STRINGSTRING
orc4 orc4 pot1 pot1 aurkb aurkb H2L4M6_ORYLA H2L4M6_ORYLA ten1 ten1 LOC101158111 LOC101158111 ppp2ca ppp2ca hells hells smc1b smc1b ncapd3 ncapd3 CLASP1 CLASP1 cenpi cenpi LOC101175126 LOC101175126 LOC101158002 LOC101158002 LOC101169945 LOC101169945 LOC101155373 LOC101155373 LOC101160693 LOC101160693 rassf2 rassf2 ercc4 ercc4 kdm4a kdm4a seh1l seh1l smg6 smg6 ZNF207 ZNF207 LOC101157951 LOC101157951 LOC101155061 LOC101155061 spout1 spout1 LOC101165696 LOC101165696 dscc1 dscc1 mtbp mtbp DCTN6 DCTN6 cenpq cenpq LOC101168655 LOC101168655 ndc80 ndc80 rad21 rad21 cenpt cenpt nudcd2 nudcd2 ncapg ncapg LOC101171445 LOC101171445 KIF18A KIF18A kntc1 kntc1 atrx atrx dclre1b dclre1b LOC101159673 LOC101159673 smc5 smc5 LOC101173928 LOC101173928 mre11 mre11 LOC101167121 LOC101167121 smc1a smc1a DYNLT3 DYNLT3 fmr1 fmr1 anapc16 anapc16 LOC101171430 LOC101171430 tpr tpr bub3 bub3 cenpn cenpn oip5 oip5 nuf2 nuf2 cdca8 cdca8 BAZ1A BAZ1A mis12 mis12 spdl1 spdl1 ahctf1 ahctf1 pold1 pold1 orc2 orc2 spo11 spo11 terf2 terf2 clasp2 clasp2 rnf8 rnf8 cenpv cenpv sgo1 sgo1 nek2 nek2 LOC101158643 LOC101158643 kdm1a kdm1a cenpk cenpk chrac1 chrac1 dctn5 dctn5 ska3 ska3 NDE1 NDE1 LOC101165590 LOC101165590 LOC101163867 LOC101163867 tert tert rangap1 rangap1 zw10 zw10 ckap5 ckap5 LOC101173147 LOC101173147 sirt6 sirt6 LOC101155601 LOC101155601 rad51d rad51d znf276 znf276 LOC101160375 LOC101160375 ppp1cc ppp1cc ercc1 ercc1 xrcc5 xrcc5 nup37 nup37 CBX1 CBX1 spc25 spc25 nup43 nup43 H2MU36_ORYLA H2MU36_ORYLA rad51 rad51 trappc12 trappc12 LOC110014793 LOC110014793 LOC111946820 LOC111946820 cfdp1 cfdp1 ska1 ska1 LOC101161711 LOC101161711 suv39h1 suv39h1 H2MZX5_ORYLA H2MZX5_ORYLA znf330 znf330 ttk ttk mad2l1 mad2l1 Rif1 Rif1 LOC101172596 LOC101172596 nsmce4a nsmce4a majin majin Atm Atm rassf4 rassf4 LOC101172197 LOC101172197 terf2ip terf2ip ENSORLP00000027107 ENSORLP00000027107 LOC101169701 LOC101169701 ENSORLP00000027619 ENSORLP00000027619 incenp incenp cenph cenph ppp2cb ppp2cb nsmce2 nsmce2 ENSORLP00000028463 ENSORLP00000028463 recql4 recql4 orc1 orc1 znf827 znf827 cenpm cenpm ENSORLP00000029827 ENSORLP00000029827 Tep1 Tep1 dhx36 dhx36 terb2 terb2 LOC100049459 LOC100049459 cbx5 cbx5 LOC101162870 LOC101162870 LOC101168459 LOC101168459 hat1 hat1 smc3 smc3 ENSORLP00000032040 ENSORLP00000032040 LOC101158122 LOC101158122 bod1l1 bod1l1 bub1 bub1 nup133 nup133 tp53bp1 tp53bp1 nsl1 nsl1 spc24 spc24 ENSORLP00000033799 ENSORLP00000033799 LOC101167464 LOC101167464 dnmt1 dnmt1 cdt1 cdt1 cenpw cenpw terf1 terf1 stn1 stn1 terb1 terb1 ENSORLP00000035938 ENSORLP00000035938 CBX1-2 CBX1-2 wrap53 wrap53 bub1b bub1b cenpf cenpf dmc1 dmc1 LOC101162552 LOC101162552 LOC101166919 LOC101166919 rec8 rec8 rad50 rad50 cenpx cenpx pinx1 pinx1 cep131 cep131 rcc2 rcc2 LOC101165555 LOC101165555 smc4 smc4 brca2 brca2 LOC101170539 LOC101170539 xrcc1 xrcc1 zwilch zwilch LOC101164346 LOC101164346 ENSORLP00000040907 ENSORLP00000040907 LOC101173508 LOC101173508 LOC105353570 LOC105353570 LOC101172442 LOC101172442 slx4 slx4 phf6 phf6 LOC101164183 LOC101164183 Ncapd2 Ncapd2 gpatch11 gpatch11 Knl1 Knl1 fbxo28 fbxo28 LOC101175080 LOC101175080 mad1l1 mad1l1 lrwd1 lrwd1 nsmce1 nsmce1 meaf6 meaf6 ska2 ska2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (433 aa)
pot1Protection of telomeres 1 homolog. (812 aa)
aurkbProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (332 aa)
H2L4M6_ORYLAUncharacterized protein. (160 aa)
ten1TEN1 subunit of CST complex. (132 aa)
LOC101158111NUDE_C domain-containing protein. (350 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
hellsHelicase, lymphoid specific. (853 aa)
smc1bStructural maintenance of chromosomes protein. (1246 aa)
ncapd3Non-SMC condensin II complex, subunit D3. (1403 aa)
CLASP1Uncharacterized protein. (1611 aa)
cenpiCentromere protein I. (731 aa)
LOC101175126Exportin 1 (CRM1 homolog, yeast) a. (1066 aa)
LOC101158002Uncharacterized protein. (114 aa)
LOC101169945Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
LOC101155373Biorientation of chromosomes in cell division 1. (167 aa)
LOC101160693Ran GTPase activating protein 1b. (564 aa)
rassf2Ras association domain family member 2a. (323 aa)
ercc4Excision repair cross-complementation group 4. (889 aa)
kdm4aLysine (K)-specific demethylase 4A, genome duplicate a. (966 aa)
seh1lSEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. (341 aa)
smg6SMG6 nonsense mediated mRNA decay factor. (1641 aa)
ZNF207Zinc finger protein 207, b. (470 aa)
LOC101157951Si:dkey-6i22.5. (229 aa)
LOC101155061Baculoviral IAP repeat containing 5a. (141 aa)
spout1SPOUT domain containing methyltransferase 1. (345 aa)
LOC101165696Lysine (K)-specific demethylase 4C. (1571 aa)
dscc1DNA replication and sister chromatid cohesion 1. (391 aa)
mtbpMDM2 binding protein. (882 aa)
DCTN6Dynactin subunit 6. (214 aa)
cenpqUncharacterized protein. (289 aa)
LOC101168655Nbl1_Borealin_N domain-containing protein. (257 aa)
ndc80NDC80 kinetochore complex component. (640 aa)
rad21Uncharacterized protein. (636 aa)
cenptCENP-T_C domain-containing protein. (866 aa)
nudcd2NudC domain containing 2. (157 aa)
ncapgNon-SMC condensin I complex, subunit G. (1034 aa)
LOC101171445Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (325 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (915 aa)
kntc1Kinetochore associated 1. (1989 aa)
atrxATRX chromatin remodeler. (2095 aa)
dclre1bDNA cross-link repair 1B. (582 aa)
LOC101159673DSN1 component of MIS12 kinetochore complex. (381 aa)
smc5Structural maintenance of chromosomes 5. (1072 aa)
LOC101173928Lysine (K)-specific demethylase 4B. (1068 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (694 aa)
LOC101167121NudE neurodevelopment protein 1-like 1b. (340 aa)
smc1aStructural maintenance of chromosomes protein. (1231 aa)
DYNLT3Uncharacterized protein. (113 aa)
fmr1Fragile X mental retardation 1. (598 aa)
anapc16Anaphase promoting complex subunit 16. (83 aa)
LOC101171430Uncharacterized protein. (1871 aa)
tprTranslocated promoter region b, nuclear basket protein. (2165 aa)
bub3BUB3 mitotic checkpoint protein. (326 aa)
cenpnCentromere protein N. (345 aa)
oip5Opa interacting protein 5. (216 aa)
nuf2UF2 component of NDC80 kinetochore complex. (454 aa)
cdca8Cell division cycle associated 8. (397 aa)
BAZ1ABromodomain adjacent to zinc finger domain 1A. (1452 aa)
mis12MIS12 kinetochore complex component. (211 aa)
spdl1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (573 aa)
ahctf1AT hook containing transcription factor 1. (2561 aa)
pold1DNA polymerase. (1107 aa)
orc2Origin recognition complex, subunit 2. (591 aa)
spo11SPO11 initiator of meiotic double stranded breaks. (399 aa)
terf2HTH myb-type domain-containing protein. (627 aa)
clasp2Cytoplasmic linker associated protein 2. (1453 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (516 aa)
cenpvCentromere protein V. (133 aa)
sgo1Shugoshin_C domain-containing protein. (654 aa)
nek2NIMA-related kinase 2. (442 aa)
LOC101158643NudE neurodevelopment protein 1-like 1a. (365 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (860 aa)
cenpkCentromere protein K. (266 aa)
chrac1Chromatin accessibility complex subunit 1. (119 aa)
dctn5Dynactin 5. (182 aa)
ska3Spindle and kinetochore associated complex subunit 3. (591 aa)
NDE1NudE neurodevelopment protein 1. (342 aa)
LOC101165590Translocated promoter region a, nuclear basket protein. (1919 aa)
LOC101163867Si:dkey-119f1.1. (1129 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1090 aa)
rangap1RAN GTPase activating protein 1a. (554 aa)
zw10Zw10 kinetochore protein. (767 aa)
ckap5Cytoskeleton associated protein 5. (1640 aa)
LOC101173147RAD21 cohesin complex component like 1. (539 aa)
sirt6Sirtuin 6. (347 aa)
LOC101155601CCAAT enhancer binding protein beta. (286 aa)
rad51dRAD51 paralog D. (332 aa)
znf276Zinc finger protein 276. (616 aa)
LOC101160375Uncharacterized protein. (544 aa)
ppp1ccSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
ercc1Excision repair cross-complementation group 1. (341 aa)
xrcc5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (725 aa)
nup37Nucleoporin 37. (323 aa)
CBX1Uncharacterized protein. (182 aa)
spc25SPC25 component of NDC80 kinetochore complex. (237 aa)
nup43Nucleoporin 43. (372 aa)
H2MU36_ORYLAUncharacterized protein. (312 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (396 aa)
trappc12Trafficking protein particle complex 12. (820 aa)
LOC110014793Histone domain-containing protein. (149 aa)
LOC111946820Structural maintenance of chromosomes 6. (1041 aa)
cfdp1Craniofacial development protein 1; May play a role during embryogenesis. (308 aa)
ska1Spindle and kinetochore associated complex subunit 1. (249 aa)
LOC101161711Zinc finger and BTB domain containing 48. (625 aa)
suv39h1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
H2MZX5_ORYLACentromere protein P. (310 aa)
znf330Zinc finger protein 330. (318 aa)
ttkTtk protein kinase. (994 aa)
mad2l1HORMA domain-containing protein. (206 aa)
Rif1Uncharacterized protein. (1520 aa)
LOC101172596Zinc finger protein 618. (919 aa)
nsmce4aNon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (351 aa)
majinUncharacterized protein. (209 aa)
AtmUncharacterized protein. (147 aa)
rassf4Ras association domain family member 4a. (367 aa)
LOC101172197TERF1 (TRF1)-interacting nuclear factor 2. (566 aa)
terf2ipUncharacterized protein. (682 aa)
ENSORLP00000027107Excision repair cross-complementation group 6-like. (632 aa)
LOC101169701Zinc finger protein 207. (429 aa)
ENSORLP00000027619TAN domain-containing protein. (321 aa)
incenpUncharacterized protein. (834 aa)
cenphCENP-H domain-containing protein. (232 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
nsmce2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (230 aa)
ENSORLP00000028463Rad21_Rec8_N domain-containing protein. (359 aa)
recql4RecQ helicase-like 4. (1546 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (911 aa)
znf827Zinc finger protein 827. (1498 aa)
cenpmProliferation associated nuclear element. (184 aa)
ENSORLP00000029827Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (171 aa)
Tep1Uncharacterized protein. (83 aa)
dhx36DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1050 aa)
terb2Telomere repeat binding bouquet formation protein 2. (212 aa)
LOC100049459Chromobox homolog 3a (HP1 gamma homolog, Drosophila). (174 aa)
cbx5Chromobox homolog 5 (HP1 alpha homolog, Drosophila). (203 aa)
LOC101162870Dynactin 1a. (1440 aa)
LOC101168459Baculoviral IAP repeat containing 5b. (147 aa)
hat1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (408 aa)
smc3Structural maintenance of chromosomes protein. (1216 aa)
ENSORLP00000032040Uncharacterized protein. (229 aa)
LOC101158122Poly [ADP-ribose] polymerase. (1283 aa)
bod1l1Uncharacterized protein. (1105 aa)
bub1BUB1 mitotic checkpoint serine/threonine kinase. (1115 aa)
nup133Nucleoporin 133. (1138 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1583 aa)
nsl1NSL1 component of MIS12 kinetochore complex. (261 aa)
spc24SPC24 component of NDC80 kinetochore complex. (199 aa)
ENSORLP00000033799Uncharacterized protein. (799 aa)
LOC101167464Death-domain associated protein. (729 aa)
dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1496 aa)
cdt1Chromatin licensing and DNA replication factor 1. (607 aa)
cenpwUncharacterized protein. (75 aa)
terf1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (454 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (359 aa)
terb1Telomere repeat binding bouquet formation protein 1. (704 aa)
ENSORLP00000035938Uncharacterized protein. (521 aa)
CBX1-2Chromobox homolog 1b (HP1 beta homolog Drosophila). (264 aa)
wrap53WD repeat containing, antisense to TP53. (467 aa)
bub1bBUB1 N-terminal domain-containing protein. (564 aa)
cenpfCentromere protein F. (2835 aa)
dmc1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
LOC101162552Lysine (K)-specific demethylase 4A, genome duplicate b. (1127 aa)
LOC101166919Dynactin 1b. (1259 aa)
rec8REC8 meiotic recombination protein b. (566 aa)
rad50RAD50 homolog, double strand break repair protein. (1311 aa)
cenpxUncharacterized protein. (107 aa)
pinx1PIN2 (TERF1) interacting telomerase inhibitor 1. (352 aa)
cep131Centrosomal protein 131. (1216 aa)
rcc2Regulator of chromosome condensation 2. (512 aa)
LOC101165555SET domain-containing protein. (1938 aa)
smc4Structural maintenance of chromosomes protein. (1296 aa)
brca2BRCA2 DNA repair associated. (3161 aa)
LOC101170539Exportin 1 (CRM1 homolog, yeast) b. (1084 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (627 aa)
zwilchZwilch kinetochore protein. (607 aa)
LOC101164346Uncharacterized protein. (231 aa)
ENSORLP00000040907TROVE domain-containing protein. (289 aa)
LOC101173508Marker of proliferation Ki-67. (1982 aa)
LOC105353570Poly [ADP-ribose] polymerase. (1266 aa)
LOC101172442C2H2-type domain-containing protein. (683 aa)
slx4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1590 aa)
phf6PHD finger protein 6. (363 aa)
LOC101164183Dynactin 3 (p22). (242 aa)
Ncapd2Uncharacterized protein. (90 aa)
gpatch11G patch domain containing 11. (258 aa)
Knl1Uncharacterized protein. (1367 aa)
fbxo28F-box protein 28. (367 aa)
LOC101175080DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1430 aa)
mad1l1Mitotic arrest deficient 1 like 1. (722 aa)
lrwd1Leucine-rich repeats and WD repeat domain containing 1. (742 aa)
nsmce1NSE1 homolog, SMC5-SMC6 complex component. (247 aa)
meaf6MYST/Esa1-associated factor 6. (263 aa)
ska2SKA2 domain-containing protein. (146 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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