)
	prkx	Protein kinase X-linked; Belongs to the protein kinase superfamily. (358 aa)
	prok2	Prokineticin 2. (131 aa)
	LOC101167461	NK3 homeobox 1. (188 aa)
	LOC101172423	Keratinocyte differentiation factor 1b. (349 aa)
	rb1	Retinoblastoma 1. (916 aa)
	LOC101166855	Transforming growth factor, alpha. (254 aa)
	CCN3	Cellular communication network factor 3. (366 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (262 aa)
	LOC101173508	Marker of proliferation Ki-67. (1982 aa)
	LOC101155067	Insulin-like growth factor binding protein 5a. (266 aa)
	LOC105357487	Activin_recp domain-containing protein. (762 aa)
	lmo2	LIM domain only 2 (rhombotin-like 1). (160 aa)
	prok1	Prokineticin 1. (106 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1782 aa)
	kdf1	Keratinocyte differentiation factor 1a. (391 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000027381	H2LU26_ORYLA	ENSORLP00000027381	ENSORLP00000009599	Lysyl oxidase-like 4.	Lysyl oxidase-like 4.	0.893
H2LU26_ORYLA	ENSORLP00000027381	ENSORLP00000009599	ENSORLP00000027381	Lysyl oxidase-like 4.	Lysyl oxidase-like 4.	0.893
H2MJT0_ORYLA	Nf1	ENSORLP00000018929	ENSORLP00000026133	Uncharacterized protein.	Uncharacterized protein.	0.943
H2MJT0_ORYLA	WDR77	ENSORLP00000018929	ENSORLP00000000652	Uncharacterized protein.	WD repeat domain 77.	0.443
H2MJT0_ORYLA	ift80	ENSORLP00000018929	ENSORLP00000026839	Uncharacterized protein.	Intraflagellar transport 80 homolog (Chlamydomonas).	0.443
H2MJT0_ORYLA	stk11	ENSORLP00000018929	ENSORLP00000019300	Uncharacterized protein.	Serine/threonine kinase 11; Belongs to the protein kinase superfamily.	0.411
IGFBP3	LOC101155067	ENSORLP00000021459	ENSORLP00000041462	Insulin like growth factor binding protein 3.	Insulin-like growth factor binding protein 5a.	0.459
IGFBP3	LOC101157923	ENSORLP00000021459	ENSORLP00000002784	Insulin like growth factor binding protein 3.	Insulin-like growth factor binding protein 5a.	0.419
LOC100049233	LOC101167461	ENSORLP00000011941	ENSORLP00000035844	Androgen receptor beta subtype.	NK3 homeobox 1.	0.494
LOC100049233	ar-alpha	ENSORLP00000011941	ENSORLP00000010323	Androgen receptor beta subtype.	Uncharacterized protein.	0.908
LOC100049233	med1	ENSORLP00000011941	ENSORLP00000043584	Androgen receptor beta subtype.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.576
LOC101155067	IGFBP3	ENSORLP00000041462	ENSORLP00000021459	Insulin-like growth factor binding protein 5a.	Insulin like growth factor binding protein 3.	0.459
LOC101155601	LOC101172593	ENSORLP00000018839	ENSORLP00000013121	CCAAT enhancer binding protein beta.	Tumor necrosis factor a (TNF superfamily, member 2).	0.485
LOC101155601	bmpr2	ENSORLP00000018839	ENSORLP00000003793	CCAAT enhancer binding protein beta.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.414
LOC101157631	LOC101172593	ENSORLP00000001563	ENSORLP00000013121	Transforming growth factor beta; Belongs to the TGF-beta family.	Tumor necrosis factor a (TNF superfamily, member 2).	0.576
LOC101157631	LOC105357487	ENSORLP00000001563	ENSORLP00000042845	Transforming growth factor beta; Belongs to the TGF-beta family.	Activin_recp domain-containing protein.	0.449
LOC101157631	bmpr2	ENSORLP00000001563	ENSORLP00000003793	Transforming growth factor beta; Belongs to the TGF-beta family.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.547
LOC101157631	fgf7	ENSORLP00000001563	ENSORLP00000002929	Transforming growth factor beta; Belongs to the TGF-beta family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.567
LOC101157923	IGFBP3	ENSORLP00000002784	ENSORLP00000021459	Insulin-like growth factor binding protein 5a.	Insulin like growth factor binding protein 3.	0.419
LOC101159857	amotl2	ENSORLP00000020369	ENSORLP00000019350	Angiomotin like 2b.	Angiomotin like 2a.	0.903