(23 nodes) Stem cell proliferation network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ETV6	ETS variant 6. (602 aa)
	H2MJT0_ORYLA	Uncharacterized protein. (589 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (725 aa)
	cep120	Centrosomal protein 120. (974 aa)
	Nf1	Uncharacterized protein. (506 aa)
	ercc2	Excision repair cross-complementation group 2. (761 aa)
	cdkn2c	Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (168 aa)
	lig4	DNA ligase. (912 aa)
	brca2	BRCA2 DNA repair associated. (3161 aa)
	trim71	Tripartite motif containing 71, E3 ubiquitin protein ligase. (826 aa)
	znrf3	Zinc and ring finger 3. (871 aa)
	rnf43	Ring finger protein 43. (856 aa)
	kdf1	Keratinocyte differentiation factor 1a. (391 aa)
	mecom	MDS1 and EVI1 complex locus. (1234 aa)
	ism1	Isthmin 1. (453 aa)
	LOC101171428	FZ domain-containing protein. (337 aa)
	ythdf2	YTH N(6)-methyladenosine RNA binding protein 2. (636 aa)
	sfrp2	Secreted frizzled-related protein 2. (290 aa)
	mettl3	Methyltransferase like 3; Belongs to the MT-A70-like family. (584 aa)
	arih2	RBR-type E3 ubiquitin transferase. (509 aa)
	LOC101157631	Transforming growth factor beta; Belongs to the TGF-beta family. (444 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	bysl	Bystin-like. (437 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2MJT0_ORYLA	Nf1	ENSORLP00000018929	ENSORLP00000026133	Uncharacterized protein.	Uncharacterized protein.	0.943
H2MJT0_ORYLA	brca2	ENSORLP00000018929	ENSORLP00000039367	Uncharacterized protein.	BRCA2 DNA repair associated.	0.409
LOC101157631	fgf4	ENSORLP00000001563	ENSORLP00000000362	Transforming growth factor beta; Belongs to the TGF-beta family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.561
Nf1	H2MJT0_ORYLA	ENSORLP00000026133	ENSORLP00000018929	Uncharacterized protein.	Uncharacterized protein.	0.943
Nf1	brca2	ENSORLP00000026133	ENSORLP00000039367	Uncharacterized protein.	BRCA2 DNA repair associated.	0.409
brca2	H2MJT0_ORYLA	ENSORLP00000039367	ENSORLP00000018929	BRCA2 DNA repair associated.	Uncharacterized protein.	0.409
brca2	Nf1	ENSORLP00000039367	ENSORLP00000026133	BRCA2 DNA repair associated.	Uncharacterized protein.	0.409
brca2	ercc2	ENSORLP00000039367	ENSORLP00000032234	BRCA2 DNA repair associated.	Excision repair cross-complementation group 2.	0.635
brca2	lig4	ENSORLP00000039367	ENSORLP00000037330	BRCA2 DNA repair associated.	DNA ligase.	0.680
brca2	xrcc5	ENSORLP00000039367	ENSORLP00000020528	BRCA2 DNA repair associated.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.560
ercc2	brca2	ENSORLP00000032234	ENSORLP00000039367	Excision repair cross-complementation group 2.	BRCA2 DNA repair associated.	0.635
ercc2	lig4	ENSORLP00000032234	ENSORLP00000037330	Excision repair cross-complementation group 2.	DNA ligase.	0.610
ercc2	xrcc5	ENSORLP00000032234	ENSORLP00000020528	Excision repair cross-complementation group 2.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.561
fgf4	LOC101157631	ENSORLP00000000362	ENSORLP00000001563	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.561
lig4	brca2	ENSORLP00000037330	ENSORLP00000039367	DNA ligase.	BRCA2 DNA repair associated.	0.680
lig4	ercc2	ENSORLP00000037330	ENSORLP00000032234	DNA ligase.	Excision repair cross-complementation group 2.	0.610
lig4	xrcc5	ENSORLP00000037330	ENSORLP00000020528	DNA ligase.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.984
mettl3	ythdf2	ENSORLP00000009027	ENSORLP00000017958	Methyltransferase like 3; Belongs to the MT-A70-like family.	YTH N(6)-methyladenosine RNA binding protein 2.	0.585
rnf43	znrf3	ENSORLP00000044600	ENSORLP00000044251	Ring finger protein 43.	Zinc and ring finger 3.	0.794
xrcc5	brca2	ENSORLP00000020528	ENSORLP00000039367	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	BRCA2 DNA repair associated.	0.560