(19 nodes) Pharyngeal system development network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nkx2-5	Homeobox domain-containing protein. (319 aa)
	rad21	Uncharacterized protein. (636 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1056 aa)
	ENSORLP00000044390	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (1450 aa)
	LOC101172686	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (445 aa)
	LOC105357487	Activin_recp domain-containing protein. (762 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	KCTD15	Potassium channel tetramerization domain containing 15. (270 aa)
	ENSORLP00000039466	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (1375 aa)
	barx1	BARX homeobox 1. (240 aa)
	LOC101160830	Uncharacterized protein. (259 aa)
	LOC101167461	NK3 homeobox 1. (188 aa)
	ENSORLP00000034403	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (1540 aa)
	LOC101160003	Mothers against decapentaplegic homolog. (464 aa)
	dlx2	Homeobox domain-containing protein. (277 aa)
	tbx1	T-box transcription factor 1. (503 aa)
	LOC101173147	RAD21 cohesin complex component like 1. (539 aa)
	edn1	Endothelin 1. (220 aa)
	ednra	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (439 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101160003	LOC105357487	ENSORLP00000030196	ENSORLP00000042845	Mothers against decapentaplegic homolog.	Activin_recp domain-containing protein.	0.591
LOC101160003	bmpr2	ENSORLP00000030196	ENSORLP00000003793	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.591
LOC101160830	nkx2-5	ENSORLP00000036448	ENSORLP00000009208	Uncharacterized protein.	Homeobox domain-containing protein.	0.450
LOC101172686	edn1	ENSORLP00000044245	ENSORLP00000011633	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.997
LOC101172686	ednra	ENSORLP00000044245	ENSORLP00000009301	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.903
LOC101173147	rad21	ENSORLP00000018323	ENSORLP00000006967	RAD21 cohesin complex component like 1.	Uncharacterized protein.	0.904
LOC105357487	LOC101160003	ENSORLP00000042845	ENSORLP00000030196	Activin_recp domain-containing protein.	Mothers against decapentaplegic homolog.	0.591
barx1	ednra	ENSORLP00000037181	ENSORLP00000009301	BARX homeobox 1.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.443
barx1	fgf8	ENSORLP00000037181	ENSORLP00000042553	BARX homeobox 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.470
bmpr2	LOC101160003	ENSORLP00000003793	ENSORLP00000030196	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.591
dlx2	ednra	ENSORLP00000021730	ENSORLP00000009301	Homeobox domain-containing protein.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.407
dlx2	fgf8	ENSORLP00000021730	ENSORLP00000042553	Homeobox domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.534
edn1	LOC101172686	ENSORLP00000011633	ENSORLP00000044245	Endothelin 1.	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	0.997
edn1	ednra	ENSORLP00000011633	ENSORLP00000009301	Endothelin 1.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.998
edn1	fgf8	ENSORLP00000011633	ENSORLP00000042553	Endothelin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.559
ednra	LOC101172686	ENSORLP00000009301	ENSORLP00000044245	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	0.903
ednra	barx1	ENSORLP00000009301	ENSORLP00000037181	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	BARX homeobox 1.	0.443
ednra	dlx2	ENSORLP00000009301	ENSORLP00000021730	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	Homeobox domain-containing protein.	0.407
ednra	edn1	ENSORLP00000009301	ENSORLP00000011633	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.998
fgf8	barx1	ENSORLP00000042553	ENSORLP00000037181	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	BARX homeobox 1.	0.470