(16 nodes) Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress network (Oryzias latipes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

co-expression

protein homology

Your Input:
	LOC111947333	Im:7152348. (143 aa)
	LOC101168687	Zgc:153993. (293 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (262 aa)
	atf4	BZIP domain-containing protein. (438 aa)
	LOC111949269	Uncharacterized protein. (927 aa)
	ENSORLP00000042436	RING-type domain-containing protein. (134 aa)
	tmem117	Transmembrane protein 117. (520 aa)
	LOC101168213	BCL2 associated X, apoptosis regulator a. (188 aa)
	LOC101162428	Endoplasmic reticulum to nucleus signaling 2. (963 aa)
	ern1	Uncharacterized protein. (1071 aa)
	aifm1	Apoptosis inducing factor mitochondrion associated 1. (708 aa)
	LOC101155601	CCAAT enhancer binding protein beta. (286 aa)
	bag6	BCL2 associated athanogene 6. (1195 aa)
	bcl2	BCL2 apoptosis regulator b. (202 aa)
	ENSORLP00000026830	RING-type domain-containing protein. (173 aa)
	ddit3	CCAAT/enhancer-binding protein-homologous protein. (308 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101155601	atf4	ENSORLP00000018839	ENSORLP00000040472	CCAAT enhancer binding protein beta.	BZIP domain-containing protein.	0.959
LOC101155601	ddit3	ENSORLP00000018839	ENSORLP00000030992	CCAAT enhancer binding protein beta.	CCAAT/enhancer-binding protein-homologous protein.	0.827
LOC101162428	LOC111949269	ENSORLP00000011199	ENSORLP00000042227	Endoplasmic reticulum to nucleus signaling 2.	Uncharacterized protein.	0.540
LOC101162428	ern1	ENSORLP00000011199	ENSORLP00000011214	Endoplasmic reticulum to nucleus signaling 2.	Uncharacterized protein.	0.902
LOC101168213	LOC101168687	ENSORLP00000005745	ENSORLP00000040142	BCL2 associated X, apoptosis regulator a.	Zgc:153993.	0.977
LOC101168213	aifm1	ENSORLP00000005745	ENSORLP00000012070	BCL2 associated X, apoptosis regulator a.	Apoptosis inducing factor mitochondrion associated 1.	0.920
LOC101168213	bcl2	ENSORLP00000005745	ENSORLP00000021005	BCL2 associated X, apoptosis regulator a.	BCL2 apoptosis regulator b.	0.808
LOC101168687	LOC101168213	ENSORLP00000040142	ENSORLP00000005745	Zgc:153993.	BCL2 associated X, apoptosis regulator a.	0.977
LOC101168687	aifm1	ENSORLP00000040142	ENSORLP00000012070	Zgc:153993.	Apoptosis inducing factor mitochondrion associated 1.	0.936
LOC101168687	bcl2	ENSORLP00000040142	ENSORLP00000021005	Zgc:153993.	BCL2 apoptosis regulator b.	0.856
LOC111949269	LOC101162428	ENSORLP00000042227	ENSORLP00000011199	Uncharacterized protein.	Endoplasmic reticulum to nucleus signaling 2.	0.540
LOC111949269	ern1	ENSORLP00000042227	ENSORLP00000011214	Uncharacterized protein.	Uncharacterized protein.	0.540
aifm1	LOC101168213	ENSORLP00000012070	ENSORLP00000005745	Apoptosis inducing factor mitochondrion associated 1.	BCL2 associated X, apoptosis regulator a.	0.920
aifm1	LOC101168687	ENSORLP00000012070	ENSORLP00000040142	Apoptosis inducing factor mitochondrion associated 1.	Zgc:153993.	0.936
atf4	LOC101155601	ENSORLP00000040472	ENSORLP00000018839	BZIP domain-containing protein.	CCAAT enhancer binding protein beta.	0.959
atf4	bcl2	ENSORLP00000040472	ENSORLP00000021005	BZIP domain-containing protein.	BCL2 apoptosis regulator b.	0.461
atf4	ddit3	ENSORLP00000040472	ENSORLP00000030992	BZIP domain-containing protein.	CCAAT/enhancer-binding protein-homologous protein.	0.845
atf4	ern1	ENSORLP00000040472	ENSORLP00000011214	BZIP domain-containing protein.	Uncharacterized protein.	0.605
bcl2	LOC101168213	ENSORLP00000021005	ENSORLP00000005745	BCL2 apoptosis regulator b.	BCL2 associated X, apoptosis regulator a.	0.808
bcl2	LOC101168687	ENSORLP00000021005	ENSORLP00000040142	BCL2 apoptosis regulator b.	Zgc:153993.	0.856