(15 nodes) Low-density lipoprotein particle receptor binding network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pcsk9	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (642 aa)
	cltcl1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1658 aa)
	dab2	DAB adaptor protein 2. (761 aa)
	ankra2	Ankyrin repeat, family A (RFXANK-like), 2. (311 aa)
	hsp90b1	Heat shock protein 90, beta (grp94), member 1. (796 aa)
	LOC101172518	Dickkopf WNT signaling pathway inhibitor 1a. (244 aa)
	H2MBB3_ORYLA	Vitellogenin domain-containing protein. (793 aa)
	LOC101158990	Apolipoprotein Bb, tandem duplicate 2. (2459 aa)
	LOC101157554	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1677 aa)
	LOC101161673	Apolipoprotein Eb. (265 aa)
	ap2a1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (983 aa)
	ldlrap1	Low density lipoprotein receptor adaptor protein 1b. (320 aa)
	lrpap1	Low density lipoprotein receptor-related protein associated protein 1. (476 aa)
	cltc	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1695 aa)
	LOC101156458	Apolipoprotein Ba. (4366 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2MBB3_ORYLA	LOC101156458	ENSORLP00000015834	ENSORLP00000041747	Vitellogenin domain-containing protein.	Apolipoprotein Ba.	0.562
H2MBB3_ORYLA	LOC101158990	ENSORLP00000015834	ENSORLP00000015852	Vitellogenin domain-containing protein.	Apolipoprotein Bb, tandem duplicate 2.	0.555
H2MBB3_ORYLA	LOC101161673	ENSORLP00000015834	ENSORLP00000017533	Vitellogenin domain-containing protein.	Apolipoprotein Eb.	0.896
H2MBB3_ORYLA	ap2a1	ENSORLP00000015834	ENSORLP00000021377	Vitellogenin domain-containing protein.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.478
H2MBB3_ORYLA	dab2	ENSORLP00000015834	ENSORLP00000003668	Vitellogenin domain-containing protein.	DAB adaptor protein 2.	0.516
H2MBB3_ORYLA	hsp90b1	ENSORLP00000015834	ENSORLP00000005467	Vitellogenin domain-containing protein.	Heat shock protein 90, beta (grp94), member 1.	0.530
H2MBB3_ORYLA	ldlrap1	ENSORLP00000015834	ENSORLP00000021954	Vitellogenin domain-containing protein.	Low density lipoprotein receptor adaptor protein 1b.	0.677
H2MBB3_ORYLA	pcsk9	ENSORLP00000015834	ENSORLP00000002020	Vitellogenin domain-containing protein.	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family.	0.416
LOC101156458	H2MBB3_ORYLA	ENSORLP00000041747	ENSORLP00000015834	Apolipoprotein Ba.	Vitellogenin domain-containing protein.	0.562
LOC101156458	LOC101158990	ENSORLP00000041747	ENSORLP00000015852	Apolipoprotein Ba.	Apolipoprotein Bb, tandem duplicate 2.	0.565
LOC101156458	LOC101161673	ENSORLP00000041747	ENSORLP00000017533	Apolipoprotein Ba.	Apolipoprotein Eb.	0.941
LOC101156458	ap2a1	ENSORLP00000041747	ENSORLP00000021377	Apolipoprotein Ba.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.478
LOC101156458	dab2	ENSORLP00000041747	ENSORLP00000003668	Apolipoprotein Ba.	DAB adaptor protein 2.	0.516
LOC101156458	hsp90b1	ENSORLP00000041747	ENSORLP00000005467	Apolipoprotein Ba.	Heat shock protein 90, beta (grp94), member 1.	0.530
LOC101156458	ldlrap1	ENSORLP00000041747	ENSORLP00000021954	Apolipoprotein Ba.	Low density lipoprotein receptor adaptor protein 1b.	0.677
LOC101156458	pcsk9	ENSORLP00000041747	ENSORLP00000002020	Apolipoprotein Ba.	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family.	0.416
LOC101157554	ap2a1	ENSORLP00000016578	ENSORLP00000021377	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.971
LOC101157554	cltc	ENSORLP00000016578	ENSORLP00000033788	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.900
LOC101157554	cltcl1	ENSORLP00000016578	ENSORLP00000002883	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.900
LOC101157554	dab2	ENSORLP00000016578	ENSORLP00000003668	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	DAB adaptor protein 2.	0.653