(89 nodes) Epithelial tube formation network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ift52	Intraflagellar transport 52 homolog (Chlamydomonas). (433 aa)
	TSC2	TSC complex subunit 2. (1608 aa)
	mpp5	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (646 aa)
	H2MA54_ORYLA	Uncharacterized protein. (489 aa)
	H2ME95_ORYLA	Lysine (K)-specific demethylase 6A. (806 aa)
	irx3	Iroquois homeobox 3a. (423 aa)
	efhc2	EF-hand domain (C-terminal) containing 2. (734 aa)
	dvl3	Dishevelled segment polarity protein 3a. (685 aa)
	LOC101155782	Iroquois homeobox 1b. (452 aa)
	tsc1	TSC complex subunit 1b. (1198 aa)
	mks1	MKS transition zone complex subunit 1. (563 aa)
	mthfd1l	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (966 aa)
	LOC101160964	Uncharacterized protein; Belongs to the protein kinase superfamily. (359 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (191 aa)
	H2MLV1_ORYLA	Uncharacterized protein. (141 aa)
	sall4	Spalt-like transcription factor 4. (1059 aa)
	spint1	Serine peptidase inhibitor, Kunitz type 1 a. (503 aa)
	LOC101174548	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (881 aa)
	gata3	Uncharacterized protein. (440 aa)
	Grem1	Gremlin 1a, DAN family BMP antagonist. (165 aa)
	mdn1	Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5172 aa)
	prkci	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (554 aa)
	LOC101164937	Coiled-coil domain containing 88C. (1911 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	mthfr	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (657 aa)
	abl2	Tyrosine-protein kinase. (1185 aa)
	MPP5	Membrane palmitoylated protein 5; Belongs to the MAGUK family. (667 aa)
	hand2	Heart and neural crest derivatives expressed 2. (232 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1072 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
	dvl2	Dishevelled segment polarity protein 2. (770 aa)
	LOC101161906	Transmembrane p24 trafficking protein 2. (207 aa)
	ret	Ret proto-oncogene receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1144 aa)
	ENSORLP00000029707	Uncharacterized protein. (166 aa)
	ENSORLP00000029802	Uncharacterized protein. (470 aa)
	LOC101160003	Mothers against decapentaplegic homolog. (464 aa)
	LOC101154972	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	Cep290	Uncharacterized protein. (169 aa)
	ENSORLP00000031311	Uncharacterized protein. (248 aa)
	LOC101175207	Serine peptidase inhibitor, Kunitz type 1 a. (493 aa)
	ENSORLP00000031792	MANSC domain-containing protein. (197 aa)
	Tsc2	DUF3384 domain-containing protein. (164 aa)
	LOC101163742	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (377 aa)
	setd2	SET domain containing 2, histone lysine methyltransferase. (2587 aa)
	pax2	Paired box 2b. (387 aa)
	ENSORLP00000039316	Uncharacterized protein. (281 aa)
	tctn1	DUF1619 domain-containing protein. (607 aa)
	LOC101166746	Phosphatase and actin regulator. (584 aa)
	ENSORLP00000040334	Uncharacterized protein. (273 aa)
	phactr4	Phosphatase and actin regulator. (836 aa)
	pax8	Paired box 8. (444 aa)
	LOC101155219	Paired domain-containing protein. (485 aa)
	hectd1	HECT domain containing 1. (2529 aa)
	deaf1	DEAF1 transcription factor. (545 aa)
	abl1	Tyrosine-protein kinase. (1106 aa)
	dvl1	Dishevelled segment polarity protein 1a. (728 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	hs2st1	Heparan sulfate 2-O-sulfotransferase 1a. (357 aa)
	LOC101165777	Podocalyxin-like. (419 aa)
	LOC101165469	Phosphatase and actin regulator. (622 aa)
	LOC101160234	Bromo domain-containing protein. (1556 aa)
	ENSORLP00000044416	Uncharacterized protein. (670 aa)
	LOC101170876	Uncharacterized protein; Belongs to the protein kinase superfamily. (354 aa)
	LOC101162949	Iroquois homeobox 1a. (500 aa)
	glmn	Glomulin, FKBP associated protein a. (588 aa)
	LOC101161131	Lysine (K)-specific demethylase 6A, like. (1465 aa)
	hnf1b	HNF1 homeobox Ba. (555 aa)
	dlx5	Distal-less homeobox 5a. (296 aa)
	dlx6	Distal-less homeobox 6a. (246 aa)
	dlx3	Distal-less homeobox 3b. (278 aa)
	LOC101159505	Titin-cap (telethonin). (179 aa)
	H2LDU0_ORYLA	Paired domain-containing protein. (140 aa)
	VANGL2	Vang-like protein. (525 aa)
	cthrc1	Collagen triple helix repeat containing 1b. (229 aa)
	LOC101173693	Heparan sulfate 2-O-sulfotransferase 1b. (357 aa)
	ccdc85b	Coiled-coil domain containing 85B. (200 aa)
	fst	Follistatin a. (321 aa)
	bbs4	Bardet-Biedl syndrome 4. (535 aa)
	LOC101157631	Transforming growth factor beta; Belongs to the TGF-beta family. (444 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
	LOC101165094	Cordon-bleu WH2 repeat protein. (1444 aa)
	pax5	Paired box 5. (396 aa)
	tctn3	DUF1619 domain-containing protein. (608 aa)
	sfrp2	Secreted frizzled-related protein 2. (290 aa)
	LOC101162937	Phosphatase and actin regulator 4a. (1122 aa)
	chrd	Chordin; Belongs to the chordin family. (946 aa)
	bmp2	TGF_BETA_2 domain-containing protein. (413 aa)
	lrrc1	Leucine rich repeat containing 1. (497 aa)
	LOC101171428	FZ domain-containing protein. (337 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cep290	ENSORLP00000044416	ENSORLP00000030935	ENSORLP00000044416	Uncharacterized protein.	Uncharacterized protein.	0.943
Cep290	bbs4	ENSORLP00000030935	ENSORLP00000002011	Uncharacterized protein.	Bardet-Biedl syndrome 4.	0.472
Cep290	mks1	ENSORLP00000030935	ENSORLP00000018083	Uncharacterized protein.	MKS transition zone complex subunit 1.	0.420
ENSORLP00000029707	ENSORLP00000044416	ENSORLP00000029707	ENSORLP00000044416	Uncharacterized protein.	Uncharacterized protein.	0.943
ENSORLP00000029707	bbs4	ENSORLP00000029707	ENSORLP00000002011	Uncharacterized protein.	Bardet-Biedl syndrome 4.	0.472
ENSORLP00000029707	mks1	ENSORLP00000029707	ENSORLP00000018083	Uncharacterized protein.	MKS transition zone complex subunit 1.	0.420
ENSORLP00000031311	ENSORLP00000039316	ENSORLP00000031311	ENSORLP00000039316	Uncharacterized protein.	Uncharacterized protein.	0.739
ENSORLP00000031311	H2ME95_ORYLA	ENSORLP00000031311	ENSORLP00000016899	Uncharacterized protein.	Lysine (K)-specific demethylase 6A.	0.739
ENSORLP00000031311	LOC101161131	ENSORLP00000031311	ENSORLP00000006127	Uncharacterized protein.	Lysine (K)-specific demethylase 6A, like.	0.739
ENSORLP00000031311	TSC2	ENSORLP00000031311	ENSORLP00000014632	Uncharacterized protein.	TSC complex subunit 2.	0.968
ENSORLP00000031311	Tsc2	ENSORLP00000031311	ENSORLP00000032706	Uncharacterized protein.	DUF3384 domain-containing protein.	0.993
ENSORLP00000031311	bbs4	ENSORLP00000031311	ENSORLP00000002011	Uncharacterized protein.	Bardet-Biedl syndrome 4.	0.408
ENSORLP00000031311	tsc1	ENSORLP00000031311	ENSORLP00000018027	Uncharacterized protein.	TSC complex subunit 1b.	0.545
ENSORLP00000039316	ENSORLP00000031311	ENSORLP00000039316	ENSORLP00000031311	Uncharacterized protein.	Uncharacterized protein.	0.739
ENSORLP00000039316	H2ME95_ORYLA	ENSORLP00000039316	ENSORLP00000016899	Uncharacterized protein.	Lysine (K)-specific demethylase 6A.	0.970
ENSORLP00000039316	LOC101161131	ENSORLP00000039316	ENSORLP00000006127	Uncharacterized protein.	Lysine (K)-specific demethylase 6A, like.	0.657
ENSORLP00000039316	ift52	ENSORLP00000039316	ENSORLP00000014623	Uncharacterized protein.	Intraflagellar transport 52 homolog (Chlamydomonas).	0.543
ENSORLP00000039316	setd2	ENSORLP00000039316	ENSORLP00000037572	Uncharacterized protein.	SET domain containing 2, histone lysine methyltransferase.	0.727
ENSORLP00000039316	tsc1	ENSORLP00000039316	ENSORLP00000018027	Uncharacterized protein.	TSC complex subunit 1b.	0.739
ENSORLP00000040334	mthfr	ENSORLP00000040334	ENSORLP00000023652	Uncharacterized protein.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.635