(50 nodes) Negative regulation of response to DNA damage stimulus network (Oryzias latipes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	triap1	TP53 regulated inhibitor of apoptosis 1. (74 aa)
	shld2	Si:ch211-134m17.9. (721 aa)
	ercc4	Excision repair cross-complementation group 4. (889 aa)
	cdkn2d	Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
	OTUB2	OTU deubiquitinase, ubiquitin aldehyde binding 2. (236 aa)
	rmi2	RecQ mediated genome instability 2. (140 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1365 aa)
	radx	RPA1 related single stranded DNA binding protein. (815 aa)
	LOC101166554	ATPase family AAA domain containing 5a. (1758 aa)
	ogg1	8-oxoguanine DNA glycosylase. (395 aa)
	otub1	Ubiquitin thioesterase. (266 aa)
	H2M6M6_ORYLA	Structural maintenance of chromosomes flexible hinge domain containing 1. (1384 aa)
	trip12	Thyroid hormone receptor interactor 12. (2058 aa)
	recql5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (989 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (860 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (680 aa)
	yju2	YJU2 splicing factor homolog. (331 aa)
	tpt1	Translationally-controlled tumor protein; Belongs to the TCTP family. (168 aa)
	ercc1	Excision repair cross-complementation group 1. (341 aa)
	LOC110015669	Uncharacterized protein. (183 aa)
	snai2	Snail family zinc finger 2. (260 aa)
	thoc1	THO complex 1. (654 aa)
	LOC101161210	Clusterin; Belongs to the clusterin family. (452 aa)
	ackr3	Chemokine (C-X-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. (381 aa)
	LOC101166168	Clusterin; Belongs to the clusterin family. (459 aa)
	Rif1	Uncharacterized protein. (1520 aa)
	ENSORLP00000027006	Uncharacterized protein. (296 aa)
	clul1	CLb domain-containing protein. (416 aa)
	parpbp	PARP1 binding protein. (583 aa)
	LOC110013471	Uncharacterized protein. (816 aa)
	marchf7	Membrane-associated ring finger (C3HC4) 7. (807 aa)
	tmem161a	Transmembrane protein 161A. (522 aa)
	fbxo5	F-box protein 5. (367 aa)
	LOC101170047	Uncharacterized protein. (184 aa)
	LOC101175166	Si:ch73-248e21.1. (347 aa)
	fancb	FA complementation group B. (850 aa)
	chek2	Checkpoint kinase 2. (526 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1583 aa)
	psmd10	Proteasome 26S subunit, non-ATPase 10. (226 aa)
	ppp1r10	Protein phosphatase 1, regulatory subunit 10. (815 aa)
	LOC101171955	Uncharacterized protein. (225 aa)
	RNF169	Ring finger protein 169. (608 aa)
	LOC101172133	ATPase family AAA domain containing 5b. (959 aa)
	LOC101155422	Uncharacterized protein. (115 aa)
	ddias	Rep_fac-A_C domain-containing protein. (681 aa)
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (627 aa)
	fbh1	F-box DNA helicase 1. (1070 aa)
	ubr5	Ubiquitin protein ligase E3 component n-recognin 5. (2859 aa)
	trim32	Tripartite motif containing 32. (622 aa)
	ercc6	Excision repair cross-complementation group 6. (1342 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101166554	chek2	ENSORLP00000012809	ENSORLP00000032936	ATPase family AAA domain containing 5a.	Checkpoint kinase 2.	0.524
LOC101166554	ercc4	ENSORLP00000012809	ENSORLP00000003684	ATPase family AAA domain containing 5a.	Excision repair cross-complementation group 4.	0.630
LOC101166554	fbh1	ENSORLP00000012809	ENSORLP00000040243	ATPase family AAA domain containing 5a.	F-box DNA helicase 1.	0.638
LOC101166554	recql5	ENSORLP00000012809	ENSORLP00000015387	ATPase family AAA domain containing 5a.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.673
LOC101166554	rmi2	ENSORLP00000012809	ENSORLP00000006136	ATPase family AAA domain containing 5a.	RecQ mediated genome instability 2.	0.485
LOC101166554	xrcc1	ENSORLP00000012809	ENSORLP00000039866	ATPase family AAA domain containing 5a.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.525
LOC101172133	chek2	ENSORLP00000038541	ENSORLP00000032936	ATPase family AAA domain containing 5b.	Checkpoint kinase 2.	0.524
LOC101172133	ercc4	ENSORLP00000038541	ENSORLP00000003684	ATPase family AAA domain containing 5b.	Excision repair cross-complementation group 4.	0.630
LOC101172133	fbh1	ENSORLP00000038541	ENSORLP00000040243	ATPase family AAA domain containing 5b.	F-box DNA helicase 1.	0.638
LOC101172133	recql5	ENSORLP00000038541	ENSORLP00000015387	ATPase family AAA domain containing 5b.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.673
LOC101172133	rmi2	ENSORLP00000038541	ENSORLP00000006136	ATPase family AAA domain containing 5b.	RecQ mediated genome instability 2.	0.485
LOC101172133	xrcc1	ENSORLP00000038541	ENSORLP00000039866	ATPase family AAA domain containing 5b.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.525
LOC110015669	shld2	ENSORLP00000021792	ENSORLP00000003682	Uncharacterized protein.	Si:ch211-134m17.9.	0.941
LOC110015669	tp53bp1	ENSORLP00000021792	ENSORLP00000033455	Uncharacterized protein.	Tumor protein p53 binding protein, 1.	0.400
OTUB2	trip12	ENSORLP00000005741	ENSORLP00000014712	OTU deubiquitinase, ubiquitin aldehyde binding 2.	Thyroid hormone receptor interactor 12.	0.559
RNF169	Rif1	ENSORLP00000037629	ENSORLP00000025841	Ring finger protein 169.	Uncharacterized protein.	0.437
RNF169	chek2	ENSORLP00000037629	ENSORLP00000032936	Ring finger protein 169.	Checkpoint kinase 2.	0.683
RNF169	tp53bp1	ENSORLP00000037629	ENSORLP00000033455	Ring finger protein 169.	Tumor protein p53 binding protein, 1.	0.915
RNF169	trip12	ENSORLP00000037629	ENSORLP00000014712	Ring finger protein 169.	Thyroid hormone receptor interactor 12.	0.464
Rif1	RNF169	ENSORLP00000025841	ENSORLP00000037629	Uncharacterized protein.	Ring finger protein 169.	0.437