(17 nodes) Regulation of necroptotic process network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MUTYH	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (522 aa)
	fadd	Uncharacterized protein. (192 aa)
	adprhl2	ADP-ribosylhydrolase like 2. (378 aa)
	LOC101168449	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family. (769 aa)
	LOC101168285	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (415 aa)
	LOC101168038	Protein kinase domain-containing protein. (509 aa)
	LOC101155382	Uncharacterized protein. (1085 aa)
	cflar	FLICE-like inhibitory protein; Belongs to the peptidase C14A family. (460 aa)
	LOC101163809	Cylindromatosis (turban tumor syndrome), b. (707 aa)
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (918 aa)
	LOC101174057	Uncharacterized protein. (1112 aa)
	casp8	Uncharacterized protein; Belongs to the peptidase C14A family. (481 aa)
	spata2	Spermatogenesis associated 2. (568 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (292 aa)
	LOC101168078	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily. (481 aa)
	LOC101162956	Si:dkey-181m9.8. (768 aa)
	LOC101166217	RanBP-type and C3HC4-type zinc finger containing 1. (518 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP6	LOC101168038	ENSORLP00000044560	ENSORLP00000029474	Caspase 6; Belongs to the peptidase C14A family.	Protein kinase domain-containing protein.	0.460
CASP6	LOC101168078	ENSORLP00000044560	ENSORLP00000011349	Caspase 6; Belongs to the peptidase C14A family.	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily.	0.460
CASP6	LOC101168285	ENSORLP00000044560	ENSORLP00000029843	Caspase 6; Belongs to the peptidase C14A family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.460
CASP6	casp8	ENSORLP00000044560	ENSORLP00000014046	Caspase 6; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.976
CASP6	fadd	ENSORLP00000044560	ENSORLP00000043356	Caspase 6; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.551
LOC101155382	LOC101162956	ENSORLP00000026609	ENSORLP00000010289	Uncharacterized protein.	Si:dkey-181m9.8.	0.904
LOC101155382	LOC101163809	ENSORLP00000026609	ENSORLP00000017400	Uncharacterized protein.	Cylindromatosis (turban tumor syndrome), b.	0.724
LOC101155382	LOC101166217	ENSORLP00000026609	ENSORLP00000007586	Uncharacterized protein.	RanBP-type and C3HC4-type zinc finger containing 1.	0.989
LOC101155382	LOC101168449	ENSORLP00000026609	ENSORLP00000036637	Uncharacterized protein.	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family.	0.724
LOC101155382	LOC101174057	ENSORLP00000026609	ENSORLP00000016757	Uncharacterized protein.	Uncharacterized protein.	0.902
LOC101155382	cyld	ENSORLP00000026609	ENSORLP00000017385	Uncharacterized protein.	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	0.724
LOC101155382	spata2	ENSORLP00000026609	ENSORLP00000011927	Uncharacterized protein.	Spermatogenesis associated 2.	0.922
LOC101162956	LOC101155382	ENSORLP00000010289	ENSORLP00000026609	Si:dkey-181m9.8.	Uncharacterized protein.	0.904
LOC101162956	LOC101163809	ENSORLP00000010289	ENSORLP00000017400	Si:dkey-181m9.8.	Cylindromatosis (turban tumor syndrome), b.	0.724
LOC101162956	LOC101166217	ENSORLP00000010289	ENSORLP00000007586	Si:dkey-181m9.8.	RanBP-type and C3HC4-type zinc finger containing 1.	0.988
LOC101162956	LOC101168449	ENSORLP00000010289	ENSORLP00000036637	Si:dkey-181m9.8.	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family.	0.724
LOC101162956	LOC101174057	ENSORLP00000010289	ENSORLP00000016757	Si:dkey-181m9.8.	Uncharacterized protein.	0.904
LOC101162956	cyld	ENSORLP00000010289	ENSORLP00000017385	Si:dkey-181m9.8.	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	0.724
LOC101162956	spata2	ENSORLP00000010289	ENSORLP00000011927	Si:dkey-181m9.8.	Spermatogenesis associated 2.	0.922
LOC101163809	LOC101155382	ENSORLP00000017400	ENSORLP00000026609	Cylindromatosis (turban tumor syndrome), b.	Uncharacterized protein.	0.724