(30 nodes) Negative regulation of protein secretion network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (466 aa)
	CCN3	Cellular communication network factor 3. (366 aa)
	LOC101166888	3-hydroxy-3-methylglutaryl coenzyme A reductase. (853 aa)
	LOC101173256	Uncharacterized protein. (328 aa)
	RHBDF2	Rhomboid 5 homolog 2. (815 aa)
	LOC101167634	Coagulation factor II thrombin receptor. (440 aa)
	LOC101166616	Midnolin. (536 aa)
	LOC101166279	Rhomboid 5 homolog 1b (Drosophila). (901 aa)
	rhbdf1	Rhomboid 5 homolog 1a (Drosophila). (893 aa)
	KLF7	Kruppel like factor 7. (299 aa)
	LOC101173120	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (390 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (311 aa)
	LOC101173126	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family. (382 aa)
	chga	Uncharacterized protein. (315 aa)
	LOC100125499	3-hydroxy-3-methylglutaryl coenzyme A reductase. (865 aa)
	kcnj8	Potassium inwardly-rectifying channel, subfamily J, member 8. (417 aa)
	LOC101161673	Apolipoprotein Eb. (265 aa)
	LOC111948766	Uncharacterized protein. (294 aa)
	pim3	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (329 aa)
	LOC101156209	Kruppel-like factor 7b. (298 aa)
	LOC111946296	Ig-like domain-containing protein. (291 aa)
	LOC101168024	Ig-like domain-containing protein. (271 aa)
	psmd9	Proteasome 26S subunit, non-ATPase 9. (212 aa)
	ndufaf2	NADH:ubiquinone oxidoreductase complex assembly factor 2. (161 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (320 aa)
	LOC101164385	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (383 aa)
	sergef	Secretion regulating guanine nucleotide exchange factor. (438 aa)
	drd3	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (456 aa)
	Kcnj11	Potassium inwardly-rectifying channel, subfamily J, member 11. (269 aa)
	LOC101166399	Apolipoprotein Ea. (262 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Kcnj11	sergef	ENSORLP00000042977	ENSORLP00000042523	Potassium inwardly-rectifying channel, subfamily J, member 11.	Secretion regulating guanine nucleotide exchange factor.	0.824
LOC100125499	LOC101161673	ENSORLP00000021654	ENSORLP00000017533	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Apolipoprotein Eb.	0.457
LOC100125499	LOC101166888	ENSORLP00000021654	ENSORLP00000039405	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.902
LOC101161673	LOC100125499	ENSORLP00000017533	ENSORLP00000021654	Apolipoprotein Eb.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.457
LOC101161673	LOC101166399	ENSORLP00000017533	ENSORLP00000045105	Apolipoprotein Eb.	Apolipoprotein Ea.	0.566
LOC101164385	drd3	ENSORLP00000000107	ENSORLP00000042570	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.577
LOC101166399	LOC101161673	ENSORLP00000045105	ENSORLP00000017533	Apolipoprotein Ea.	Apolipoprotein Eb.	0.566
LOC101166888	LOC100125499	ENSORLP00000039405	ENSORLP00000021654	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.902
LOC101173120	drd3	ENSORLP00000024963	ENSORLP00000042570	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.577
LOC101173126	drd3	ENSORLP00000024111	ENSORLP00000042570	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.577
drd3	LOC101164385	ENSORLP00000042570	ENSORLP00000000107	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family.	0.577
drd3	LOC101173120	ENSORLP00000042570	ENSORLP00000024963	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.577
drd3	LOC101173126	ENSORLP00000042570	ENSORLP00000024111	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family.	0.577
sergef	Kcnj11	ENSORLP00000042523	ENSORLP00000042977	Secretion regulating guanine nucleotide exchange factor.	Potassium inwardly-rectifying channel, subfamily J, member 11.	0.824