(55 nodes) Heart contraction network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101174831	Troponin C type 1a (slow). (161 aa)
	strip1	Striatin interacting protein 1. (844 aa)
	washc5	WASH complex subunit 5. (1159 aa)
	H2L4B7_ORYLA	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (737 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1023 aa)
	LOC101155425	Troponin I type 2a (skeletal, fast), tandem duplicate 1. (178 aa)
	csrp3	Cysteine and glycine-rich protein 3 (cardiac LIM protein). (193 aa)
	rangrf	RAN guanine nucleotide release factor. (188 aa)
	lrrc39	Leucine rich repeat containing 39. (334 aa)
	LOC101159505	Titin-cap (telethonin). (179 aa)
	LOC101172654	Uncharacterized protein. (189 aa)
	gper1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	alpk2	Uncharacterized protein. (1429 aa)
	H2LQV6_ORYLA	Uncharacterized protein. (160 aa)
	LOC101156569	Troponin I type 1b (skeletal, slow). (185 aa)
	nkx2-5	Homeobox domain-containing protein. (319 aa)
	scn3b	Sodium channel, voltage-gated, type III, beta. (216 aa)
	nup155	Nucleoporin 155. (1368 aa)
	H2LWG8_ORYLA	Troponin I type 1a (skeletal, slow). (165 aa)
	LOC101159760	Ig-like domain-containing protein. (235 aa)
	LOC101159335	SET and MYND domain containing 2a. (435 aa)
	LOC101169720	Sodium channel, voltage-gated, type IV, beta a. (232 aa)
	apex1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (311 aa)
	sgcg	Sarcoglycan, gamma. (290 aa)
	smyd2	SET and MYND domain containing 2b. (447 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	MYL2	Myosin, light chain 2b, regulatory, cardiac, slow. (168 aa)
	ccm2	CCM2 scaffold protein. (461 aa)
	slc2a12	Solute carrier family 2 member 12; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (575 aa)
	LOC101162070	Sodium channel, voltage-gated, type I, beta a. (275 aa)
	H2MTE5_ORYLA	Myosin, light chain 13. (154 aa)
	krit1	KRIT1 ankyrin repeat containing. (740 aa)
	hand2	Heart and neural crest derivatives expressed 2. (232 aa)
	MYL2-2	Myosin light chain 2. (169 aa)
	TNNI2	Troponin I2, fast skeletal type. (214 aa)
	taz	Tafazzin family protein; Belongs to the taffazin family. (262 aa)
	ext2	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa)
	dnd1	Dead end protein. (372 aa)
	LOC101161235	Troponin I4b, tandem duplicate 2. (180 aa)
	SGCZ	Sarcoglycan zeta. (324 aa)
	bves	Blood vessel epicardial substance. (356 aa)
	ENSORLP00000033307	Uncharacterized protein. (126 aa)
	kcne4	Potassium voltage-gated channel, Isk-related family, member 4. (176 aa)
	LOC101166715	Uncharacterized protein; Belongs to the potassium channel family. (719 aa)
	LOC101171376	Asp-B-Hydro_N domain-containing protein. (1349 aa)
	LOC101171215	Troponin C type 1b (slow). (161 aa)
	LOC101164098	Uncharacterized protein. (311 aa)
	vegfb	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (237 aa)
	scn2b	Sodium channel, voltage-gated, type II, beta. (220 aa)
	myl7	Uncharacterized protein. (175 aa)
	LOC101167333	Uncharacterized protein. (174 aa)
	sgcd	Sarcoglycan, delta (dystrophin-associated glycoprotein). (311 aa)
	LOC101172899	Troponin I4a. (178 aa)
	LOC101155923	Uncharacterized protein. (172 aa)
	LOC101161541	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (695 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000033307	LOC101161541	ENSORLP00000033307	ENSORLP00000043809	Uncharacterized protein.	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family.	0.978
ENSORLP00000033307	LOC101166715	ENSORLP00000033307	ENSORLP00000034183	Uncharacterized protein.	Uncharacterized protein; Belongs to the potassium channel family.	0.978
ENSORLP00000033307	kcne4	ENSORLP00000033307	ENSORLP00000033716	Uncharacterized protein.	Potassium voltage-gated channel, Isk-related family, member 4.	0.461
H2L4B7_ORYLA	Mtor	ENSORLP00000000606	ENSORLP00000000608	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.968
H2L4B7_ORYLA	atg5	ENSORLP00000000606	ENSORLP00000019636	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.459
H2LQV6_ORYLA	H2LWG8_ORYLA	ENSORLP00000008451	ENSORLP00000010456	Uncharacterized protein.	Troponin I type 1a (skeletal, slow).	0.705
H2LQV6_ORYLA	H2MTE5_ORYLA	ENSORLP00000008451	ENSORLP00000022044	Uncharacterized protein.	Myosin, light chain 13.	0.901
H2LQV6_ORYLA	LOC101155425	ENSORLP00000008451	ENSORLP00000000672	Uncharacterized protein.	Troponin I type 2a (skeletal, fast), tandem duplicate 1.	0.625
H2LQV6_ORYLA	LOC101155923	ENSORLP00000008451	ENSORLP00000043338	Uncharacterized protein.	Uncharacterized protein.	0.625
H2LQV6_ORYLA	LOC101156569	ENSORLP00000008451	ENSORLP00000008781	Uncharacterized protein.	Troponin I type 1b (skeletal, slow).	0.705
H2LQV6_ORYLA	LOC101159505	ENSORLP00000008451	ENSORLP00000004223	Uncharacterized protein.	Titin-cap (telethonin).	0.463
H2LQV6_ORYLA	LOC101161235	ENSORLP00000008451	ENSORLP00000029971	Uncharacterized protein.	Troponin I4b, tandem duplicate 2.	0.615
H2LQV6_ORYLA	LOC101167333	ENSORLP00000008451	ENSORLP00000041621	Uncharacterized protein.	Uncharacterized protein.	0.544
H2LQV6_ORYLA	LOC101171215	ENSORLP00000008451	ENSORLP00000035366	Uncharacterized protein.	Troponin C type 1b (slow).	0.665
H2LQV6_ORYLA	LOC101172654	ENSORLP00000008451	ENSORLP00000004603	Uncharacterized protein.	Uncharacterized protein.	0.615
H2LQV6_ORYLA	LOC101172899	ENSORLP00000008451	ENSORLP00000042688	Uncharacterized protein.	Troponin I4a.	0.615
H2LQV6_ORYLA	LOC101174831	ENSORLP00000008451	ENSORLP00000043852	Uncharacterized protein.	Troponin C type 1a (slow).	0.665
H2LQV6_ORYLA	MYL2	ENSORLP00000008451	ENSORLP00000019980	Uncharacterized protein.	Myosin, light chain 2b, regulatory, cardiac, slow.	0.973
H2LQV6_ORYLA	MYL2-2	ENSORLP00000008451	ENSORLP00000027432	Uncharacterized protein.	Myosin light chain 2.	0.973
H2LQV6_ORYLA	TNNI2	ENSORLP00000008451	ENSORLP00000027730	Uncharacterized protein.	Troponin I2, fast skeletal type.	0.625