(68 nodes) Positive regulation of NF-kappaB transcription factor activity network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tnfrsf11a	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator. (639 aa)
	ENSORLP00000044435	Uncharacterized protein. (555 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
	LOC101167049	CD40 ligand; Belongs to the tumor necrosis factor family. (239 aa)
	card14	Caspase recruitment domain family, member 14. (972 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (801 aa)
	LOC101160197	E1A binding protein p300 a. (2781 aa)
	LOC101155367	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (596 aa)
	MTDH	Uncharacterized protein. (537 aa)
	nod1	Nucleotide-binding oligomerization domain containing 1. (938 aa)
	LOC101166217	RanBP-type and C3HC4-type zinc finger containing 1. (518 aa)
	eda	Ectodysplasin A; Belongs to the tumor necrosis factor family. (364 aa)
	LOC101155616	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (424 aa)
	traf2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
	dhx9	DEAH (Asp-Glu-Ala-His) box helicase 9. (1283 aa)
	cth	Cystathionase (cystathionine gamma-lyase), like. (416 aa)
	LOC101162956	Si:dkey-181m9.8. (768 aa)
	ar-alpha	Uncharacterized protein. (687 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (590 aa)
	LOC101163515	Uncharacterized protein. (565 aa)
	LOC101166594	Ribosomal protein S6 kinase. (807 aa)
	LOC101155046	Proteasome subunit alpha type. (246 aa)
	LOC101168078	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily. (481 aa)
	LOC101171857	Component of inhibitor of nuclear factor kappa B kinase complex. (732 aa)
	LOC100049233	Androgen receptor beta subtype. (744 aa)
	H2M2N2_ORYLA	Uncharacterized protein. (150 aa)
	LOC101172593	Tumor necrosis factor a (TNF superfamily, member 2). (279 aa)
	trim8	Tripartite motif containing 8b. (594 aa)
	dhx33	DEAH (Asp-Glu-Ala-His) box polypeptide 33. (681 aa)
	LOC100144382	Eukaryotic translation initiation factor 2-alpha kinase 2. (638 aa)
	LOC101162259	Proteasome endopeptidase complex. (320 aa)
	ripk4	Receptor-interacting serine-threonine kinase 4. (813 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (765 aa)
	LOC101171170	MALT paracaspase 1. (811 aa)
	LOC101157726	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (465 aa)
	trappc9	Trafficking protein particle complex 9. (1135 aa)
	LOC101174057	Uncharacterized protein. (1112 aa)
	card11	Caspase recruitment domain family, member 11. (1146 aa)
	prdx3	Peroxiredoxin 3. (249 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (252 aa)
	LOC101159531	Tumor necrosis factor b (TNF superfamily, member 2). (247 aa)
	LOC101167626	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
	Grem1	Gremlin 1a, DAN family BMP antagonist. (165 aa)
	LOC110016550	Eukaryotic translation initiation factor 2-alpha kinase 2. (678 aa)
	arhgef2	Rho/rac guanine nucleotide exchange factor (GEF) 2. (896 aa)
	LOC101155382	Uncharacterized protein. (1085 aa)
	terf2ip	Uncharacterized protein. (682 aa)
	prkcz	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (600 aa)
	LOC101168038	Protein kinase domain-containing protein. (509 aa)
	LOC101168285	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (415 aa)
	LOC101167564	Ribosomal protein S6 kinase. (787 aa)
	LOC101168870	E1A binding protein p300 b. (2760 aa)
	ENSORLP00000045591	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (130 aa)
	nod2	Nucleotide-binding oligomerization domain containing 2. (978 aa)
	LOC100301586	CD40 molecule, TNF receptor superfamily member 5. (305 aa)
	trim37	Tripartite motif containing 37. (947 aa)
	LOC101157195	Neurotensin. (214 aa)
	ENSORLP00000035903	Uncharacterized protein. (548 aa)
	card9	Caspase recruitment domain family, member 9. (510 aa)
	LOC101169209	Uncharacterized protein. (283 aa)
	rnf25	Ring finger protein 25. (478 aa)
	LOC101158686	MALT paracaspase 2. (843 aa)
	LOC101166698	Protein kinase domain-containing protein. (721 aa)
	trim32	Tripartite motif containing 32. (622 aa)
	LOC101158194	MALT paracaspase 3. (557 aa)
	LOC101172650	Tripartite motif containing 62, tandem duplicate 1. (475 aa)
	cib1	Calcium and integrin binding 1 (calmyrin). (189 aa)
	il1rap	Uncharacterized protein. (667 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	LOC101155367	ENSORLP00000016017	ENSORLP00000003220	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.553
CHUK	LOC101155382	ENSORLP00000016017	ENSORLP00000026609	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.554
CHUK	LOC101158194	ENSORLP00000016017	ENSORLP00000040489	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 3.	0.465
CHUK	LOC101158686	ENSORLP00000016017	ENSORLP00000039932	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 2.	0.465
CHUK	LOC101162956	ENSORLP00000016017	ENSORLP00000010289	Component of inhibitor of nuclear factor kappa B kinase complex.	Si:dkey-181m9.8.	0.554
CHUK	LOC101166217	ENSORLP00000016017	ENSORLP00000007586	Component of inhibitor of nuclear factor kappa B kinase complex.	RanBP-type and C3HC4-type zinc finger containing 1.	0.479
CHUK	LOC101166698	ENSORLP00000016017	ENSORLP00000040412	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.964
CHUK	LOC101167626	ENSORLP00000016017	ENSORLP00000020860	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.553
CHUK	LOC101168038	ENSORLP00000016017	ENSORLP00000029474	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.410
CHUK	LOC101168285	ENSORLP00000016017	ENSORLP00000029843	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.417
CHUK	LOC101171170	ENSORLP00000016017	ENSORLP00000045160	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 1.	0.944
CHUK	LOC101171857	ENSORLP00000016017	ENSORLP00000011761	Component of inhibitor of nuclear factor kappa B kinase complex.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.942
CHUK	LOC101172593	ENSORLP00000016017	ENSORLP00000013121	Component of inhibitor of nuclear factor kappa B kinase complex.	Tumor necrosis factor a (TNF superfamily, member 2).	0.836
CHUK	LOC101174057	ENSORLP00000016017	ENSORLP00000016757	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.554
CHUK	card11	ENSORLP00000016017	ENSORLP00000016969	Component of inhibitor of nuclear factor kappa B kinase complex.	Caspase recruitment domain family, member 11.	0.652
CHUK	card9	ENSORLP00000016017	ENSORLP00000036206	Component of inhibitor of nuclear factor kappa B kinase complex.	Caspase recruitment domain family, member 9.	0.909
CHUK	ikbkb	ENSORLP00000016017	ENSORLP00000003065	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.953
CHUK	ripk4	ENSORLP00000016017	ENSORLP00000015653	Component of inhibitor of nuclear factor kappa B kinase complex.	Receptor-interacting serine-threonine kinase 4.	0.680
CHUK	traf2	ENSORLP00000016017	ENSORLP00000008989	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.553
CHUK	traf6	ENSORLP00000016017	ENSORLP00000001290	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.983