(55 nodes) Bicellular tight junction assembly network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2L4Q8_ORYLA	Uncharacterized protein. (259 aa)
	LOC101163423	MARVEL domain containing 2a. (556 aa)
	LOC101166566	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	LOC101174288	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (781 aa)
	LOC101159211	Uncharacterized protein. (172 aa)
	H2L717_ORYLA	Uncharacterized protein. (182 aa)
	H2L737_ORYLA	Uncharacterized protein. (151 aa)
	LOC101156223	Si:dkey-237i9.8. (782 aa)
	pard3	Par-3 family cell polarity regulator alpha, b. (1389 aa)
	frmpd2	FERM and PDZ domain containing 2. (776 aa)
	H2LCI4_ORYLA	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (271 aa)
	H2LCK0_ORYLA	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (198 aa)
	H2LCK1_ORYLA	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (109 aa)
	H2LCK7_ORYLA	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (201 aa)
	H2LE16_ORYLA	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (275 aa)
	H2LE26_ORYLA	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (256 aa)
	H2LE29_ORYLA	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
	LOC101161011	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
	LOC101172061	Si:busm1-52i16.2. (343 aa)
	LOC101156528	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (212 aa)
	LOC101165395	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	tbcd	Tubulin folding cofactor D. (1195 aa)
	LOC101158790	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (212 aa)
	H2M6P6_ORYLA	Claudin 23a. (252 aa)
	pdcd6ip	Programmed cell death 6 interacting protein. (882 aa)
	LOC101159590	Platelet/endothelial cell adhesion molecule 1. (793 aa)
	cldn19	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
	srf	Serum response factor b. (611 aa)
	marveld2	MARVEL domain containing 2b. (583 aa)
	CLDN20	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (242 aa)
	LOC101155569	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
	Cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (109 aa)
	LOC101166512	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (254 aa)
	pof1b	POF1B actin binding protein. (659 aa)
	LOC101167443	Si:ch211-191a24.4. (282 aa)
	ect2	Epithelial cell transforming 2. (1098 aa)
	ENSORLP00000031308	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
	bves	Blood vessel epicardial substance. (356 aa)
	LOC105358811	MADS-box domain-containing protein. (552 aa)
	PARD3	Par-3 family cell polarity regulator. (1373 aa)
	ENSORLP00000033296	Claudin b. (205 aa)
	rab13	Uncharacterized protein. (242 aa)
	LOC101167197	Si:ch211-191a24.4. (360 aa)
	LOC101169249	Non-specific serine/threonine protein kinase. (514 aa)
	afdn	Afadin, adherens junction formation factor a. (1700 aa)
	ENSORLP00000039435	PDZ domain-containing protein. (523 aa)
	pak2	Non-specific serine/threonine protein kinase. (532 aa)
	ENSORLP00000039963	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (174 aa)
	LOC101169436	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (545 aa)
	ENSORLP00000042011	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
	arl2	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family. (184 aa)
	ENSORLP00000042461	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (180 aa)
	LOC101163673	Occludin a. (497 aa)
	LOC101155470	Uncharacterized protein. (210 aa)
	esam	Endothelial cell adhesion molecule a. (451 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLDN20	Cldn5	ENSORLP00000021675	ENSORLP00000026956	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.667
CLDN20	ENSORLP00000031308	ENSORLP00000021675	ENSORLP00000031308	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.659
CLDN20	ENSORLP00000033296	ENSORLP00000021675	ENSORLP00000033296	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin b.	0.657
CLDN20	ENSORLP00000042011	ENSORLP00000021675	ENSORLP00000042011	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
CLDN20	ENSORLP00000042461	ENSORLP00000021675	ENSORLP00000042461	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.677
CLDN20	H2L717_ORYLA	ENSORLP00000021675	ENSORLP00000001625	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.667
CLDN20	H2L737_ORYLA	ENSORLP00000021675	ENSORLP00000001645	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.657
CLDN20	H2LCI4_ORYLA	ENSORLP00000021675	ENSORLP00000003622	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
CLDN20	H2LCK1_ORYLA	ENSORLP00000021675	ENSORLP00000003640	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
CLDN20	H2LCK7_ORYLA	ENSORLP00000021675	ENSORLP00000003646	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
CLDN20	H2LE26_ORYLA	ENSORLP00000021675	ENSORLP00000004193	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.667
CLDN20	H2LE29_ORYLA	ENSORLP00000021675	ENSORLP00000004196	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.691
CLDN20	H2M6P6_ORYLA	ENSORLP00000021675	ENSORLP00000014143	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin 23a.	0.737
CLDN20	LOC101155569	ENSORLP00000021675	ENSORLP00000025334	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.667
CLDN20	LOC101156528	ENSORLP00000021675	ENSORLP00000005747	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.670
CLDN20	LOC101158790	ENSORLP00000021675	ENSORLP00000012777	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.667
CLDN20	LOC101159211	ENSORLP00000021675	ENSORLP00000001623	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.667
CLDN20	LOC101161011	ENSORLP00000021675	ENSORLP00000004406	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.667
CLDN20	LOC101165395	ENSORLP00000021675	ENSORLP00000008977	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.657
CLDN20	LOC101166566	ENSORLP00000021675	ENSORLP00000001336	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.670