(67 nodes) Positive regulation of canonical Wnt signaling pathway network (Oryzias latipes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101160793	Transmembrane protein 198b. (362 aa)
	csnk1g1	Casein kinase 1, gamma 1; Belongs to the protein kinase superfamily. (472 aa)
	USP34	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (2781 aa)
	LOC105356509	Casein kinase 1, epsilon; Belongs to the protein kinase superfamily. (416 aa)
	usp8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1078 aa)
	ILK	Integrin linked kinase. (452 aa)
	bambi	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (257 aa)
	ppm1b	Protein phosphatase, Mg2+/Mn2+ dependent, 1Ba. (402 aa)
	LOC101172012	Uncharacterized protein. (452 aa)
	LOC101168937	Ring finger protein 220b. (554 aa)
	FAM53B	Uncharacterized protein. (448 aa)
	RNF146	Ring finger protein 146. (375 aa)
	eda	Ectodysplasin A; Belongs to the tumor necrosis factor family. (364 aa)
	LOC101159369	Protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative). (447 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1365 aa)
	LOC101171257	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
	sfrp2	Secreted frizzled-related protein 2. (290 aa)
	gprc5b	G protein-coupled receptor, class C, group 5, member Ba. (400 aa)
	LOC101165003	Transducin (beta)-like 1 X-linked receptor 1b. (528 aa)
	LOC101172235	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (445 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (156 aa)
	H2M0Q7_ORYLA	APC membrane recruitment protein 1. (960 aa)
	H2M1P0_ORYLA	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (583 aa)
	LOC101156612	Protein phosphatase, Mg2+/Mn2+ dependent, 1Bb. (474 aa)
	LOC101170581	Glypican 5b; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (616 aa)
	LOC101171428	FZ domain-containing protein. (337 aa)
	adgra2	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1368 aa)
	atp6ap2	ATPase H+ transporting accessory protein 2. (374 aa)
	TBL1XR1	Uncharacterized protein. (515 aa)
	csnk1e	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (413 aa)
	rspo1	Uncharacterized protein. (270 aa)
	GID8	Uncharacterized protein. (229 aa)
	LOC101171824	DUF4203 domain-containing protein. (342 aa)
	LOC101156325	DUF4203 domain-containing protein. (334 aa)
	ppm1a	Protein phosphatase, Mg2+/Mn2+ dependent, 1Aa. (388 aa)
	H2MMT5_ORYLA	Glypican 5c; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (359 aa)
	LOC101167083	Transmembrane protein 198a. (389 aa)
	ttc21b	Tetratricopeptide repeat domain 21B. (1321 aa)
	H2MRC6_ORYLA	Ring finger protein 146. (316 aa)
	csnk1d	Casein kinase 1, delta b; Belongs to the protein kinase superfamily. (405 aa)
	LOC101170720	Transducin beta like 1 X-linked. (513 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2241 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1072 aa)
	LOC101171501	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	LOC101157048	WNK lysine deficient protein kinase 2. (2286 aa)
	CSNK1G2	Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (415 aa)
	ENSORLP00000032097	Uncharacterized protein. (189 aa)
	LOC101158122	Poly [ADP-ribose] polymerase. (1283 aa)
	LOC105356552	PH domain-containing protein. (1284 aa)
	RNF220	Uncharacterized protein. (266 aa)
	LOC101164849	Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (ctnnb1) nuclear localization. (411 aa)
	lgr5	G_PROTEIN_RECEP_F1_2 domain-containing protein. (909 aa)
	nle1	Notchless homolog 1 (Drosophila). (478 aa)
	LOC101166883	X-linked inhibitor of apoptosis. (408 aa)
	wls	Wnt ligand secretion mediator. (554 aa)
	LOC101168073	Ring finger protein 220a. (379 aa)
	ubr5	Ubiquitin protein ligase E3 component n-recognin 5. (2859 aa)
	dkk2	Dickkopf WNT signaling pathway inhibitor 2. (272 aa)
	LOC105353570	Poly [ADP-ribose] polymerase. (1266 aa)
	LOC101174248	G protein-coupled receptor, class C, group 5, member Bb. (417 aa)
	lgr4	Leucine-rich repeat containing G protein-coupled receptor 4. (975 aa)
	ENSORLP00000042326	Dickkopf_N domain-containing protein. (172 aa)
	gpc5	Glypican 5a; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (564 aa)
	PRDM15	PR/SET domain 15. (1119 aa)
	rspo2	R-spondin-2. (245 aa)
	ENSORLP00000045591	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (130 aa)
	LOC101165057	GID complex subunit 8 homolog b (S. cerevisiae). (228 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000032097	LOC101156325	ENSORLP00000032097	ENSORLP00000018952	Uncharacterized protein.	DUF4203 domain-containing protein.	0.464
ENSORLP00000032097	LOC101160793	ENSORLP00000032097	ENSORLP00000000850	Uncharacterized protein.	Transmembrane protein 198b.	0.464
ENSORLP00000032097	LOC101167083	ENSORLP00000032097	ENSORLP00000020195	Uncharacterized protein.	Transmembrane protein 198a.	0.464
ENSORLP00000032097	LOC101171824	ENSORLP00000032097	ENSORLP00000018906	Uncharacterized protein.	DUF4203 domain-containing protein.	0.464
ENSORLP00000045591	sfrp2	ENSORLP00000045591	ENSORLP00000010461	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Secreted frizzled-related protein 2.	0.498
H2MRC6_ORYLA	LOC101158122	ENSORLP00000021305	ENSORLP00000032133	Ring finger protein 146.	Poly [ADP-ribose] polymerase.	0.935
H2MRC6_ORYLA	LOC105353570	ENSORLP00000021305	ENSORLP00000041359	Ring finger protein 146.	Poly [ADP-ribose] polymerase.	0.857
H2MRC6_ORYLA	USP34	ENSORLP00000021305	ENSORLP00000002000	Ring finger protein 146.	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family.	0.520
ILK	LOC101172012	ENSORLP00000005213	ENSORLP00000005819	Integrin linked kinase.	Uncharacterized protein.	0.900
LOC101156325	ENSORLP00000032097	ENSORLP00000018952	ENSORLP00000032097	DUF4203 domain-containing protein.	Uncharacterized protein.	0.464
LOC101156325	LOC101166883	ENSORLP00000018952	ENSORLP00000039982	DUF4203 domain-containing protein.	X-linked inhibitor of apoptosis.	0.464
LOC101156612	ppm1b	ENSORLP00000012920	ENSORLP00000005662	Protein phosphatase, Mg2+/Mn2+ dependent, 1Bb.	Protein phosphatase, Mg2+/Mn2+ dependent, 1Ba.	0.901
LOC101158122	H2MRC6_ORYLA	ENSORLP00000032133	ENSORLP00000021305	Poly [ADP-ribose] polymerase.	Ring finger protein 146.	0.935
LOC101158122	RNF146	ENSORLP00000032133	ENSORLP00000007221	Poly [ADP-ribose] polymerase.	Ring finger protein 146.	0.955
LOC101158122	USP34	ENSORLP00000032133	ENSORLP00000002000	Poly [ADP-ribose] polymerase.	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family.	0.544
LOC101159369	ppm1a	ENSORLP00000008629	ENSORLP00000019753	Protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative).	Protein phosphatase, Mg2+/Mn2+ dependent, 1Aa.	0.902
LOC101160793	ENSORLP00000032097	ENSORLP00000000850	ENSORLP00000032097	Transmembrane protein 198b.	Uncharacterized protein.	0.464
LOC101160793	LOC101166883	ENSORLP00000000850	ENSORLP00000039982	Transmembrane protein 198b.	X-linked inhibitor of apoptosis.	0.464
LOC101165003	LOC101170720	ENSORLP00000011136	ENSORLP00000022345	Transducin (beta)-like 1 X-linked receptor 1b.	Transducin beta like 1 X-linked.	0.937
LOC101165003	TBL1XR1	ENSORLP00000011136	ENSORLP00000018048	Transducin (beta)-like 1 X-linked receptor 1b.	Uncharacterized protein.	0.900